NK Cell Lectin-Like Receptor Subfamily K

An activating NK cell lectin-like receptor subfamily that regulates immune responses to INFECTION and NEOPLASMS. Members of this subfamily generally occur as homodimers.

Also Known As:

CD314 Antigen; Killer Cell Lectin-Like Receptor Subfamily K; Killer Cell Lectin-Like Receptor Subfamily K, Member 1; NK Cell Lectin-Like Receptor Subfamily K, Member 1; NK Cell Receptor D; NKG2-D Receptor; NKG2D Receptor; Antigen, CD314; Killer Cell Lectin Like Receptor Subfamily K; Killer Cell Lectin Like Receptor Subfamily K, Member 1; NK Cell Lectin Like Receptor Subfamily K; NK Cell Lectin Like Receptor Subfamily K, Member 1; NKG2 D Receptor; Receptor, NKG2-D; Receptor, NKG2D

Networked: 273 relevant articles (3 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Natural Killer Cell Receptors: 407
        NK Cell Lectin-Like Receptors
        NK Cell Lectin-Like Receptor Subfamily K: 273
        rat NKR-P2 protein: 4
        human KLRK1 protein
        mouse Klrk1 protein

Experts

1.	Sentman, Charles L: 10 articles (11/2015 - 05/2007)
2.	Lanier, Lewis L: 8 articles (01/2021 - 08/2005)
3.	Zhang, Tong: 7 articles (11/2014 - 05/2007)
4.	Spies, Thomas: 7 articles (01/2014 - 04/2003)
5.	Valés-Gómez, Mar: 6 articles (05/2018 - 03/2008)
6.	Raulet, David H: 6 articles (12/2017 - 02/2003)
7.	Barber, Amorette: 6 articles (02/2015 - 05/2007)
8.	Groh, Veronika: 6 articles (01/2014 - 08/2005)
9.	Chitadze, Guranda: 5 articles (01/2022 - 04/2016)
10.	Kabelitz, Dieter: 5 articles (01/2022 - 04/2016)

Related Diseases

1.	Neoplasms (Cancer) 06/21/2019 - "The immunomodulatory effects are consistent with a putative improvement in cancer immunosurveillance via the upregulation of the NKG2D receptor. " 01/01/2008 - "In this study, we show that treatment with T cells expressing a chimeric NKG2D receptor (chNKG2D) was able to lead to long-term, tumor-free survival in mice bearing established ovarian tumors. " 01/01/2022 - "γδT cells recognize stressed cells or cancer cells through the NKG2D receptor to kill these cells and maintain normality. " 01/01/2022 - "However, NKG2D receptor did not significantly change among tumors. " 10/01/2021 - "The natural killer (NK) group 2D (NKG2D) receptor plays a crucial role in NK cell-mediated anti-tumor immunity. "
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2017 - "Prognostic significance and functional implication of immune activating receptor NKG2D in gastric cancer." 12/01/2020 - "A novel bispecific chimeric PD1-DAP10/NKG2D receptor augments NK92-cell therapy efficacy for human gastric cancer SGC-7901 cell." 01/01/2017 - "Our data showed that NKG2D receptor could be an independent favorable prognostic indicator for gastric cancer. "
3.	Infections 03/01/2008 - "The present study was undertaken to reveal the functional contributions of the activating NKG2D receptor in host defense and disease following JHMV infection. " 05/01/2009 - "Furthermore, NK cells from patients with active HSV-1 infection had a tendency towards increased expression level of the activating receptor NKG2D. " 01/01/2016 - "The immune receptor NKG2D is present in all human Natural Killer and T cells and plays an important role in the first barrier of defense against tumor and infection. " 01/01/2013 - "The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting the host from infections and cancer. " 09/01/2015 - "This study showed that HCV infection might abrogate NK cytotoxic potential through altering PU.1, NKG2D receptor and perforin molecules."
4.	Lymphoma (Lymphomas) 09/01/2015 - "Here, we study the role of the NK group 2D (NKG2D) receptor for the immunosurveillance of lymphoma. " 09/01/2015 - "This indicates that NK cells and the NKG2D receptor play a role for control of lymphomas and that selection for NKG2D-L loss mutants provides a mechanism of tumor escape. " 11/15/2007 - "In this study, the efficacy and mechanisms of chimeric NKG2D receptor (chNKG2D)-modified T cells in eliminating NKG2D ligand-positive RMA/Rae1 lymphoma cells were evaluated. " 01/01/2014 - "Stress-related immunity can be triggered both in Hodgkin's (HL) and non-Hodgkin lymphomas (NHL), through the activation of the NKG2D receptor on CD8+ T and gammadelta T lymphocytes, by NKG2D-ligands (NKG2D-L), as the MHC class-I related molecules MIC-A/B and the UL16-binding proteins 1-4 (ULBPs), expressed on lymphoma cells. " 02/25/2011 - "In this report we have used Jurkat and Raji cell lines as a model for studies of the NKG2D receptor-ligand system in T-and B cell leukemia/lymphoma. "
5.	Melanoma (Melanoma, Malignant) 07/05/2023 - "Our findings revealed that co-culture with melanoma cell lines led to a significant impairment in the expression of the NKG2D receptor and cytolytic granules in iNKT cells. " 12/01/2011 - "Furthermore, these melanoma patients have a significant decrease in the expression of activating NKG2D receptor, which positively correlates with NK cytotoxicity, and a significant increase in the expression of inhibitory CD158b on CD3-CD56+ NK cells compared with healthy controls. " 01/01/2011 - "While the NKG2D receptor has been described as the principal entity responsible for the lysis of several melanoma cell lines, the role of natural cytotoxicity receptors (NCRs) and DNAM-1 receptors in NK cell recognition and killing of melanoma cells has been recently emphasized. " 07/01/2008 - "This study analyzes the effects of acute social stress and different coping strategies employed in response to it on the development of B16F10 melanoma pulmonary metastases, the activation of the HPA axis and the NKG2D receptor expression. " 05/01/2015 - "The favorable effects of CEACAM1-3S related to enhanced immunogenicity, which was mediated by cell surface upregulation of NKG2D receptor ligands, thereby sensitizing melanoma cells to lysis by natural killer cells. "

Related Drugs and Biologics

1.	Ligands
2.	interleukin-21 (interleukin 21)
3.	mica
4.	Proteins (Proteins, Gene)
5.	Carrier Proteins (Binding Protein)
6.	Perforin
7.	Transforming Growth Factor beta1 (TGF beta 1)
8.	Annexin A5
9.	Cytokines
10.	Antigens

Related Therapies and Procedures

1.	Therapeutics
2.	Cell Transplantation
3.	Immunotherapy
4.	Transplantation
5.	Immunomodulation