Multiple Pulmonary Nodules

A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.

Also Known As:

Networked: 58 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Small Cell Carcinoma
2.	Neoplasm Metastasis (Metastasis)
3.	Rheumatoid Arthritis
4.	Wegener Granulomatosis (Wegener's Granulomatosis)
5.	Neoplasms (Cancer)

Experts

1.	Silva, Luigi Ferreira e: 1 article (05/2015)
2.	Dias, George Alberto da Silva: 1 article (05/2015)
3.	Cruz, Lorena de Britto Pereira: 1 article (05/2015)
4.	Koyama, Roberta Vilela Lopes: 1 article (05/2015)
5.	Yoshikawa, Gilberto Toshikawa: 1 article (05/2015)
6.	Fuzii, Hellen Thais: 1 article (05/2015)
7.	Fujihara, Satomi: 1 article (05/2015)
8.	Matsumoto, Takuya: 1 article (01/2015)
9.	Onishi, Sachiko: 1 article (01/2015)
10.	El-Deiry, Wafik S: 1 article (01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Pulmonary Nodules:

1.	DNA (Deoxyribonucleic Acid)IBA 02/01/2011 - "In this study, we measured CTCs and plasma DNA in a published group of patients with multiple pulmonary nodules and indeterminate metastatic disease. "
2.	NocardiosisIBA 01/01/2015 - "Pulmonary nocardiosis presents mainly as multiple pulmonary nodules, consolidations, and cavity in both immunocompromised and immunocompetent patients. " 12/01/2001 - "[Pulmonary nocardiosis as a cause of radiographic imaging of multiple pulmonary nodules]." 01/01/1995 - "In the immunocompromised and chronically debilitated host, pulmonary nocardiosis should be included in differential diagnosis if chest CT shows consolidation with low attenuation areas with or without cavitation, multiple pulmonary nodules, pleural effusion, and chest wall extension." 06/01/2009 - "[A case of primary pulmonary nocardiosis with multiple pulmonary nodules successfully treated with moxifloxacin]."
3.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 07/01/2007 - "ANCA-negative Wegener's granulomatosis should be considered when we diagnose multiple pulmonary nodules." 01/01/2012 - "SBE may present with positive c-ANCA/PR3, multiple pulmonary nodules, pulmonary polyangiitis, and glomerulonephritis clinically mimicking granulomatosis with polyangiitis (Wegener's granulomatosis)." 02/01/2009 - "The case of MPO-ANCA positive vasculitis associated with multiple pulmonary nodules following propylthiouracil treatment is very rare." 02/01/2009 - "[A case of MPO-ANCA positive vasculitis associated with multiple pulmonary nodules following propylthiouracil treatment]."
4.	Methotrexate (Mexate)FDA LinkGeneric 01/01/2015 - "Methotrexate-associated Lymphoproliferative Disease with Multiple Pulmonary Nodules in a Patient with Rheumatoid Arthritis." 01/01/2010 - "We report the case of a 60-year-old male with rheumatoid arthritis previously treated with methotrexate and cyclosporin, in whom multiple pulmonary nodules were disclosed. " 03/01/1978 - "A patient who had undergone amputation and adjuvant chemotherapy with methotrexate doxorubicin hydrochloride for osteosarcoma of the femur later developed granulomatous hilar and paratracheal lymphadenopathy and multiple pulmonary nodules. "
5.	Doxorubicin (Adriamycin)FDA LinkGeneric 03/01/1978 - "A patient who had undergone amputation and adjuvant chemotherapy with methotrexate doxorubicin hydrochloride for osteosarcoma of the femur later developed granulomatous hilar and paratracheal lymphadenopathy and multiple pulmonary nodules. " 10/01/2010 - "The following regimen of chemotherapy was given: each course consisted of ifosfamide (1,000 mg/m²) on days 1-5, adriamycin (60 mg/m²) on day 1, and cisplatin (15 mg/m²) on days 1-5. After 4 courses of the chemotherapy, the intraabdominal mass and multiple pulmonary nodules were reduced 45. " 02/01/1997 - "Her WHO performance status was grade 4. After chemotherapy consisting of ifosfamide, Adriamycin, and cisplatin, the uterus shrank from 20 x 15 x 15 to 6 x 6 x 8 cm and multiple pulmonary nodules almost completely disappeared. "
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/1989 - "One patient developed multiple pulmonary nodules due to cyclosporine-induced lymphoma." 01/01/2010 - "We report the case of a 60-year-old male with rheumatoid arthritis previously treated with methotrexate and cyclosporin, in whom multiple pulmonary nodules were disclosed. "
7.	IfosfamideFDA LinkGeneric 10/01/2010 - "The following regimen of chemotherapy was given: each course consisted of ifosfamide (1,000 mg/m²) on days 1-5, adriamycin (60 mg/m²) on day 1, and cisplatin (15 mg/m²) on days 1-5. After 4 courses of the chemotherapy, the intraabdominal mass and multiple pulmonary nodules were reduced 45. " 02/01/1997 - "Her WHO performance status was grade 4. After chemotherapy consisting of ifosfamide, Adriamycin, and cisplatin, the uterus shrank from 20 x 15 x 15 to 6 x 6 x 8 cm and multiple pulmonary nodules almost completely disappeared. "
8.	Cisplatin (Platino)FDA LinkGeneric 10/01/2010 - "The following regimen of chemotherapy was given: each course consisted of ifosfamide (1,000 mg/m²) on days 1-5, adriamycin (60 mg/m²) on day 1, and cisplatin (15 mg/m²) on days 1-5. After 4 courses of the chemotherapy, the intraabdominal mass and multiple pulmonary nodules were reduced 45. " 02/01/1997 - "Her WHO performance status was grade 4. After chemotherapy consisting of ifosfamide, Adriamycin, and cisplatin, the uterus shrank from 20 x 15 x 15 to 6 x 6 x 8 cm and multiple pulmonary nodules almost completely disappeared. "
9.	Amyloid (Amyloid Fibrils)IBA 06/01/2012 - "Nodular parenchymal amyloid, an unusual cause of multiple pulmonary nodules with favourable long term prognosis." 01/01/1994 - "Sjögren's syndrome with amyloid A presenting as multiple pulmonary nodules."
10.	Mesalamine (Mesalazine)FDA LinkGeneric 05/01/2003 - "We report a patient with inactive CD treated with mesalazine, who presented with multiple pulmonary nodules. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1997 - "We describe a single case of small cell carcinoma of the lung presenting as multiple pulmonary nodules that seems to have been cured by chemotherapy." 02/01/2004 - "Patient 1 (aged 62 years) had multiple pulmonary nodules and underwent 2 separate lung biopsies, the first showing nodules composed of kappa light-chain deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to the lung and the second, obtained after chemotherapy 9 months later, showing only residual nodules without persistent lymphoma. " 06/01/1979 - "Clinically he had a mediastinal mass and bilateral multiple pulmonary nodules which showed a rapid growth despite cancer chemotherapy. " 03/01/2004 - "Approximately one year later, she was hospitalized because of metastatic disease with multiple pulmonary nodules, and a chemotherapy regimen consisting of paclitaxel and carboplatin was administered. " 10/01/2010 - "The following regimen of chemotherapy was given: each course consisted of ifosfamide (1,000 mg/m²) on days 1-5, adriamycin (60 mg/m²) on day 1, and cisplatin (15 mg/m²) on days 1-5. After 4 courses of the chemotherapy, the intraabdominal mass and multiple pulmonary nodules were reduced 45. "
2.	Hysterectomy 07/01/2014 - "Benign metastasizing leiomyoma (BML) was initially used to describe single or multiple pulmonary nodules composed of proliferating smooth muscle cells (lacking cellular atypia) in premenopausal females 3 months to 20 y after hysterectomy for uterine leiomyoma. " 09/01/2011 - "A 48-year-old woman was admitted to our hospital because of multiple pulmonary nodules on the chest radiograph 7 years after total hysterectomy with removal of the left ovarium for uterine leiomyoma. " 06/01/2008 - "We describe the clinical and pathologic findings in a 49-year-old woman who had undergone hysterectomy 15 years before presentation was referred to evaluate for pulmonary metastases with typical radiologic findings of bilateral multiple pulmonary nodules. " 05/01/2001 - "A 53-year-old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. " 09/01/1976 - "A 42-year-old woman was found to have multiple pulmonary nodules 7 years after hysterectomy for leiomyoma. "
3.	Transplantation (Transplant Recipients) 12/01/2004 - "Both patients presented with multiple pulmonary nodules in the transplanted lung, which developed 6 months and 2 years after the transplantation, respectively. " 09/21/2000 - "A 69-year-old renal transplant recipient with low grade fever and multiple pulmonary nodules." 10/01/2003 - "Most patients with IPA presented with fever and cough within the first 90 days of transplantation and with single or multiple pulmonary nodules. "
4.	Adjuvant Chemotherapy 01/01/2015 - "Multivariable analysis revealed that age, multiple pulmonary nodules, thoracic lymph node metastasis, and adjuvant chemotherapy are independent predictors of survival. " 03/01/1978 - "A patient who had undergone amputation and adjuvant chemotherapy with methotrexate doxorubicin hydrochloride for osteosarcoma of the femur later developed granulomatous hilar and paratracheal lymphadenopathy and multiple pulmonary nodules. "
5.	X-Ray Film 03/28/1998 - "The most frequent finding both on X-ray film of the chest and pulmonary computed tomography were bilateral multiple pulmonary nodules. " 05/01/1996 - "Second patient was a 55-years-old female with rheumatoid arthritis and a chest X-ray film showed multiple pulmonary nodules, which were thought to be metastatic lung tumor from unknown origin. "