Natural Killer Cell Receptors

Receptors that are specifically found on the surface of NATURAL KILLER CELLS. They play an important role in regulating the cellular component of INNATE IMMUNITY.

Also Known As:

Receptors, Natural Killer Cell; NK Cell Receptors; Natural Killer Cell Activating Receptors; Natural Killer Cell Inhibitory Receptors; Cell Receptor, NK; Cell Receptors, NK; Receptor, NK Cell; Receptors, NK Cell; NK Cell Receptor; Natural Killer Cell Activating Receptor; Natural Killer Cell Inhibitory Receptor; Natural Killer Cell Receptor

Networked: 407 relevant articles (11 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Natural Killer Cell Receptors: 407
        KIR Receptors: 632
        Natural Cytotoxicity Triggering Receptors: 1
        human KLRF1 protein
        NK Cell Lectin-Like Receptors

Experts

1.	Moretta, Lorenzo: 9 articles (12/2015 - 08/2004)
2.	Altfeld, Marcus: 7 articles (01/2021 - 09/2006)
3.	Tian, Zhigang: 7 articles (01/2021 - 03/2004)
4.	Mavilio, Domenico: 7 articles (01/2019 - 08/2007)
5.	López-Botet, Miguel: 7 articles (01/2017 - 12/2004)
6.	De Maria, Andrea: 7 articles (03/2015 - 05/2005)
7.	Moretta, Alessandro: 7 articles (01/2014 - 05/2005)
8.	Sentman, Charles L: 6 articles (01/2022 - 01/2006)
9.	Mandelboim, Ofer: 6 articles (01/2017 - 05/2006)
10.	Carrington, Mary: 5 articles (01/2022 - 08/2004)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2005 - "In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. " 01/01/2023 - "In this study, we established decision rules for NK-cell receptor restriction from the largest published cohorts of healthy donors and NK-cell neoplasms. " 01/01/2023 - "Establishing NK-cell receptor restriction by flow cytometric immunophenotyping is an important step in diagnosing NK-cell neoplasms, but reference interval (RI) data for interpreting these studies are lacking. " 04/01/2015 - "In this study, the tumor recognition ability of a natural killer cell-activating receptor, DNAM-1 was harnessed to design CARs that target multiple tumor types. " 01/01/2008 - "Manipulating the balance between inhibitory and activating NK receptor signals, sensitization of tumor target cells to NK cell-mediated apoptosis, and recent discoveries in NK-cell receptor biology have fueled translational research that has led to clinical trials investigating a number of novel methods to potentiate NK cytotoxicity against human malignancies."
2.	Infections 12/01/2008 - "As unconventional T-lymphocytes expressing natural killer cell receptors are considered to play central roles in the immune response against infection, a study investigating their frequencies in normal and H. " 01/01/2022 - "Compared to 60 HIV-1- controls, HIV-1 infection was associated with significant changes within the NK cell receptor repertoire, including reduced percentages of NK cells expressing NKG2A, CD8, and KIR2DS4. " 01/01/2022 - "In human immunodeficiency virus type 1 (HIV-1) infection, increased immune control has been associated with the expression of certain natural killer (NK) cell receptors. " 12/12/2019 - "NK cells are among the first immune cells that respond to CMV infection and use germ line-encoded NK cell receptors (NKR) to distinguish healthy from virus-infected cells. " 11/13/2017 - "Nevertheless, the presence of specific haplotypes for NK cell receptors and the engagement of NK cell antibody-dependent cell cytotocity have been reported to control HIV-1 infection. "
3.	Virus Diseases (Viral Diseases) 01/01/2020 - "Control of Viral Infection by Natural Killer Cell Inhibitory Receptors." 01/01/2020 - "The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection." 01/01/2019 - "Conserved and variable natural killer cell receptors: diverse approaches to viral infections." 01/01/2014 - "Baseline and Dynamic Expression of Activating NK Cell Receptors in the Control of Chronic Viral Infections: The Paradigm of HIV-1 and HCV." 04/01/2011 - "NK cell receptor/H2-Dk-dependent host resistance to viral infection is quantitatively modulated by H2q inhibitory signals."
4.	Breast Neoplasms (Breast Cancer) 11/26/2020 - "This study aims to analyze NK cells and NK cell receptor expression of obese mice in a model for postmenopausal breast cancer. " 11/26/2020 - "The present study gives novel insights into gene expression of NK cell receptors in obesity and aims to promote possible links of the obesity-impaired NK cell physiology and the elevated breast cancer risk in obese women." 01/01/2021 - "Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab." 12/01/2017 - "Analysis of TCGA datasets revealed an association between high expression of BATF3 and IRF8 and improved survival of breast cancer patients; BATF3 expression also significantly correlated with NK-cell receptor genes, IL12, and IFNG Collectively, our findings show that IL12 from CD103+ DCs is critical for NK cell-mediated control of tumor metastasis. " 01/01/2021 - "Here, we found that the nonclassical histocompatibility antigen HLA-G desensitizes breast cancer cells to trastuzumab by binding to the natural killer (NK) cell receptor KIR2DL4. "
5.	Autoimmune Diseases (Autoimmune Disease) 07/24/2013 - "Interplay between a natural killer (NK)-cell receptor, NKp30, and other cells in the salivary glands profoundly affects pathogenesis of the autoimmune disease Sjögren's syndrome (Rusakiewicz et al., this issue). " 12/01/2010 - "Taken together with our expanding knowledge of the genetical variability of NK cell receptors and NK cell physiology, these findings pave the way for the dissection of the role of NK cells in human autoimmune diseases. " 12/15/2008 - "Because it is suggested that T-cells expressing natural killer cell receptors (NKR) play important roles in regulating human autoimmune diseases, we have quantified populations of T-cells expressing the NKR CD56, CD161 and CD94 in the peripheral blood of MS patients, in healthy control subjects (HS) and in patients with other neurological diseases (OND). " 03/01/2004 - "The role of NK cells and NK cell receptors in autoimmune disease." 01/01/2019 - "We hypothesized that the interactions between NK cell receptors and targeted cells construct an eventual niche, and this niche has an eventual profile in various autoimmune diseases and cancers. "

Related Drugs and Biologics

1.	Cytokines
2.	Ligands
3.	Interleukin-15 (Interleukin 15)
4.	Chimeric Antigen Receptors
5.	Interleukin-2 (IL2)
6.	KIR Receptors
7.	Monoclonal Antibodies
8.	Antibodies
9.	Interleukin-12 (IL 12)
10.	Surface Antigens (Surface Antigen)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Transplantation
5.	Ligation