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Neutral Ceramidase

A ceramidase subtype that is active at neutral pH. It is found at high levels within the SMALL INTESTINE and in the BRAIN.

Networked: 23 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Amidohydrolases: 43
      - Ceramidases: 112
        Neutral Ceramidase: 23
        human ASAH2 protein
        mouse Asah2 protein
        rat Asah2 protein
        zebrafish neutral ceramidase

Experts

1.	Hannun, Yusuf A: 9 articles (01/2022 - 12/2012)
2.	Coant, Nicolas: 7 articles (01/2022 - 12/2016)
3.	Obeid, Lina M: 4 articles (01/2022 - 12/2012)
4.	Doll, Mark A: 3 articles (01/2022 - 01/2021)
5.	Snider, Ashley J: 3 articles (01/2022 - 12/2012)
6.	Airola, Michael V: 2 articles (01/2022 - 01/2021)
7.	Chen, Liang: 2 articles (01/2022 - 01/2021)
8.	Choi, Yong-Mi: 2 articles (01/2022 - 01/2021)
9.	Chu, Shenghui: 2 articles (01/2022 - 01/2021)
10.	Deng, Zhongbin: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer." 01/01/2021 - "In this study, we report that neutral ceramidase (N-acylsphingosine amidohydrolase [ASAH2]) is highly expressed in tumor-infiltrating MDSCs in colon carcinoma and acts as an MDSC survival factor. "
2.	Hypertension (High Blood Pressure) 03/07/2022 - "The objective of this study was to investigate the effect of empagliflozin on the levels of sphingomyelin and its metabolites, as well as on the activity of acid and neutral sphingomyelinase (aSMase and nSMase) and neutral ceramidase (nCDase) in the plasma, kidney, heart, and liver of streptozotocin-induced diabetic and Angiotensin II (Ang II)-induced hypertension rats. "
3.	Carcinoma (Carcinomatosis) 01/01/2021 - "In this study, we report that neutral ceramidase (N-acylsphingosine amidohydrolase [ASAH2]) is highly expressed in tumor-infiltrating MDSCs in colon carcinoma and acts as an MDSC survival factor. "
4.	Infections 01/01/2022 - "Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection." 01/01/2022 - "Lowering the amount of ceramide or ceramide blockade due to inhibitors of ASM, genetic downregulation of ASM, anti-ceramide antibodies or degradation by neutral ceramidase protected against infection with SARS-CoV-2. " 12/01/2016 - "Restoration of sphingosine levels through direct sphingosine administration or conversion of the increased ceramide to sphingosine by neutral ceramidase reduces mortality and mitigates pulmonary infection after burn injury."
5.	Colonic Neoplasms (Colon Cancer) 01/01/2018 - "AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells." 12/01/2016 - "Role of neutral ceramidase in colon cancer." 12/01/2016 - "Role of neutral ceramidase in colon cancer." 01/01/2021 - "There is interest in developing inhibitors of human neutral ceramidase (nCDase) because this enzyme plays a critical role in colon cancer. " 12/01/2016 - "Neutral ceramidase (nCDase), a key enzyme in sphingolipid metabolism that hydrolyzes ceramide into sphingosine, is highly expressed in the intestine; however, its role in colon cancer has not been defined. "

Related Drugs and Biologics

1.	Sphingomyelin Phosphodiesterase (Sphingomyelinase)
2.	empagliflozin
3.	Ceramidases
4.	Streptozocin (Streptozotocin)
5.	Sphingomyelins
6.	Angiotensin II
7.	Acids
8.	Ceramides
9.	Sphingosine
10.	Enzymes