Ceramidases

Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.

Also Known As:

Networked: 112 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kutlu, Hatice Mehtap: 5 articles (02/2021 - 11/2015)
2.	Casas, Josefina: 4 articles (04/2021 - 08/2011)
3.	Hannun, Yusuf A: 4 articles (01/2021 - 04/2002)
4.	Arenz, Christoph: 3 articles (10/2022 - 10/2012)
5.	Bongarzone, Ernesto R: 3 articles (01/2022 - 05/2012)
6.	van Breemen, Richard: 3 articles (01/2022 - 07/2011)
7.	Inoue, Hiroyuki: 3 articles (10/2021 - 02/2009)
8.	Kawada, Manabu: 3 articles (10/2021 - 02/2009)
9.	Bielawska, Alicja: 3 articles (09/2020 - 04/2002)
10.	Ito, Makoto: 3 articles (12/2016 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/16/2022 - "However, whether and how ceranib-2, a novel ceramidase inhibitor, can exert its cytotoxic and apoptotic effects on RAW 264.7, a macrophage cell line established from a tumor in a male mouse induced with the Abelson murine leukemia virus, remains unknown. " 11/16/2022 - "Inhibition of ceramidase is reportedly related to apoptosis and cytotoxicity in macrophages, which are closely related to tumor development and progression. " 11/16/2022 - "Many ceramidase inhibitors have been developed and identified as potential treatment agents for various types of tumors in the last several decades. " 01/01/2021 - "Ceranib-2 is a recently discovered, poorly water-soluble potent ceramidase inhibitor, with the ability to suppress cancer cell proliferation and delay tumor growth. " 12/01/2020 - "Inhibition of ceramidases as new targets for cancer treatment is shown in the literature. "
2.	Renal Cell Carcinoma (Grawitz Tumor) 10/01/2023 - "Efficacy of ceramidase inhibition on human renal cell carcinoma: a cell culture study." 10/01/2023 - "MTT colorimetric assay results for 24 hours indicated that the viability of human renal cell carcinoma cells decreased compared to the control group with an increase in the applied concentration of the ceramidase inhibitor-ceranib-2. " 10/01/2023 - "We aimed to investigate if the inhibition of ceramidases induces death in the human renal cell carcinoma cell line. " 10/01/2023 - "The results of our study indicated that the application of ceramidase inhibitor, ceranib-2 on human renal cell carcinoma A-498 cells cause cytotoxicity, antiproliferative, growth inhibitory, and apoptotic efficacies in a dose and time-dependent manner probably via inhibiting the acid ceramidases that hydrolyze ceramides that induce cell death. "
3.	Farber Lipogranulomatosis 02/01/2002 - "Point mutations in the gene (Asah1) encoding one ceramidase, acid ceramidase (AC), lead to the lysosomal storage disorder Farber disease (FD). " 10/04/2001 - "The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells." 08/30/1993 - "The time course of degradation of a radiolabelled natural ceramide has been studied in intact, living lymphoid cells and skin fibroblasts from normal individuals and from patients affected with Farber disease, an inborn disorder of ceramide metabolism due to deficient activity of lysosomal ceramidase. " 07/01/1989 - "Leukocyte and plasma N-laurylsphingosine deacylase (ceramidase) in Farber disease." 08/01/1982 - "The specific activity of acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23) was measured at pH4.5 in normal fibroblasts and in fibroblasts from patients with Farber disease and obligate heterozygotes. "
4.	Breast Neoplasms (Breast Cancer) 02/01/2021 - "Correction to: Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor." 12/01/2020 - "Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor." 01/01/2020 - "These findings establish PAQR4 as Golgi-localized ceramidase required for cellular growth in breast cancer. " 01/01/2020 - "Induction of PAQR4 in breast tumors was found to be subtype-independent and correlated with increased ceramidase activity. " 01/01/2020 - "Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer."
5.	Prostatic Neoplasms (Prostate Cancer) 11/01/2015 - "This study investigates the potential for ceranib-2, a novel ceramidase inhibitor, to affect the survival and/or promote apoptosis of prostate cancer cells (LNCaP and DU145) in vitro. " 11/01/2015 - "Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2." 08/10/2003 - "N-oleoylethanolamine (OE), an inhibitor of acidic ceramidase, consistently potentiated the apoptotic effects of PD153035 in all the prostatic cancer cell lines tested. " 06/15/2003 - "The apoptotic/necrotic responses induced by ANA on these prostatic cancer cells were also potentiated by the acidic ceramidase inhibitor, N-oleoylethanolamine and partially inhibited by the specific ceramide synthetase inhibitor, fumonisin B1 indicating that these cytotoxic actions of ANA might be induced via the cellular ceramide production. "

Related Drugs and Biologics

1.	Ceramides
2.	Ceramidases
3.	Acids
4.	dihydroceramide desaturase
5.	Sphingomyelins
6.	Serine C-Palmitoyltransferase
7.	Protein Isoforms (Isoforms)
8.	Neutral Ceramidase
9.	Sulfoglycosphingolipids (Sulfatides)
10.	Luciferases

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Therapeutics
4.	Neoadjuvant Therapy