HSP27 Heat-Shock Proteins

A subfamily of small heat-shock proteins that function as molecular chaperones that aid in refolding of non-native proteins. They play a protective role that increases cellular survival during times of stress.

Also Known As:

HSP27 Protein; HSP27 Proteins; Heat Shock Protein beta-1; Heat-Shock Protein 27; Heat-Shock Proteins 27; HSP27 Heat Shock Proteins; Heat Shock Protein 27; Heat Shock Protein beta 1; Heat Shock Proteins 27; Heat-Shock Proteins, HSP27; Protein 27, Heat-Shock

Networked: 662 relevant articles (11 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Molecular Chaperones: 1279
    - Heat-Shock Proteins: 8088
      - Small Heat-Shock Proteins: 401
        HSP27 Heat-Shock Proteins: 662
        human HSPB2 protein
        human HSPB7 protein
        human TAT-HSP27 fusion protein
        mouse Hspb2 protein
        mouse HSPB7 protein
        phenylalanyl-glutamyl-glutaminyl-phenylalanyl-leucyl-aspartyl-isoleucine
        rat Hspb1 protein
        rat Hspb2 protein
        zebrafish hspb1 protein
        zebrafish Hspb7 protein

Experts

1.	Ghayour-Mobarhan, Majid: 19 articles (11/2021 - 06/2008)
2.	O'Brien, Edward R: 16 articles (01/2021 - 03/2005)
3.	Tavallaie, Shima: 12 articles (01/2019 - 06/2008)
4.	Rocchi, Palma: 11 articles (01/2022 - 09/2004)
5.	Kuramitsu, Yasuhiro: 11 articles (11/2018 - 12/2007)
6.	Gleave, Martin: 10 articles (01/2022 - 09/2004)
7.	Ferns, Gordon A: 9 articles (11/2021 - 05/2011)
8.	Chen, Yong-Xiang: 9 articles (11/2020 - 03/2005)
9.	Shi, Chunhua: 8 articles (11/2020 - 01/2013)
10.	Moohebati, Mohsen: 8 articles (01/2019 - 06/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "The aim of this study was to determine the intensity of Hsp27 protein expression in fibrocystic breast changes (FC) and invasive ductal breast carcinoma (IDC) and to examine its impact on patients' clinico-pathological characteristics and overall survival. " 01/01/2007 - "This study utilized two breast cancer cell lines differing only in their expression of heat shock protein 27 (hsp27). " 01/01/2023 - "Here, we identified novel functional roles of heat shock protein beta-1 (HSPB1), regulating chemoresistance and ferroptotic cell death in breast cancer. " 10/01/2020 - "Using early lesion breast cancer models, we demonstrate that the effect of p38 suppression by Her2 on early dissemination is mediated by MK2 and heat shock protein 27 (Hsp27). " 12/05/2014 - "Finally, we applied this approach to determine the phosphorylation stoichiometry of heat shock protein 27 (HSP27) at Ser78 and Ser82 in breast cancer cells and tissue samples."
2.	Neoplasms (Cancer) 05/01/2013 - "In many tumors, the heat shock protein 27 (Hsp27) is expressed at high levels to provide protection against anticancer drugs. " 07/01/2014 - "Previous studies have indicated that heat shock protein 27 (HSP27) had high correlation with the development and progression in several tumors. " 09/01/2022 - "Heat shock protein 27 (HSP27) plays important roles in many cellular processes and has been implicated in different types of diseases such as cancers. " 04/07/2021 - "Interestingly, it was evidenced by a significant increase in the survival rate of C26 tumor-bearing mice accompanied by a significant increase in Hsp90 and Hsp27 protein levels in the tumors. " 12/01/2020 - "The heat shock protein 27 (HSP27) is recognized as a prominent factor in OC, playing a pivotal role in cancer progression machinery such as treatment resistance. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 07/01/2015 - "Results of our previous studies demonstrated that the expression of heat-shock protein 27 (HSP27) was increased and HSP27 was phosphorylated in the GEM-resistant pancreatic cancer cell line, KLM1-R. " 07/01/2010 - "Our previous proteomic study demonstrated that the expression of three spots of heat-shock protein 27 (HSP27) was increased in GEM-resistant pancreatic cancer cells and could play a role in determining the sensitivity of pancreatic cancer to GEM. " 03/22/2016 - "The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer." 01/21/2016 - "The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer." 05/01/2009 - "Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma."
4.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2010 - "In a preliminary proteomic study, variation in the levels of heat shock protein 27 (HSP27) in colorectal cancer samples was observed. " 08/31/2021 - "Heat Shock Proteins 27, 70, and 110: Expression and Prognostic Significance in Colorectal Cancer." 03/01/2010 - "To investigate the expression of 14-3-3 sigma and heat shock protein 27 (HSP27) in colorectal carcinoma(CRC) tissue and its clinical significance. " 03/01/2010 - "[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]." 01/01/2022 - "The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer."
5.	Necrosis 11/01/2022 - "The protective effect against apoptosis or necrosis after mild-temperature PTT and PTT + PDT was correlated with the upregulation of heat shock protein 27. " 02/01/2014 - "Further mechanistic studies suggest injury pathways associated with heat shock proteins 27 and 70 should contribute to the enhanced cancer cell destruction by inducing cell apoptosis and necrosis. " 10/01/2013 - "Interestingly, we identified the stress chaperone heat shock protein beta-1, a main protector of muscle necrosis, as a target of Oligopin® and showed that this polyphenol was able to modulate its stress induced phosphorylation." 10/01/2009 - "Since heat shock protein 27 (HSP27) protects against apoptosis, necrosis, and stabilizes F-actin, we questioned whether overexpression of human HSP27 (huHSP27 OE) in mice would attenuate AKI after liver IRI. " 11/01/2017 - "The antiviral role of heat shock protein 27 against red spotted grouper nervous necrosis virus infection in sea perch."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	apatorsen
4.	Antisense Oligonucleotides
5.	Gemcitabine
6.	Glutathione Transferase (Glutathione S-Transferase)
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Paclitaxel (Taxol)
9.	Carboplatin (JM8)
10.	Pemetrexed (MTA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Castration
3.	Therapeutics
4.	Radiotherapy
5.	Prostatectomy (Retropubic Prostatectomy)