epsilon-Globins

A member of the beta-globin family. In humans, epsilon-globin is encoded in the beta-globin gene cluster located on CHROMOSOME 11. Two epsilon-globin chains combine with two ZETA-GLOBIN chains to form the embryonic hemoglobin Gower I or two epsilon-globin chains combine with two ALPHA-2 GLOBIN chains to form the embryonic hemoglobin Gower II.

Also Known As:

Networked: 26 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	He, Zhenning: 2 articles (01/2007 - 08/2002)
2.	Russell, J Eric: 2 articles (01/2007 - 08/2002)
3.	Cho, Hee Jun: 1 article (04/2019)
4.	Kim, Bo Yeon: 1 article (04/2019)
5.	Kim, Jong-Tae: 1 article (04/2019)
6.	Lee, Hee Gu: 1 article (04/2019)
7.	Lee, Kyung Ho: 1 article (04/2019)
8.	Lee, Seon-Jin: 1 article (04/2019)
9.	Lee, Younghee: 1 article (04/2019)
10.	Park, Sang Yoon: 1 article (04/2019)

Related Diseases

1.	Sickle Cell Anemia (Hemoglobin S Disease) 08/06/2002 - "The current work analyzes the antisickling properties of an epsilon -globin-containing heterotetramer (Hb Gower-2) both in vitro as well as in vivo in a well-established mouse model of sickle cell anemia. " 01/15/2007 - "Functional studies of embryonic epsilon-globin indicate that individuals with beta thalassemia or sickle cell disease are likely to benefit from therapeutic, transcriptional derepression of its encoding gene. "
2.	beta-Thalassemia (Cooley's Anemia) 01/15/2007 - "Functional studies of embryonic epsilon-globin indicate that individuals with beta thalassemia or sickle cell disease are likely to benefit from therapeutic, transcriptional derepression of its encoding gene. " 01/15/2007 - "Importantly, the constitutive stability of epsilon-globin mRNA increases in transgenic mouse models of beta thalassemia, suggesting that epsilon- and beta-globin mRNAs are coregulated through a shared posttranscriptional mechanism. "
3.	Neoplastic Processes 04/01/1988 - "This immunoassay is useful for the study of epsilon globin ontogeny during embryonic and fetal development as well as for searching for inappropriate epsilon globin chain expression in hematologic disorders resulting from genetic abnormalities or neoplastic processes."
4.	Acute Erythroblastic Leukemia (Erythroleukemia) 06/02/2006 - "Non-coding transcripts far upstream of the epsilon-globin gene are distinctly expressed in human primary tissues and erythroleukemia cell lines." 01/01/2001 - "K562 is a human erythroleukemia cell line in which the embryonic epsilon-globin gene is predominantly expressed, while the HEL cell line expresses predominantly the fetal beta-globin genes. " 08/01/1992 - "Post-transcriptional regulation by interferon-alpha of epsilon-globin production in human erythroleukemia K-562 cells." 01/14/1986 - "The specificity of expression of the isolated 5'-flanking sequences of the human beta- and epsilon-globin genes was examined in the K562 human erythroleukemia cell line, the murine erythroleukemia (MEL) cell, and in nonerythroid cell lines CV-1, HeLa-S3, and WI-38. " 11/01/1984 - "The human beta-globin gene is expressed--but the human fetal (gamma) and embryonic (epsilon) globin genes are not--in an induced mouse erythroleukemia cell line (M11-X) that contains most of human chromosome 11. "
5.	Hypersensitivity (Allergy) 08/01/2008 - "Loss of GATA-1 in HS2 did not compromise interaction of NF-E2, a second activator that binds to HS2, nor was DNase I hypersensitivity at HS2 or the promoter of a linked epsilon-globin gene altered. " 05/15/1996 - "To understand how the hypersensitivity is generated and maintained, we studied the chicken erythroid-specific beta(A)/epsilon globin gene enhancer, a region where both tissue-specific and ubiquitous transcription factors can bind. " 03/01/1990 - "The human epsilon-globin gene has a number of alternative transcription initiation sites which correspond with regions of DNase I hypersensitivity upstream of the canonical cap site. " 05/07/2010 - "DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice."

Related Drugs and Biologics

1.	beta-Globins (beta Globin)
2.	Deoxyribonuclease I (Nickase)
3.	gamma-Globins
4.	Globins
5.	zeta-Globins
6.	Interferon-alpha (Interferon Alfa)
7.	Transcription Factors (Transcription Factor)
8.	Messenger RNA (mRNA)
9.	DNA-Directed RNA Polymerases (RNA Polymerase)
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Radiotherapy