gamma-Globins

Members of the beta-globin family. In humans, two non-allelic types of gamma-globin - A gamma and G gamma are encoded in the beta-globin gene cluster on CHROMOSOME 11. Two gamma-globin chains combine with two ZETA-GLOBIN chains to form the embryonic hemoglobin Portland. Fetal HEMOGLOBIN F is formed from two gamma-globin chains combined with two ALPHA-GLOBIN chains.

Also Known As:

Networked: 236 relevant articles (11 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Persons, Derek A: 6 articles (09/2010 - 03/2003)
2.	Perrine, Susan P: 5 articles (04/2014 - 12/2002)
3.	Faller, Douglas V: 5 articles (04/2014 - 12/2002)
4.	Stamatoyannopoulos, George: 5 articles (03/2007 - 09/2002)
5.	Pace, Betty S: 4 articles (04/2014 - 12/2002)
6.	Bianchi, Nicoletta: 4 articles (10/2009 - 08/2003)
7.	Borgatti, Monica: 4 articles (10/2009 - 08/2003)
8.	Gambari, Roberto: 4 articles (10/2009 - 08/2003)
9.	Hargrove, Phillip W: 4 articles (06/2009 - 03/2003)
10.	Emery, David W: 4 articles (03/2007 - 09/2002)

Related Diseases

1.	beta-Thalassemia (Cooley's Anemia) 01/01/2008 - "These studies indicate that in beta-thalassemia, KL, alone or combined with Dex, induces an expansion of effective erythropoiesis and the reactivation of gamma-globin genes up to fetal levels and may hence be considered as a potential therapeutic agent for this disease." 10/01/2009 - "To verify the activity of these derivatives, we employed three experimental cell systems: (1) the human leukemic K562 cell line, (2) K562 cell clones stably transfected with a pCCL construct carrying green-EGFP under the gamma-globin gene promoter, and (3) the two-phase liquid culture of human erythroid progenitors isolated from normal donors and beta-thalassemia patients. " 06/04/2009 - "Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene." 01/01/2009 - "The nucleotide (nt) variations in the promoter region of the gamma-globin genes, HS-111 and 3'HS1 regions, were studied in Iranian patients with beta-thalassemia intermedia (beta-TI), beta-thalassemia major (beta-TM) and healthy individuals. " 01/01/2009 - "Molecular analysis of gamma-globin promoters, HS-111 and 3'HS1, in beta-thalassemia intermedia patients associated with high levels of Hb F."
2.	Anemia 12/15/2002 - "These findings identify SCFADs that stimulate gamma globin gene expression and erythropoiesis in vivo, activities that are synergistically beneficial for treatment of the beta hemoglobinopathies and useful for the oral treatment of other anemias." 03/01/1984 - "This may have implications for a better understanding of the variable nature of the expression of sickle cell anemia, because clinically relevant sequences (for example, gamma-globin gene regulatory sequences responsive to anemia) might be linked polymorphically to these haplotypes." 02/01/2009 - "Both vectors demonstrated efficacy in disease correction, with the V5m3 vector producing a higher level of gamma-globin mRNA which was associated with high-level correction of anemia and secondary organ pathology. " 09/01/2010 - "In contrast, animals having high levels of fetal hemoglobin due to gene transfer with a gamma-globin lentiviral vector showed correction of anemia and organ damage. " 06/04/2009 - "This resulted in significant increases in the number of gamma-globin-expressing red cells and the amount of fetal hemoglobin, leading to resolution of anemia. "
3.	Sickle Cell Anemia (Hemoglobin S Disease) 08/01/2007 - "Hence, therapeutic treatment of sickle cell anemia has been focused on introducing gamma-globin gene into red blood cells to increase the cellular gamma/beta(S) ratio. " 08/19/2008 - "Here, we genotyped additional BCL11A SNPs, HBS1L-MYB SNPs, and an SNP upstream of (G)gamma-globin (HBG2; the XmnI polymorphism), in two independent SCD cohorts: the African American Cooperative Study of Sickle Cell Disease (CSSCD) and an SCD cohort from Brazil. " 11/01/1994 - "In this study we have determined the frequency of beta S haplotypes in a Brazilian sickle cell disease population from Sao Paulo, Brazil, by analyzing sequence variations in the immediate 5' flanking and second intervening sequence (IVSII) regions of the gamma globin genes. " 08/01/2010 - "Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients." 08/06/2009 - "A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction."
4.	Hemoglobinopathies 01/01/2009 - "Two healthy newborns, heterozygous for two different gamma-globin chain mutations, were observed during an electrophoretic screening for hemoglobinopathies in Sassari, North Sardinia (Italy). " 05/01/2006 - "Pharmacologic reinduction of the developmentally silenced fetal (gamma) globin genes has been achieved in hemoglobinopathy patients using short chain fatty acid derivatives, with therapeutic effects. " 12/15/2002 - "Orally bioactive compounds that induce gamma globin gene expression at tolerable doses are needed for optimal treatment of the beta-hemoglobinopathies. " 04/01/1999 - "Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette." 01/01/1999 - "If there is a reciprocal elevation of gamma-globin expression upon repression, this approach could be useful in additional hemoglobinopathies. "
5.	Thalassemia 03/01/2005 - "The Corfu deltabeta thalassemia deletion disrupts gamma-globin gene silencing and reveals post-transcriptional regulation of HbF expression." 05/01/2003 - "Herein are results obtained in use of lentiviral vectors to insert a gamma-globin gene into murine stem cells with phenotypic correction of the thalassemia phenotype. " 09/01/1997 - "Following amplification by the polymerase chain reaction and sequencing of the 1.5-kb bridging fragment, we have shown that the 5' breakpoint of the deletion occurs 1260 bp 3' of the fetal G gamma-globin gene, whereas the 3' breakpoint lies 521 bp upstream of the EcoRI site of the enhancer element and 2845 bp upstream of the 3' breakpoint of the Chinese (A gamma delta beta) zero-thalassemia deletion. " 06/01/1996 - "A permanent lymphocyte cell line of a heterozygote with Yunnanese (A gamma delta beta)0-thalassemia deletion, associated with an increased production of G gamma globin in adult, was founded using Epstein-Barr virus transformation. " 06/01/1996 - "Active expression of G gamma globin gene on chromosome 11 with Yunnanese A gamma delta beta)0-thalassemia deletion in MEL cells."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Fetal Hemoglobin (Hemoglobin F)
3.	gamma-Globins
4.	Globins
5.	DNA (Deoxyribonucleic Acid)
6.	Hemoglobins (Hemoglobin)
7.	alpha-Globins
8.	Hemin (Panhematin)
9.	erythroid Kruppel-like factor
10.	Valproic Acid (Valproate, Semisodium)

Related Therapies and Procedures

1.	Investigational Therapies (Experimental Therapy)
2.	Transplants (Transplant)
3.	Therapeutics