beta-Globins (beta Globin)

Members of the beta-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 11. They include epsilon-globin, gamma-globin, delta-globin and beta-globin. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult HEMOGLOBIN is comprised of two ALPHA-GLOBIN chains and two beta-globin chains.

Also Known As:

Networked: 1424 relevant articles (6 outcomes, 91 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fucharoen, Suthat: 12 articles (01/2020 - 08/2002)
2.	Estcourt, Lise J: 10 articles (01/2020 - 04/2016)
3.	Hopewell, Sally: 10 articles (01/2020 - 04/2016)
4.	Trivella, Marialena: 9 articles (01/2020 - 04/2016)
5.	Rivella, Stefano: 8 articles (01/2017 - 03/2002)
6.	Sadelain, Michel: 8 articles (04/2016 - 03/2002)
7.	Fucharoen, Goonnapa: 7 articles (06/2012 - 08/2002)
8.	Fucharoen, Supan: 7 articles (06/2012 - 08/2002)
9.	Steinberg, Martin H: 7 articles (03/2012 - 02/2003)
10.	Vadolas, Jim: 7 articles (09/2009 - 12/2002)

Related Diseases

1.	beta-Thalassemia (Cooley's Anemia) 11/01/2020 - "This study was conducted to investigate beta-thalassemia mutation in the fetus through maternal blood with multiple polymorphisms as haplotypes in the beta-globin gene. " 01/01/2014 - "Molecular analysis of beta-globin gene mutations among Thai beta-thalassemia children: results from a single center study." 01/01/2013 - "Beta-globin Gene Mutations in Turkish Children with Beta-Thalassemia: Results from a Single Center Study." 01/01/2009 - "Although studies on beta-thalassemia major patients showed significant results, but these clinical responses are expected to be more in thalassemia intermedia (TI) patients because of lesser alpha/beta globin imbalance. " 10/01/2006 - "The seven rare beta-globin mutations and a rare haemoglobin variant confirmed in this study have been described in other populations but have not been previously described in Malaysian beta-thalassemia patients."
2.	Sickle Cell Anemia (Hemoglobin S Disease) 04/01/1992 - "The model used in this study is the amplification of a 725 base-pair (bp) beta-globin gene sequence encompassing the sickle-cell anemia point mutation, followed by Cvn I digestion. " 08/09/2023 - "Sickle cell anemia (SCA) is an autosomal recessive disorder caused by a mutation in beta globin gene. " 06/21/2023 - "Sickle cell disease (SCD) is caused by the homozygous beta-globin gene mutation that can lead to ischemic multi-organ damage and consequently reduce life expectancy. " 01/01/2023 - "Sickle cell disease (SCD), one of the commonest severe monogenic disorders, is caused by the inheritance of two abnormal haemoglobin (beta-globin) genes. " 01/01/2023 - "Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant deformation of the red blood cells and variable clinical outcomes. "
3.	Neoplasms (Cancer) 01/01/2008 - "We also discuss how the lessons learned from the study of the effects of these compounds on the beta-globin locus, one of the best characterized regions of the human genome, might contribute to the understanding of the mechanism of action of these same compounds in cancer, where the specific regions of the genome that are responsible for the pathophysiology of the disease are often poorly defined." 04/01/2009 - "Genomic DNAs were isolated from the parafin embedded specimens of tumor and tumor-adjacent normal tissues and the performance of the extraction process was controlled with PCR using beta-globin primer. " 01/01/2009 - "Our clinical trial at Memorial Sloan-Kettering Cancer Center builds on a 20-year long investigation to develop an erythroid-specific vector to regulate beta-globin transgene expression in the progeny of transduced hematopoietic stem cells. " 01/01/2008 - "Fragments of human beta-globin gene, which served as the internal controls, were successfully amplified from 102 of the 129 cancer specimens and from all the normal and fresh cancer tissues, while consensus and type 16-specific primers failed to detect HPV DNA sequences in any of the esophageal samples. " 03/01/2004 - "The prospect of inducing expression of adult (beta) globin gene and apoptosis selectively in cancer cells is obviously attractive from a therapeutic point of view."
4.	Malaria 01/01/2017 - "Beta-globin gene haplotypes and selected Malaria-associated variants among black Southern African populations." 01/12/2016 - "Sickle haemoglobin (HbS) and haemoglobin C (HbC) are both caused by point mutations in the beta globin gene, and both offer substantial malaria protection. " 12/01/2009 - "Our knowledge of malaria prevalence and pathogenesis in wild chimpanzees is severely limited, but it may be the case that beta-globin and G6PD variation are not adaptive in chimpanzees because malaria is rare and/or less detrimental in this species. " 12/01/2009 - "We find no evidence of the major deleterious mutations at HBB (beta-globin) and G6PD in chimpanzees that confer resistance to malaria caused by P. " 01/16/2009 - "Incidence rate ratios with 95% confidence intervals were calculated by Poisson regression to estimate the association of beta-globin genotypes with the number of malaria episodes. "
5.	Neoplasm Micrometastasis 04/01/2008 - "Mutant allele-specific amplification of p53 gene could also detect micrometastasis with almost equal sensitivity of polymerase chain reaction with beta-globin gene. " 01/01/2005 - "Polymerase chain reaction (PCR) targeting human beta-globin gene has been reported to be able to detect micrometastasis in an animal model. " 01/01/2004 - "These findings indicate that UFT is useful for either adjuvant chemotherapy or the inhibition of micrometastasis, and our system to detect micrometastasis by examining the human beta-globin gene is useful for the early evaluation of the efficacy of these drugs." 09/01/1997 - "Circulating tumor cells and micrometastases to organs such as lung, liver, spleen, and omentum were detected for both cell lines by PCR of the human beta-globin gene. " 10/01/2000 - "In nude mice, oral administration of TPI suppressed not only macroscopic liver metastases of highly metastatic KB/TP cells but also the level of human beta-globin as a molecular marker of micrometastases in the livers of the mice. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Globins
3.	Proteins (Proteins, Gene)
4.	Sickle Hemoglobin
5.	Messenger RNA (mRNA)
6.	Codon (Codons)
7.	alpha-Globins
8.	Hemoglobins (Hemoglobin)
9.	DNA Restriction Enzymes (Restriction Endonuclease)
10.	Complementary DNA (cDNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Adjuvant Chemotherapy
3.	Transplantation
4.	Investigational Therapies (Experimental Therapy)
5.	Heterologous Transplantation (Xenotransplantation)