beta-Globins (beta Globin)

Members of the beta-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 11. They include epsilon-globin, gamma-globin, delta-globin and beta-globin. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult HEMOGLOBIN is comprised of two ALPHA-GLOBIN chains and two beta-globin chains.

Also Known As:

Networked: 1215 relevant articles (4 outcomes, 84 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fucharoen, Suthat: 9 articles (09/2009 - 08/2002)
2.	Steinberg, Martin H: 7 articles (03/2012 - 02/2003)
3.	Rivella, Stefano: 7 articles (08/2010 - 03/2002)
4.	Vadolas, Jim: 7 articles (09/2009 - 12/2002)
5.	Malik, Punam: 7 articles (08/2009 - 07/2004)
6.	Sadelain, Michel: 7 articles (01/2009 - 03/2002)
7.	Williamson, Robert: 7 articles (03/2006 - 12/2002)
8.	Fucharoen, Supan: 6 articles (06/2012 - 08/2002)
9.	Fucharoen, Goonnapa: 6 articles (06/2012 - 08/2002)
10.	Cao, Antonio: 6 articles (03/2010 - 09/2002)

Related Diseases

1.	beta-Thalassemia (Cooley's Anemia) 01/01/2014 - "Molecular analysis of beta-globin gene mutations among Thai beta-thalassemia children: results from a single center study." 01/01/2013 - "Beta-globin Gene Mutations in Turkish Children with Beta-Thalassemia: Results from a Single Center Study." 01/01/2009 - "Although studies on beta-thalassemia major patients showed significant results, but these clinical responses are expected to be more in thalassemia intermedia (TI) patients because of lesser alpha/beta globin imbalance. " 10/01/2006 - "The seven rare beta-globin mutations and a rare haemoglobin variant confirmed in this study have been described in other populations but have not been previously described in Malaysian beta-thalassemia patients." 05/01/2005 - "Transgenic mouse colonies with 100% (hu)beta-globin production from the intact (hu)beta-globin locus have been established and will be invaluable in comparative and gene therapy studies with mouse models containing specific beta-thalassemia mutations in the (hu)beta-globin locus."
2.	Sickle Cell Anemia (Hemoglobin S Disease) 04/01/1992 - "The model used in this study is the amplification of a 725 base-pair (bp) beta-globin gene sequence encompassing the sickle-cell anemia point mutation, followed by Cvn I digestion. " 12/01/2013 - "Frequency and origin of haplotypes associated with the beta-globin gene cluster in individuals with trait and sickle cell anemia in the Atlantic and Pacific coastal regions of Colombia." 11/01/2013 - "Sickle cell disease (SCD) is a hemolytic disorder caused by a mutation in beta-globin gene and affects millions of people worldwide. " 06/01/2013 - "The sickle-cell diseases are determined by combinations of two abnormal alleles of beta globin gene including at least one which carries the mutation beta 6 glu-val (Hb S). " 01/01/2013 - "Sickle cell anemia is a genetically inherited disease in which the "SS" individual possesses an abnormal beta globin gene. "
3.	Neoplasms (Cancer) 01/01/2008 - "We also discuss how the lessons learned from the study of the effects of these compounds on the beta-globin locus, one of the best characterized regions of the human genome, might contribute to the understanding of the mechanism of action of these same compounds in cancer, where the specific regions of the genome that are responsible for the pathophysiology of the disease are often poorly defined." 04/01/2009 - "Genomic DNAs were isolated from the parafin embedded specimens of tumor and tumor-adjacent normal tissues and the performance of the extraction process was controlled with PCR using beta-globin primer. " 01/01/2009 - "Our clinical trial at Memorial Sloan-Kettering Cancer Center builds on a 20-year long investigation to develop an erythroid-specific vector to regulate beta-globin transgene expression in the progeny of transduced hematopoietic stem cells. " 01/01/2008 - "Fragments of human beta-globin gene, which served as the internal controls, were successfully amplified from 102 of the 129 cancer specimens and from all the normal and fresh cancer tissues, while consensus and type 16-specific primers failed to detect HPV DNA sequences in any of the esophageal samples. " 09/15/2004 - "The differentially expressed protein of beta-globin was found in normal mucosa and hepatic metastatic tumor, but lost in primary cancer lesion. "
4.	Malaria 12/01/2009 - "Our knowledge of malaria prevalence and pathogenesis in wild chimpanzees is severely limited, but it may be the case that beta-globin and G6PD variation are not adaptive in chimpanzees because malaria is rare and/or less detrimental in this species. " 12/01/2009 - "We find no evidence of the major deleterious mutations at HBB (beta-globin) and G6PD in chimpanzees that confer resistance to malaria caused by P. " 01/01/2009 - "This effect was restricted to children who experienced malaria episodes during the observation period suggesting that the beneficial effect of the beta-globin HbS variant on the incidence of stunting is closely linked to its protection from mild malaria episodes. " 01/01/2009 - "Odds ratios (OR) were calculated for the association between the occurrence of beta-globin genotypes and/or malaria episodes and stunting. " 01/01/2009 - "Incidence rate ratios with 95% confidence intervals were calculated by Poisson regression to estimate the association of beta-globin genotypes with the number of malaria episodes. "
5.	Thalassemia 01/01/2006 - "These studies showed that BP1 can negatively modulate adult beta-globin gene expression and definitive erythroid cell differentiation, and suggest that BP1 could play a role in thalassemia." 01/01/2004 - "The primary aim of this study was the refinement of BIA technology for use in identifying the beta o 39 mutation of the beta-globin gene, a mutation which causes a common type of beta o thalassemia. " 01/01/1990 - "Only one of 50 thalassemia alleles of beta-globin genes under study has been shown to possess the mutation mentioned." 01/01/1988 - "In this study, we investigated the clinical and hematological features and carried out alpha- and beta-globin gene analyses in 11 Sardinian adult beta zero-thalassemia homozygotes from Northern Sardinia who were not transfusion-dependent. " 11/01/2014 - "Thalassemia is an inherited disorder of alpha or beta globin chain synthesis leading to ineffective erythropoiesis requiring chronic transfusion therapy in its most severe form. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Globins
3.	Sickle Hemoglobin
4.	Proteins (Proteins, Gene)
5.	Messenger RNA (mRNA)
6.	alpha-Globins
7.	Codon (Codons)
8.	Hemoglobins (Hemoglobin)
9.	DNA Restriction Enzymes (Restriction Endonuclease)
10.	hemoglobin A2'

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Investigational Therapies (Experimental Therapy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Splenectomy
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)