Cysteine-Rich Protein 61

A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It may play an important role in the development of branched CAPILLARIES during EMBRYOGENESIS.

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Networked: 113 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Chen: 3 articles (12/2021 - 01/2018)
2.	Chen, Yung-Ming: 3 articles (10/2021 - 01/2013)
3.	Lai, Chun-Fu: 3 articles (10/2021 - 01/2013)
4.	Tsai, Tun-Jun: 3 articles (10/2021 - 01/2013)
5.	Song, Yanfang: 3 articles (01/2021 - 02/2019)
6.	Zhu, Xianjin: 3 articles (01/2021 - 02/2019)
7.	Chin, Li-Han: 3 articles (01/2017 - 01/2015)
8.	Hsu, Sung-Po: 3 articles (01/2017 - 01/2015)
9.	Liang, Yu-Chih: 3 articles (01/2017 - 01/2015)
10.	Zhong, Wen-Bin: 3 articles (01/2017 - 01/2015)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 07/01/1998 - "Immunohistochemical analysis showed that Cyr61 protein could be found in the epithelium of normal prostatic tissue, whereas prostate cancer tissue showed a marked decrease of Cyr61 protein expression. " 09/01/2023 - "Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell lines within 2-4 h. "
2.	Neoplasms (Cancer) 01/01/2020 - "Overexpression of CYR61 protein promotes the migration and the transition of tumor-derived vascular endothelial cells in NSCLC. " 07/01/2016 - "CYR61 protein promotes migration and the epithelial-mesenchymal transition in several cancer cell types. " 03/01/2013 - "CYR61 (cysteine-rich protein 61, also named IGFBP10) is a secreted signaling molecule that promotes angiogenesis and tumor growth. " 07/01/2010 - "Cysteine-rich protein 61 (CYR61) is a member of the CCN (CYR61/CTGF/NOV) family, which is associated with progression in a variety of human cancers. " 04/01/2010 - "In 174 matched tumors and normal prostate tissues adjacent to tumor tissue microarray revealed significantly up-regulated Cyr61 protein expression in cancer tissue vs normal prostate tissue adjacent to tumor. "
3.	Neoplasm Metastasis (Metastasis) 03/01/2005 - "Reverse transcription polymerase chain reaction confirmed the microarray results, and immunohistochemistry analysis demonstrated increased Cyr61 protein and persistent alpha(v)beta(3) expression in peritioneal metastases. " 02/01/2019 - "Elevation of Cyr61 protein levels contributes to the proliferation, metastasis, and chemotherapy resistance of malignant cells. " 12/01/2016 - "Cysteine-rich protein 61 (CCN1/Cyr61) has been implicated as an important mediator in the proliferation and metastasis of breast cancer. " 12/01/2013 - "Overexpressed cysteine-rich protein 61 (Cyr61) is believed to enhance osteosarcoma (OS) cell metastasis, but the mechanism of Cyr61 overexpression in OS is not clear so far. " 05/01/2012 - "Cysteine-rich protein 61(CCN1/Cyr61) has been implicated as an important mediator in proliferation and metastasis of breast cancer, which indicated that blockage of Cyr61 might be a potent target for breast cancer treatment. "
4.	Inflammation (Inflammations) 01/01/2018 - "A functional characteristic of cysteine-rich protein 61: Modulation of myeloid-derived suppressor cells in liver inflammation." 03/04/2014 - "M1 macrophage-dominant inflammation was present in the S group, and cysteine-rich protein 61 (Cyr61), an inducer of M1 macrophages, was markedly upregulated in these spinal cords. " 01/01/2013 - "CCN1 protein and overexpression of CCN1 in the liver induced more severe hepatic inflammation and macrophage infiltrates in HF mice than in ND mice. " 11/01/2020 - "The aim of the study is to demonstrate the role of cysteine-rich protein 61 (CYR61), a novel proinflammatory factor, in the inflammation and fibrosis of TAK vessels. " 09/01/2014 - "Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury."
5.	Carcinoma (Carcinomatosis) 08/01/2014 - "Moreover, receiver operating characteristic (ROC) curve analysis, Spearman's rank correlation, Kaplan-Meier plots, and the Cox proportional hazards regression model were used to investigate the potential association of the CYR61 protein with the development of ovarian carcinoma in an ovarian carcinoma cohort. " 08/01/2013 - "Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells." 07/01/2010 - "Our previous study confirmed that the expression levels of CYR61 protein were decreased in gastric carcinoma compared to non-tumoral mucosa as determined by proteome analysis. " 08/01/2014 - "Our results suggest that the CYR61 protein is an important and independent biomarker for prognostic implications of ovarian carcinoma." 08/01/2012 - "To investigate the relationship between cysteine-rich protein 61 (Cyr61) and phosphatidylinositol 3-kinase (PI3K) signal pathway on cell proliferation and apoptotic in human ovarian carcinoma cells. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Connective Tissue Growth Factor
4.	Biomarkers (Surrogate Marker)
5.	Epidermal Growth Factor (EGF)
6.	Cysteine (L-Cysteine)
7.	Interleukin-6 (Interleukin 6)
8.	Proteome
9.	Vimentin
10.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)