Nephroblastoma Overexpressed Protein

A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.

Also Known As:

Networked: 22 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Perbal, Bernard: 8 articles (10/2009 - 03/2002)
2.	Naus, Christian C: 2 articles (10/2009 - 08/2004)
3.	Planque, Nathalie: 2 articles (10/2009 - 09/2006)
4.	Lazar, Noureddine: 2 articles (02/2008 - 01/2008)
5.	Hazelgrove, Katie: 1 article (12/2021)
6.	An, Yongbo: 1 article (03/2021)
7.	Jin, Lan: 1 article (03/2021)
8.	Li, Jun: 1 article (03/2021)
9.	Wang, Dong: 1 article (03/2021)
10.	Wang, Jin: 1 article (03/2021)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2002 - "Although previous studies have revealed an expression of CCN3 protein in several normal tissues, including kidney, nervous system, lung, muscle, and cartilage, less is known about its expression in tumors. " 01/01/2006 - "The CCN3 protein and cancer." 06/01/1998 - "In Wilms' tumors exhibiting heterotypic differentiation, novH protein was expressed at high levels in tumor-derived striated muscle and at lower levels in tumor-derived cartilage. " 06/01/1998 - "As in developing kidney podocytes, novH protein was also prominent in the abnormal hypoplastic podocytes from DDS cases and in kidney podocytes adjoining Wilms' tumors. " 01/01/2008 - "Truncated CCN3 protein in Wilms' tumor cells may provide evidence for its tumorigenic role in these tumors. "
2.	Wilms Tumor (Wilm's Tumor) 05/01/2008 - "The CCN3 protein (Nov, Nephroblastoma overexpressed) is a member of the CCN family (Cyr61, CTGF, Nov) of growth regulators and exerts antiproliferative properties. " 08/16/2002 - "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway." 04/21/2023 - "Nephroblastoma overexpressed (NOV/CCN3) protein has been identified in multiple chronic inflammatory states, most notably in obesity and more recently in OSA, even in the absence of obesity. " 01/01/2008 - "Truncated CCN3 protein in Wilms' tumor cells may provide evidence for its tumorigenic role in these tumors. " 01/01/2008 - "Our data suggest expression of a truncated nuclear CCN3 variant lacking the thrombospondin type-1-like domain and cytoplasmic full-length CCN3 protein in Wilms' tumor cells. "
3.	Obesity 04/21/2023 - "Nephroblastoma overexpressed (NOV/CCN3) protein has been identified in multiple chronic inflammatory states, most notably in obesity and more recently in OSA, even in the absence of obesity. " 08/01/2019 - "Nephroblastoma overexpressed protein, also called NOV/CCN3, is an adipokine which is present in various tissues and recently linked to obesity. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "Nephroblastoma overexpressed protein (NOV/CCN3), the early discovered member of the CCN family, has recently been suggested to be involved in a number of inflammatory processes, including wound healing, alveolar epithelial cell inflammation, cancer metastasis, and macrophage foam cell formation. " 02/01/2008 - "Analysis of CCN3 protein expression with respect to melanoma progression detected the protein in all visceral metastases tested and in most nodal metastases from relapsing patients but in only a few nodal metastases from nonrelapsing patients and cutaneous metastases. "
5.	Glioma (Gliomas) 08/15/2007 - "Here we show that native CCN3 protein secreted into the conditioned medium of glioma transfected cells indeed induces a reduction in cell proliferation. " 08/27/2004 - "Western blot analysis demonstrated that the 48-kDa full-length CCN3 protein was present in the lysate and conditioned medium of growth-suppressed C6-Cx43 cells, as well as primary astrocytes, but not in C6 parental and human glioma cells. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Conditioned Culture Media
3.	Connective Tissue Growth Factor
4.	Adipokines
5.	Caspase 8 (Caspase-8)
6.	Caspase 3 (Caspase-3)
7.	Thrombospondins
8.	Biomarkers (Surrogate Marker)
9.	Messenger RNA (mRNA)
10.	Paraffin