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Connective Tissue Growth Factor

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A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.

Also Known As:

CCN2 Protein; Hypertrophic Chondrocyte-Specific Protein 24; IGF-Binding Protein-Related Protein-2; IGFBP-8; IGFBP-rP2; Insulin-Like Growth Factor Binding Protein 8; Hypertrophic Chondrocyte Specific Protein 24; IGF Binding Protein Related Protein 2; Insulin Like Growth Factor Binding Protein 8

Networked: 1103 relevant articles (14 outcomes, 88 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Goldschmeding, Roel: 33 articles (11/2015 - 10/2002)
2.	Leask, Andrew: 27 articles (11/2015 - 01/2002)
3.	Brigstock, David R: 20 articles (09/2015 - 01/2002)
4.	Takigawa, Masaharu: 17 articles (06/2014 - 05/2002)
5.	Nguyen, Tri Q: 16 articles (08/2015 - 01/2006)
6.	Schultz, Gregory S: 13 articles (06/2015 - 09/2002)
7.	Oliver, Noelynn: 13 articles (07/2011 - 03/2004)
8.	Kubota, Satoshi: 12 articles (06/2012 - 05/2002)
9.	Twigg, Stephen M: 10 articles (06/2013 - 07/2002)
10.	Blalock, Timothy D: 10 articles (11/2005 - 09/2002)

Related Diseases

1.	Fibrosis (Cirrhosis) 11/01/2015 - "HDAC inhibition prevented this significant decrease 2 weeks post TAC and maintained miR-133a expression near vehicle control levels, which coincided with (1) a decrease in connective tissue growth factor expression, (2) a reduction in cardiac fibrosis and left atrium diameter (marker of end-diastolic pressure), suggesting an improvement in diastolic function. " 06/01/2004 - "Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis." 01/01/2016 - "In this study, we aimed to analyze the changes in the expression of fibrosis-related factors, including transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), and α-smooth muscle actin (α-SMA) in denervated skeletal muscles using a mouse model of accessory nerve transection. " 01/01/2015 - "The aim of this study is to investigate whether the expression levels of fibrosis-related genes, especially that of connective tissue growth factor (CTGF), are altered in orbital fibroblasts of patients with GO. " 07/01/2008 - "Previous studies have shown that connective tissue growth factor (CTGF) plays a key role in the fibrosis process of many tissues and organs, such as kidney and lung. "
2.	Diabetic Nephropathies (Diabetic Nephropathy) 08/01/2010 - "This report summarizes the first phase 1 trial treating patients with microalbuminuric diabetic kidney disease (DKD) using FG-3019, a human monoclonal antibody to connective tissue growth factor (CTGF). " 01/01/2015 - "Connective tissue growth factor (CTGF; CCN2) plays a role in the development of diabetic nephropathy (DN). " 01/01/2015 - "Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction." 01/01/2013 - "Connective tissue growth factor, matrix regulation, and diabetic kidney disease." 04/01/2012 - "Connective tissue growth factor (CTGF) plays a pathogenic role in diabetic nephropathy (DN). "
3.	Cardiomegaly (Heart Hypertrophy) 01/01/2009 - "Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload." 05/30/2008 - "Connective tissue growth factor induces cardiac hypertrophy through Akt signaling." 01/01/2015 - "Adenovirus-mediated CTRP6 delivery improved cardiac function, attenuated cardiac hypertrophy, alleviated cardiac fibrosis, and inhibited myofibroblast differentiation as well as the expression of collagen I, collagen III, and connective tissue growth factor post-MI. " 09/20/2005 - "The GK rats developed hypertension, cardiac hypertrophy and overexpression of cardiac natriuretic peptides and profibrotic connective tissue growth factor compared to nondiabetic Wistar rats. " 07/01/2011 - "Cardiac functions were studied by echocardiography, hemodynamic measurements, histological analysis of fibrosis and cardiac hypertrophy, and by quantitative real time PCR analysis of atrial natriuretic peptide (Nppa), periostin (Postn), connective tissue growth factor (Ctgf) and β-myosin heavy chain (Myh7). "
4.	Neoplasm Metastasis (Metastasis) 07/01/2015 - "Connective tissue growth factor inhibits gastric cancer peritoneal metastasis by blocking integrin α3β1-dependent adhesion." 03/01/2014 - "This paper shows that BMP9 inhibit the bone metastasis of breast cancer cells by activating the BMP/Smad signaling pathway and downregulating connective tissue growth factor (CTGF); however, when CTGF expression was maintained, the inhibitory effect of BMP9 on the MDA-MB-231 cells was abolished. " 03/01/2014 - "BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression." 03/01/2014 - "Connective tissue growth factor (CTGF/CCN2) is involved in extracellular matrix production, tumor cell proliferation, adhesion, migration, and metastasis. " 01/01/2013 - "Connective-tissue growth factor (CTGF/CCN2) is a matricellular-secreted protein involved in complex processes such as wound healing, angiogenesis, fibrosis and metastasis, in the regulation of cell proliferation, migration and extracellular matrix remodeling. "
5.	Rheumatoid Arthritis 06/01/2013 - "Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis." 06/01/2015 - "We have shown that connective tissue growth factor (CTGF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). " 11/18/2014 - "Inhibition of rheumatoid arthritis by blocking connective tissue growth factor." 06/01/2013 - "We have shown that connective tissue growth factor (CTGF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). " 01/01/2012 - "The detection of plasma levels of connective tissue growth factor in rheumatoid arthritis patients."

Related Drugs and Biologics

1.	Collagen
2.	Transforming Growth Factors (Transforming Growth Factor)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Transforming Growth Factor beta1 (TGF beta 1)
5.	Transforming Growth Factor beta (TGF-beta)
6.	Fibronectins (Fibronectin)
7.	Osteopontin
8.	Tissue Inhibitor of Metalloproteinase-1
9.	Matrix Metalloproteinases
10.	Brain Natriuretic Peptide (Natrecor)

Related Therapies and Procedures

1.	Filtering Surgery
2.	Heterologous Transplantation (Xenotransplantation)
3.	Intravitreal Injections
4.	Renal Dialysis (Hemodialysis)
5.	Homologous Transplantation (Allograft)