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Insulin Receptor Substrate Proteins

A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
Also Known As:
IRS Signaling Adaptor Proteins; Insulin Receptor Substrate-1; Insulin Receptor Substrate-1 Protein; Insulin Receptor Substrate-2; Insulin Receptor Substrate-2 Protein; Insulin Receptor Substrate-3; Insulin Receptor Substrate-3 Protein; Insulin Receptor Substrate-4; Insulin Receptor Substrate-4 Protein; Insulin Receptor Substrate 1; Insulin Receptor Substrate 1 Protein; Insulin Receptor Substrate 2; Insulin Receptor Substrate 2 Protein; Insulin Receptor Substrate 3; Insulin Receptor Substrate 3 Protein; Insulin Receptor Substrate 4; Insulin Receptor Substrate 4 Protein
Networked: 1023 relevant articles (32 outcomes, 102 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. White, Morris F: 18 articles (01/2021 - 01/2002)
2. Terauchi, Yasuo: 13 articles (01/2020 - 11/2002)
3. Kadowaki, Takashi: 13 articles (12/2018 - 11/2002)
4. Shaw, Leslie M: 8 articles (01/2019 - 11/2004)
5. Sesti, Giorgio: 7 articles (05/2011 - 05/2002)
6. Zhang, Yan: 6 articles (12/2019 - 02/2013)
7. Kubota, Naoto: 6 articles (01/2017 - 06/2003)
8. Suzuki, Ryo: 6 articles (06/2006 - 06/2003)
9. Tobe, Kazuyuki: 6 articles (06/2006 - 06/2003)
10. Djordjevic, Ana: 5 articles (01/2021 - 09/2014)

Related Diseases

1. Insulin Resistance
2. Glucose Intolerance
3. Type 2 Diabetes Mellitus (MODY)
4. Obesity
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Insulin (Novolin)
2. Glucose (Dextrose)
3. Interleukin-6 (Interleukin 6)
4. Proteins (Proteins, Gene)
5. Phosphotransferases (Kinase)
6. Facilitative Glucose Transport Proteins (Glucose Transporter)
7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8. NF-kappa B (NF-kB)
9. Insulin Receptor
10. Leptin

Related Therapies and Procedures

1. Resistance Training
2. Injections
3. Reducing Diet
4. Diet Therapy (Therapy, Diet)
5. Electroacupuncture