Catheter-Related Infections

Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.

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Networked: 811 relevant articles (59 outcomes, 81 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Sepsis (Septicemia)
3.	Bacteremia
4.	Neoplasms (Cancer)
5.	Wounds and Injuries (Trauma)

Experts

1.	Timsit, Jean-François: 10 articles (11/2015 - 10/2007)
2.	Lucet, Jean-Christophe: 8 articles (11/2015 - 03/2009)
3.	Lok, Charmaine E: 8 articles (01/2014 - 01/2003)
4.	Bouadma, Lila: 7 articles (11/2015 - 03/2009)
5.	Schwebel, Carole: 7 articles (05/2015 - 03/2009)
6.	Mermel, Leonard A: 7 articles (08/2010 - 06/2002)
7.	Garrouste-Orgeas, Maïté: 6 articles (05/2015 - 03/2009)
8.	Lorente, Leonardo: 6 articles (01/2014 - 01/2005)
9.	Martín, María M: 6 articles (01/2014 - 01/2005)
10.	Lepape, Alain: 5 articles (11/2015 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Catheter-Related Infections:

1.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/2008 - "A total of three studies were found which addressed the role of prophylactic antibiotics to prevent catheter-related infection in neonates. " 10/01/2007 - "This study suggests that the duration of treatment against catheter-related infection by Gram-negative bacilli can be reduced to 3-5 days when using antibiotics to which the organisms are susceptible in vitro, even at a concentration of 1 mg/mL." 01/01/2013 - "There was no benefit to administering antibiotics before the insertion of long-term CVCs to prevent Gram positive catheter-related infections. " 01/01/2011 - "Clinical practice guidelines recommend empiric antibiotic therapy for suspected tunnelled haemodialysis catheter-related infections (CRI), and the choice of antibiotics should be adjusted according to the local microbiological profile and antimicrobial sensitivities. " 12/01/2010 - "This retrospective review compared the rate of catheter-related infections (CRIs) with and without perioperative antibiotics. "
2.	Rifampin (Rifampicin)FDA LinkGeneric 08/01/1991 - "The catheter-related infection rate in rifampin-treated patients was .26 per patient-year versus .93 per patient-year in untreated patients. " 08/01/1991 - "We conclude that intermittent rifampin administration is effective in decreasing catheter-related infections in a peritoneal dialysis population." 09/01/2010 - "Rifampicin-based impregnated catheters seem to be better for prevention of catheter-related infection compared with the other catheters." 10/01/2008 - "In hemodialysis centre a combination of rifampin mixed with protamine is commonly used in some centre in order to prevent catheter related infections in hemodialysis patients. " 08/01/1991 - "Since catheter-related infections are associated with nasal carriage of Staphylococcus aureus in this population, we studied the effect of intermittent rifampin, an antibiotic known to decrease S aureus nasal carriage, on catheter-related infections and peritonitis. "
3.	ChlorhexidineIBA 10/01/2009 - "The introduction of chlorhexidine was followed by a profound, sustained fall in catheter-related infections. " 07/22/2009 - "Chlorhexidine-impregnated sponges and prevention of catheter-related infections." 07/22/2009 - "Chlorhexidine-impregnated sponges and prevention of catheter-related infections." 01/01/2012 - "The randomized two-way factorial Dressing Study (1,636 patients, 28,931 catheter days) showed that a chlorhexidine-impregnated sponge decreased the incidence of major catheter-related infections from 1.4‰ to 0.6‰ catheter days, and that scheduled dressing changes every 7 days was not inferior to scheduled changes every 3 days. " 11/01/2012 - "Although the use of chlorhexidine-impregnated catheters has reduced catheter-related infections, chlorhexidine-resistant Staphylococcus aureus has emerged. "
4.	Heparin (Liquaemin)FDA LinkGeneric 11/01/2001 - "Clinical trials using new materials such as covalently linked heparin on the CVC surface, electrically charged CVC, novel topical agents that interfere with bacterial colonization, antiadhesin molecules and agents that block the gene expression involved in the biofilm formation, are all needed to reduce the high catheter-related infection risk among HIV+ patients." 04/01/2013 - "The use of antimicrobial/antiseptic-impregnated and/or heparin-impregnated CVCs is recommended to decrease the risk of catheter-related infections for short-term CVCs, particularly in high-risk groups; more research is needed. " 12/01/2011 - "Infection control records revealed two periods of increased catheter-related infections, corresponding with two intervals when preservative-free heparin was used at SJCRH. " 12/01/2011 - "There is little published evidence regarding whether heparin lock solutions containing preservatives prevent catheter-related infections. " 12/01/2009 - "[Administration of low-dose heparin in total nutrient admixture prevents central venous catheter-related infections in neonates]."
5.	SilverIBA 11/01/1998 - "In conclusion, our study does not show any benefit of the silver ring in preventing catheter-related infections in PD patients. " 07/01/1996 - "Previous studies have shown that silver formulations coated onto implantable materials retard bacterial colonization and reduce the incidence of catheter-related infections. " 11/01/1998 - "To establish whether a silver ring device (designed by Grosse-Siestrup in 1992) mounted onto the PD catheter and placed at the exit site at skin level is effective in preventing exit-site and other catheter-related infections, a prospective 12-month, multicenter, controlled study stratified by diabetes status was conducted. " 12/01/1995 - "We conclude that this new silver-coated central venous catheter is biocompatible and effective in reducing the incidence of catheter-related infections in oncological patients." 09/01/1995 - "To determine if an attachable silver-impregnated cuff is effective in reducing subclavian hemodialysis catheter-related infections. "
6.	VancomycinFDA LinkGeneric 01/01/1989 - "This study suggests an alternative method for delivering vancomycin when treating a catheter-related infection. " 06/01/2003 - "vancomycin) to prevent catheter-related infection cannot be recommended. " 02/01/1996 - "Use of vancomycin in central venous catheter-related infections." 03/01/2009 - "Vancomycin flush as antibiotic prophylaxis for early catheter-related infections: a cost-effectiveness analysis." 03/01/2004 - "We previously reported that vancomycin in hyperalimentation solution reduces catheter-related infections in the neonatal intensive care unit. "
7.	Minocycline (Cyclops)FDA LinkGeneric 11/01/1999 - "Vascular catheters impregnated with minocycline and rifampin (M/R) were found to be highly efficacious in preventing catheter-related infections. " 04/01/2003 - "The authors examined the efficacy of EVD catheters impregnated with minocycline and rifampin in preventing these catheter-related infections. " 11/01/2003 - "Minocycline-EDTA (M-EDTA) flush solution has been shown to prevent catheter-related infection and colonization in a rabbit model and in hemodialysis patients. " 04/01/2003 - "The use of EVD catheters impregnated with minocycline and rifampin can significantly reduce the risk of catheter-related infections." 10/01/2003 - "To determine the efficacy of minocycline-rifampin-coated hemodialysis catheters in reducing catheter-related infections in patients requiring hemodialysis for acute renal failure. "
8.	Silver Sulfadiazine (SSD)FDA LinkGeneric 04/01/2005 - "Reduction of catheter-related infections in neutropenic patients: a prospective controlled randomized trial using a chlorhexidine and silver sulfadiazine-impregnated central venous catheter." 03/01/2003 - "We assessed the methodological trial quality of individual randomized controlled studies on chlorhexidine silver sulfadiazine impregnated catheters and the effect on catheter-related infection (CRI). " 10/01/1996 - "Phase 2: The rate of catheter-related infection was determined for a trial group of triple-lumen catheters impregnated with silver sulfadiazine and chlorhexidine. " 10/18/2005 - "Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections: a randomized, controlled trial." 05/01/2004 - "Prevention of intravascular catheter-related infection with newer chlorhexidine-silver sulfadiazine-coated catheters: a randomized controlled trial."
9.	Ethanol (Ethyl Alcohol)IBA 05/01/2015 - "Clinical studies of ethanol lock to prevent catheter-related infections (CRIs) suggest preventive efficacy. " 01/01/2013 - "The ethanol lock technique has shown great potential to eradicate organisms in biofilms and to treat or prevent central venous catheter related infections. " 10/01/2006 - "Patients Forty children with diverse underlying disorders were treated for 51 catheter-related infections using the Childrens Hospital Los Angeles ethanol-lock technique. " 02/01/2010 - "Antibiotic-coated catheters and antibiotic or ethanol locks can be implemented, as they appear effective in reducing catheter-related infection and thus further reduce the risk of IFALD. " 05/01/2006 - "Therefore, the ethanol/TSC lock shows promise as a new catheter locking solution for the treatment of catheter-related infections. "
10.	Mupirocin (Bactroban)FDA LinkGeneric 01/01/2008 - "The results of this study will help determine if the use of P3 is superior to mupirocin ointment in the prevention of catheter-related infections and will help guide evidence-based best practices." 01/01/2000 - "We conclude that mupirocin application provides excellent prophylaxis for catheter-related infections owing to S. " 07/01/1997 - "Stepwise logistic regression revealed that cutaneous colonization at the insertion site of at least 10(3) cfu/mL/25 cm(2) (OR 2.6; CI 1.0 to 6.9) and the use of placebo (OR 3.3; CI 1.2 to 9.0) were significant factors predicting local catheter-related infection; whereas mupirocin was associated with reciprocal protective effect (OR 0.3; 95% CI 0.1 to 0.8). " 01/01/2010 - "Mupirocin ointment reduced the risk of catheter-related bacteraemia (RR 0.17, 95%CI 0.07 to 0.43) and had a significant effect on catheter-related infections caused by S. " 01/01/2000 - "The effectiveness of mupirocin preventing Staphylococcus aureus in catheter-related infections in peritoneal dialysis."

Therapies and Procedures

1.	Catheters 09/01/2000 - "The data indicate that the use of the new catheter hub device is no more effective in preventing catheter-related infection than standard good clinical procedures." 04/01/1991 - "In patients with suspected catheter-related infection whose peripheral blood cultures do not grow the same organism as a blood culture drawn from the catheter, a guidewire exchange of the catheter has been shown to be effective. " 01/01/1993 - "Other approaches to reducing catheter-related infections include improved training of personnel in catheter insertion and the development of new materials and methods in cannula production." 01/01/2013 - "To assess the efficacy of antimicrobial-impregnated catheters in preventing catheter-related infections during external ventricular drainage (EVD), we performed a meta-analysis and systematic review. " 06/01/2006 - "We were interested in studying whether improved hygiene during insertion and care of these catheters in the hospice or home environment would reduce the incidence of catheter-related infections. "
2.	Renal Dialysis (Hemodialysis) 10/01/2003 - "The LifeSite Hemodialysis Access System was recently introduced as a completely subcutaneous device with reported advantages of improved patient comfort and reduced catheter-related infection. " 09/01/2015 - "Hemodialysis catheter-related infection: prophylaxis, diagnosis and treatment." 07/01/2014 - "Reducing catheter-related infections in hemodialysis patients." 07/01/2014 - "The purposes of this work were to genetically characterize a group of MRSA isolates from catheter-related infections of ambulatory Mexican hemodialysis patients and to determine whether the strains are the same as those carried by the patients in their anterior nares. " 01/01/2014 - "Approach to prophylactic measures for central venous catheter-related infections in hemodialysis: a critical review."
3.	Drug Therapy (Chemotherapy) 07/01/2013 - "The catheter related infection caused by Staphylococcus epidermidis biofilm is increasing and difficult to treat by antimicrobial chemotherapy. " 08/01/2012 - "Incidence of non-tunnelled central venous catheter-related infections in oncologic patients receiving chemotherapy in an outpatient setting." 04/01/2002 - "Less frequent catheter dressing changes decrease local cutaneous toxicity of high-dose chemotherapy in children, without increasing the rate of catheter-related infections: results of a randomised trial." 10/01/2008 - "Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. " 08/01/2014 - "After chemotherapy, he contracted a catheter-related infection with a high fever up to 41℃ leading to monomorphic VT. "
4.	Peritoneal Dialysis 01/01/1991 - "The current study reports the effect of a program of aggressive nutrition, started in 1/1988, on catheter-related infection rates in children undergoing chronic peritoneal dialysis. " 06/01/2013 - "Catheter related infection due to Mycobacterium abscessus in a patient under peritoneal dialysis." 10/01/2001 - "Catheter-related infections remain a serious problem for patients on peritoneal dialysis. " 04/01/2000 - "Ultrasound diagnosis of catheter related infections in patients on peritoneal dialysis is easy to perform diagnostic procedure which enables more precise diagnosis and better follow-up of therapy. " 12/01/1998 - "Peritoneal dialysis catheter related infections in children."
5.	Intensive Care (Surgical Intensive Care) 01/01/2009 - "Centers for Disease Control and Prevention guidelines for preventing central venous catheter-related infection: results of a knowledge test among 3405 European intensive care nurses." 05/18/2008 - "[Intensive care nurses' knowledge about the evidence-based guidelines of preventing central venous catheter related infection]." 10/01/2007 - "Risk factors for central venous catheter-related infections in pediatric intensive care." 11/01/2005 - "[Predictive value of pericatheter skin cultures in detecting catheter-related infections in a medical-surgical intensive care unit]." 01/01/2004 - "Catheter-related infections in continuous hemodiafiltration in intensive care patients."