Nodal Protein

The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dezi, Lindsay: 1 article (10/2021)
2.	Gillette, Megan: 1 article (10/2021)
3.	Sidor, Julia: 1 article (10/2021)
4.	Strizzi, Luigi: 1 article (10/2021)
5.	Untiveros, Gustavo: 1 article (10/2021)
6.	Goel, Apul: 1 article (04/2015)
7.	Jaiswal, Praveen Kumar: 1 article (04/2015)
8.	Mittal, R D: 1 article (04/2015)
9.	Appeltshauser, Luise: 1 article (01/2015)
10.	Brophy, Peter: 1 article (01/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/20/2008 - "Grappling with emerging new signaling circuits in survivin biology, and their implications in cancer, will further our understanding of this nodal protein, and open fresh opportunities for translational oncology research." 04/01/2015 - "The differential expression of survivin in cancer cells compared to normal tissues and its role as a nodal protein in a number of cellular pathways make it a high target for different therapeutics. " 04/06/2011 - "Survivin's differential expression in cancer compared to normal tissue and its role as a nodal protein in a number of cellular pathways make it a highly flexible therapeutic target, suitable for small-molecule inhibitiors, molecular antagonists, and vaccination-based therapies. " 01/01/2014 - "Nodal protein was expressed in 70 of the 96 (72.9%) HCC tumors, and was associated with vascular invasion (P = 0.000), status of metastasis (P = 0.004), AFP (P = 0.049), ICGR15 (indocyanine green retention rate at 15 min) (P = 0.010) and tumor size (P = 0.000). "
2.	Melanoma (Melanoma, Malignant) 10/29/2021 - "Additional WB analysis showed increased levels of Nodal protein and signaling and signs of increased Wnt activity in the co-cultured melanoma cells compared to reference cells. " 04/01/2010 - "Nodal protein localized diffusely to melanoma cell membranes, with occasional foci of accentuated reactivity in patterns suggestive of channel formation. " 04/01/2010 - "However, given the secretory nature of Nodal protein and melanoma cell heterogeneity, it remains unclear whether the Nodal-expressing cells participate directly or indirectly in VM that is potentially related to tumorigenic growth. "
3.	Polyneuropathies (Polyneuropathy) 01/01/2015 - "Auto-antibodies against the paranodal proteins contactin-1 and neurofascin-155 and the nodal protein neurofascin-186 have been detected in subgroups of patients with chronic inflammatory demyelinating polyneuropathy. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2014 - "Nodal protein was expressed in 70 of the 96 (72.9%) HCC tumors, and was associated with vascular invasion (P = 0.000), status of metastasis (P = 0.004), AFP (P = 0.049), ICGR15 (indocyanine green retention rate at 15 min) (P = 0.010) and tumor size (P = 0.000). "
5.	Glioma (Gliomas) 10/01/2013 - "Nodal protein expression was shown to be correlated with expression levels of glucose transporter (Glut)-1, hexokinase (HK)-II, pyruvate dehydrogenase kinase (PDK)-1, the phosphorylation level of pyruvate dehydrogenase (PDH), glucose uptake, and lactate accumulation in human glioma cells. "

Related Drugs and Biologics

1.	Survivin
2.	Facilitative Glucose Transport Proteins (Glucose Transporter)
3.	Lactic Acid (Lactate)
4.	Pyruvic Acid (Pyruvate)
5.	Proteins (Proteins, Gene)
6.	Oxidoreductases (Dehydrogenase)
7.	Indocyanine Green (Cardio-Green)
8.	Hexokinase
9.	Glucose (Dextrose)
10.	Antibodies

Related Therapies and Procedures

1.	Therapeutics