Growth Differentiation Factor 1

A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chan, A W: 1 article (04/2016)
2.	Chan, F K L: 1 article (04/2016)
3.	Chan, M W Y: 1 article (04/2016)
4.	Chen, J: 1 article (04/2016)
5.	Cheng, A S L: 1 article (04/2016)
6.	Chou, J-L: 1 article (04/2016)
7.	Kang, W: 1 article (04/2016)
8.	Li, M S M: 1 article (04/2016)
9.	Mok, M T S: 1 article (04/2016)
10.	Ng, E K W: 1 article (04/2016)

Related Diseases

1.	Infarction (Infarctions) 07/01/2015 - "Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction." 11/01/2022 - "Growth differentiation factor 1 (GDF1) is a member of the transforming growth factor-β (TGF-β) superfamily and a protective mediator against the development of post-infarction cardiac remodeling by negatively regulating MEK-ERK1/2 and Smad signaling pathways in the heart. "
2.	Stable Angina 11/01/2022 - "Low plasma growth/differentiation factor 1 levels are associated with liver fibrosis in patients with stable angina."
3.	Heterotaxy Syndrome 07/15/2010 - "Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1)."
4.	Neoplasms (Cancer) 04/21/2016 - "We uncovered that growth/differentiation factor 1 (Gdf1), a member of the transforming growth factor-β superfamily, was silenced by promoter hypermethylation in control tumor-bearing mice, but became reactivated in 5-aza-dC-treated mice (P < 0.05). "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 11/01/2022 - "Low plasma growth/differentiation factor 1 levels are associated with liver fibrosis in patients with stable angina."

Related Drugs and Biologics

1.	Transforming Growth Factors (Transforming Growth Factor)
2.	Mitogen-Activated Protein Kinase Kinases (MEKs)