Growth Differentiation Factor 15

A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.

Also Known As:

Networked: 253 relevant articles (7 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wollert, Kai C: 34 articles (09/2015 - 02/2006)
2.	Kempf, Tibor: 34 articles (11/2014 - 02/2006)
3.	Breit, Samuel N: 16 articles (12/2012 - 03/2003)
4.	Brown, David A: 15 articles (12/2012 - 03/2003)
5.	Wallentin, Lars: 13 articles (11/2014 - 02/2007)
6.	Lindahl, Bertil: 8 articles (12/2015 - 02/2007)
7.	Siegbahn, Agneta: 7 articles (12/2015 - 10/2007)
8.	Drexler, Helmut: 7 articles (10/2010 - 02/2006)
9.	Allhoff, Tim: 7 articles (10/2010 - 02/2007)
10.	Peter, Timo: 7 articles (02/2010 - 02/2007)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2015 - "Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells." 05/10/2011 - "Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer." 04/01/2010 - "These data suggest that the use of GDF-15 activated signaling pathways may allow improved chemoprevention and therapies for colorectal cancer." 09/01/2015 - "Based on an analysis of blood and colorectal tumor samples from 2 large studies, high plasma levels of MIC1 (growth differentiation factor 15) before diagnosis of CRC are associated with greater CRC-specific mortality, particularly in individuals with PTGS2-positive tumors." 09/01/2015 - "Patients with colorectal cancer (CRC) have high circulating levels of macrophage inhibitory cytokine-1 (MIC1 or growth differentiation factor 15), a marker of inflammation that might be involved in carcinogenesis. "
2.	Insulin Resistance 02/01/2011 - "Nevertheless, GDF-15 changes following bariatric surgery suggest an indirect relationship between GDF-15 and insulin resistance. " 11/01/2012 - "GDF-15 was related to body weight, BMI, waist-to-hip ratio, and insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR)) (all P < 0.01). " 11/01/2012 - "Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial." 11/01/2012 - "We assessed whether GDF-15 can predict future insulin resistance and impaired glucose control in obese nondiabetic individuals. " 02/01/2011 - "The associations between circulating GDF-15 concentrations and age, insulin resistance, and creatinine might account for the additional cardiovascular predictive information of GDF-15 compared to traditional risk factors. "
3.	Neoplasm Metastasis (Metastasis) 03/01/2014 - "Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis." 12/01/2012 - "New GDF-15 roles have recently been identified for modulating osteoclast differentiation and for therapy for PCa bone metastases. " 06/01/2012 - "Further data collection and analysis are necessary to evaluate a possible prognostic role of GDF-15 in predicting early metastases." 06/01/2012 - "Patients with clinically detectable metastases had significantly higher GDF-15 serum levels compared to those without clinically detectable metastases as well as to healthy individuals (ANOVA; p < 0.001). " 06/01/2012 - "GDF-15 concentration was measured using an enzyme-linked immunosorbent assay (ELISA) in serum samples from 188 UM patients (170 patients without metastases; 18 patients with clinically detectable metastases) and 18 healthy control individuals. "
4.	Chest Pain (Chest Pains) 02/01/2012 - "GDF-15 predicts all-cause mortality in unselected patients with acute chest pain independently of and more accurately than hs-cTnT and BNP. " 10/01/2008 - "GDF-15 improves risk stratification in unselected patients with acute chest pain and provides prognostic information beyond clinical characteristics, the ECG, and cTnI." 10/01/2008 - "We explored the usefulness of GDF-15 for early risk stratification in 479 unselected patients with acute chest pain. " 02/01/2012 - "In a prospective, international multicenter study, GDF-15, high-sensitivity cardiac troponin T (hs-cTnT), and B-type natriuretic peptide (BNP) were measured in 646 unselected patients presenting to the emergency department with acute chest pain. " 01/01/2015 - "We determined whether placenta derived growth factor (PlGF), soluble Fms-like tyrosine kinase 1 (sFlt-1), myoglobin, N-terminal prohormone B-type Natriuretic Peptide (NT-proBNP), growth-differentiation factor 15 (GDF-15) and copeptin improved early assessment of chest pain patients. "
5.	Mitochondrial Diseases (Mitochondrial Disease) 11/01/2015 - "Our results suggest that measurement of GDF-15 is the most useful first-line test to indicate the patients who have the mitochondrial respiratory chain deficiency. " 11/01/2015 - "Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders." 01/01/2015 - "We found that expression and secretion of growth differentiation factor 15 (GDF15) were increased in 2SD cells treated with lactate and that serum GDF15 levels were significantly higher in patients with mitochondrial diseases than in those with other diseases, suggesting that GDF15 could be a useful marker for diagnosis and evaluating the therapeutic efficacy of pyruvate."

Related Drugs and Biologics

1.	hepcidin
2.	pro-brain natriuretic peptide (1-76)
3.	Brain Natriuretic Peptide (Natrecor)
4.	Lactic Acid
5.	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)
6.	Leptin
7.	Pyruvic Acid (Pyruvate)
8.	Myoglobin
9.	Insulin (Novolin)
10.	Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1.	Chemoprevention
2.	Gastric Bypass (Roux-en-Y Gastric Bypass)
3.	Splenectomy
4.	Drug Therapy (Chemotherapy)
5.	Bariatric Surgery