Myostatin

01/01/2009 - "Further studies of myostatin inhibition as a treatment for muscular dystrophy are warranted, and single muscle fiber contractile studies are a useful assay for muscle function at the cellular level."
02/15/2005 - "Previous studies in the mdx mouse model of muscular dystrophy demonstrate that inhibiting myostatin attenuates several features of dystrophic muscle. "
01/01/2015 - "Evaluation of Electrical Impedance as a Biomarker of Myostatin Inhibition in Wild Type and Muscular Dystrophy Mice."
01/01/2014 - "Our results suggest, not only a novel in vivo pharmacological treatment directed specifically at activating the satellite cells, but also a myostatin dependent mechanism that may contribute to the progressive muscle wasting seen in severely affected patients with muscular dystrophy and significant on-going regeneration. "
01/01/2013 - "Strategies to block myostatin signaling pathway have been extensively pursued to increase muscle mass in various disease settings including muscular dystrophy. "

01/30/2015 - "Recent studies demonstrated an association between the K153R polymorphism in the myostatin gene with extreme longevity, lower muscle strength and obesity but the molecular basis of these associations has not been clarified. "
01/01/2014 - "This study evaluated gene and protein expression of myostatin and its receptor, ActRIIB in adipose tissues and skeletal muscles and serum myostatin concentrations in six lean and six obese animals to explore putative associations between these factors and obesity in horses and ponies. "
10/01/2013 - "Ongoing studies will determine whether pharmacologic therapy such as myostatin inhibitors or GHRH analogs have a role in the treatment of sarcopenic obesity."
08/01/2012 - "In addition, lack of data regarding muscle mass is another limitation in this study that prevents clarification of the relationship between myostatin, lean mass and obesity and therefore restricts the clinical application of the results. "
02/25/2012 - "To study the association of myostatin gene polymorphisms with obesity in Chinese north Han human subjects. "

10/01/2014 - "Myostatin inhibition: a new treatment for androgen deprivation-induced sarcopenia?"
08/01/2007 - "The present study specifically tests the therapeutic value of a myostatin antagonist in sarcopenia. "
12/01/2015 - "Higher serum myostatin independently associated with higher odds for sarcopenia in men (OR = 1.11, 95 % CI 1.00-1.24, p = 0.041). "
12/01/2015 - "Myostatin inhibition for treatment of sarcopenia."
08/01/2015 - "One of the genetic contributors to sarcopenia predisposition is Myostatin (MSTN), which in humans encodes myostatin, a 376 amino acid growth factor protein that negatively regulates muscle growth. "

09/01/2015 - "Deletion of the myostatin gene (Mstn) in mice leads to muscle hypertrophy, and animal studies support the concept that myostatin is a negative regulator of muscle growth and regeneration. "
01/01/2012 - "Fundamental study of detection of muscle hypertrophy-oriented gene doping by myostatin knock down using RNA interference."
07/01/2011 - "The objective of this study was to estimate genetic effects for the muscle hypertrophy mutation (mh) of the myostatin gene for conventional milk production traits and for milk fatty acid composition in dual-purpose Belgian Blue dairy cows. "
09/01/2015 - "Myostatin (mstn) blockade, resulting in muscle hypertrophy, is a promising therapy to counteract age-related muscle loss. "
08/01/2015 - "Myostatin dysfunction promotes muscle hypertrophy, which can complicate assessment of muscle properties. "

01/01/2013 - "Complementary studies examined APS effects on the saturated acid palmitate-induced insulin resistance and myostatin expression in C2C12 cells. "
01/01/2012 - "Recent animal studies suggest a role for myostatin in insulin resistance. "
11/01/2010 - "Despite these intriguing findings, there have been few studies linking myostatin and insulin resistance. "
07/25/2014 - "Reply to Rodgers: does myostatin induce insulin resistance?"
07/25/2014 - "Does myostatin induce insulin resistance?"