Myostatin

09/01/2009 - "Thus, myostatin deletion does not affect aging-related increases in cardiac mass and appears beneficial for bone density, insulin sensitivity and heart function in senescent mice. "
01/01/2023 - "Animal studies have demonstrated that deficiency in myostatin promotes muscle growth and protects against insulin resistance. "
05/23/2017 - "In this study, we investigated if the inhibition of porcine myostatin has any effect on fat deposition and insulin sensitivity using genetically engineered Meishan pigs containing a myostatin loss-of-function mutation (Mstn -/- ). "
01/01/2012 - "Recent animal studies suggest a role for myostatin in insulin resistance. "
06/01/2011 - "Therefore, the aim of the current study was to identify signalling pathways through which myostatin regulates insulin sensitivity. "

12/01/2021 - "Efficacy of passive repetitive stretching of skeletal muscle on myofiber hypertrophy and genetic suppression on MAFbx, MuRF1, and myostatin."
09/01/2015 - "Deletion of the myostatin gene (Mstn) in mice leads to muscle hypertrophy, and animal studies support the concept that myostatin is a negative regulator of muscle growth and regeneration. "
01/01/2012 - "Fundamental study of detection of muscle hypertrophy-oriented gene doping by myostatin knock down using RNA interference."
03/01/2023 - "Exploratory analyses revealed upregulation of mRNAs for muscle hypertrophy markers [IRS-1, Akt, mTOR] and downregulation of protein degradation markers [myostatin, MurF-1, and PDK4] in the high-responders compared to low-responders. "
11/20/2022 - "In addition to pharmacological agents, some supplements and nutraceutical agents have demonstrated modulatory effects on myostatin levels; however, the clinical magnitude must be appraised with skepticism before translating the mechanistic effects into muscle hypertrophy outcomes. "

10/01/2020 - "Recent terminations of clinical trials of myostatin inhibitors in muscular dystrophy have raised questions about the predictiveness of mouse models for this therapeutic strategy. "
01/01/2009 - "Further studies of myostatin inhibition as a treatment for muscular dystrophy are warranted, and single muscle fiber contractile studies are a useful assay for muscle function at the cellular level."
02/15/2005 - "Previous studies in the mdx mouse model of muscular dystrophy demonstrate that inhibiting myostatin attenuates several features of dystrophic muscle. "
07/26/2023 - "Myostatin, an important negative regulator of muscle mass, is a therapeutic target for muscle atrophic disorders such as muscular dystrophy. "
02/22/2023 - "Inhibition of myostatin is an attractive strategy for the treatment of muscular atrophic diseases such as muscular dystrophy. "

03/01/2019 - "Myostatin inhibition shown to improve sarcopenia in elderly, frail patients; further study needed in ESLD patients. "
01/01/2022 - "Herein, we analyzed the association between serum myostatin and IS levels and sarcopenia in patients with CKD, by performing a post hoc analysis of baseline data extracted from the RECOVERY study (clinicaltrials.gov: NCT03788252) of 150 patients with CKD. "
01/01/2022 - "Role of Myostatin in Muscle Degeneration by Random Positioning Machine Exposure: An in vitro Study for the Treatment of Sarcopenia."
10/01/2021 - "The purpose of this study was to examine the role of skeletal muscle myostatin in sarcopenia. "
01/01/2021 - "Decreased irisin levels seem to be potentially associated to sarcopenia, whereas increased myostatin has shown to negatively impact on sarcopenia in pre-clinical studies. "

01/01/2018 - "However, studies also revealed potential downsides of myostatin targeting in skeletal muscle and other tissues, which raises the question if myostatin is indeed a valuable target to counteract muscle atrophy. "
01/01/2018 - "Since then, a wealth of studies have uncovered the potential involvement of myostatin in muscle atrophy and sparked interest in myostatin as a promising therapeutic target to counteract decline of muscle mass in patients afflicted with different muscle-wasting conditions. "
04/01/2014 - "The purpose of our study was to compare two acquired muscle atrophies and the use of myostatin inhibition for their treatment. "
08/01/2013 - "Although further studies are necessary, the therapeutic inhibition of myostatin may help prevent the muscle atrophy that occurs after ACL reconstruction and provide an accelerated return of patients to sport."
07/01/2007 - "To conclude, our study demonstrates that myostatin-induced muscle atrophy elicits the down-regulation of muscle-specific gene expression. "