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Bone Morphogenetic Protein 15

A protein that plays a role in GRANULOSA CELLS where it regulates folliculogenesis. Mutations in the gene for bone morphogenetic protein 15 are linked to reproductive abnormalities such as PREMATURE OVARIAN FAILURE.
Also Known As:
BMP-15; GDF-9 Related Factor; GDF-9-Related Protein; GDF-9B; Growth Differentiation Factor 9B; GDF 9 Related Factor; GDF 9 Related Protein
Networked: 44 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Shimasaki, Shunichi: 4 articles (06/2008 - 04/2005)
2. Cao, Yunxia: 3 articles (02/2018 - 01/2010)
3. Wang, Binbin: 3 articles (02/2018 - 01/2010)
4. Wang, Jing: 3 articles (02/2018 - 01/2010)
5. Fang, Cong: 3 articles (10/2013 - 08/2011)
6. Andersen, Claus Yding: 2 articles (01/2022 - 07/2018)
7. Ernst, Erik: 2 articles (01/2022 - 07/2018)
8. Macklon, Kirsten Tryde: 2 articles (01/2022 - 07/2018)
9. Mamsen, Linn Salto: 2 articles (01/2022 - 07/2018)
10. Chen, Zi-Jiang: 2 articles (11/2015 - 01/2007)

Related Diseases

1. Sarcoma (Soft Tissue Sarcoma)
2. Infertility (Sterility)
11/01/2011 - "A new mutation in the bone morphogenetic protein 15 (BMP15) gene (FecX(R) allele) causing increased prolificacy in heterozygous (R+) and sterility in homozygous ewes has been recently described in Rasa Aragonesa, a low-prolificacy Mediterranean breed. "
06/01/2008 - "A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep."
12/01/2006 - "In contrast to these monoovulatory mammals, the targeted deletion of BMP-15 in polyovulatory mice results in subfertility with only minimal defects in the ovulation process. "
04/29/2005 - "The in vivo relevance of the role of BMP-15 was established by the identification of naturally occurring BMP-15 mutations in sheep, which cause infertility in homozygous carrier ewes and, in striking contrast, increased fecundity in heterozygous carrier ewes due to an increase in ovulation quota. "
12/05/2017 - "The cells in the control group were cultured with complete medium of DMEM/F-12, an extra of FSH at a dose of 12 μg/L was added in the FSH group, an extra of BMP-15 at a dose of 6 μg/L was added to the BMP-15 group, an extra of 5% of the follicular fluid from the patients with tubal or male factor infertility was added to the tubal group, an extra of 5% of the follicular fluid from the patients with endometriosis infertility was added to the endometriosis group, an extra of 5% of the follicular fluid from the patients with endometriosis infertility plus FSH at a dose of 12 μg/L were added to the endometriosis plus FSH group, and an extra of 5% of the follicular fluid from the patients with endometriosis infertility plus BMP-15 at a dose of 6 μg/L were added to the endometriosis plus BMP-15 group. "
3. Ovarian Hyperstimulation Syndrome
4. Breast Neoplasms (Breast Cancer)
5. Varicocele

Related Drugs and Biologics

1. Growth Differentiation Factor 9
2. Reactive Oxygen Species (Oxygen Radicals)
3. Catalase
4. Cyclin-Dependent Kinase 2
5. superoxide dismutase 2
6. Proteins (Proteins, Gene)
7. Factor IX (Coagulation Factor IX)
8. Basic Helix-Loop-Helix Transcription Factors
9. Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
10. Progesterone Receptors (Progesterone Receptor)