Bone Morphogenetic Protein 7

04/01/2002 - "Treatment with BMP-7 eliminated peritrabecular fibrosis, increased osteoblast number, osteoblast surface, mineralizing surface and single labeled surface. "
05/01/2014 - "The aim of the present study was to explore any possible association between fibrosis levels (as revealed by liver biopsy) and serum BMP-7 levels. "
01/01/2013 - "In this study, we aim to investigate the potential effect of BMP-7 on hepatic fibrosis in rats. "
05/01/2009 - "Recent studies indicate that BMP-7 could reverse established renal fibrosis in mice, primarily through counteracting TGF-beta1-mediated EMT. "
02/23/2005 - "Animal studies are very encouraging, as exogenous BMP-7 has allowed stabilisation and even regression of renal fibrosis with a concomitant stabilisation or improvement of renal function. "

03/01/2013 - "BMP-7 signaling pathway activation was shown by the presence of phosphorylation of Smad1/5/8. Utilizing the reactivity of polydopamine films to immobilize BMP-7 peptide onto metal substrates may provide a promising approach for applications in situations where reduction of inflammation around implants would be beneficial in improving surgical outcome, bone healing, and implant integration."
01/01/2002 - "Taken together, these observations suggest that BMP-7 may be a novel therapeutic agent for kidney disorders involving inflammation and ischemic damage of PTEC."
08/01/2003 - "Previous studies have shown an abundant expression of BMP-7 in the developing intestine and an association with a perturbed BMP/SMAD downstream signaling leading to a malignant phenotype and inflammation in the gut. "
01/01/2014 - "Anabolic cartilage-specific BMP-7 with highly significant intra-articular levels was significantly elevated in vitro on day 10 following maximum inflammation. "
01/01/2014 - "These results suggest a protective role for BMP-7 in lung allergic inflammation, opposing the pro-fibrotic effects of TGF- β1. "

12/01/2015 - "Therefore, further investigations are needed to confirm the exact role of BMP-7 in progressive chronic kidney disease. "
05/01/2015 - "Cell type specific changes in BMP-7 expression contribute to the progression of kidney disease in patients with obstructive uropathy."
01/01/2015 - "BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic Kidney Disease."
01/01/2015 - "A large variety of evidence shows an anti-fibrotic role of BMP-7 in chronic kidney disease, and this effect is largely mediated via counterbalancing the profibrotic effect of TGF-β. "
01/01/2012 - "Bone morphogenetic protein 7 (BMP7) has been suggested to play a protective role against kidney injury in chronic kidney disease. "

01/01/2010 - "By week 12, most participants in both the BMP-7 and placebo groups experienced a 20% improvement in pain and overall the BMP-7 group was similar to placebo with regard to this measurement. "
09/01/2005 - "To study the therapeutic efficacy of intradiscal injection of osteogenic protein-1 (OP-1) to reduce degeneration and associated discogenic pain. "
01/01/2010 - "The 1 mg BMP-7 group showed a higher frequency of injection site pain and there was no ectopic bone formation seen on plain x-rays. "
01/01/2010 - "The patient achieved self-mobility with full weight bearing and absence of pain 10 months after adjuvant implantation of BMP-7."
06/04/2004 - "In contrast to other intraventricularly administered neurotrophic factors, BMP-7 was not associated with an increase in the sensitivity to pain. "

02/01/2005 - "Beside the protective effects, BMP-7 given after stroke improves locomotor function. "
02/01/2003 - "Our data indicate that BMP-7, given parenterally after stroke, can pass through the blood-brain barrier on the ischemic side and induce behavioral recovery in stroke animals at longer testing times."
01/01/2001 - "In addition, expression of BMP-7, which has been recently demonstrated to improve the motor neuron recovery from stroke, was induced by UC while it was not detected in untreated cells. "
03/03/2000 - "Time window of intracisternal osteogenic protein-1 in enhancing functional recovery after stroke."
05/11/1998 - "Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke."