Bone Morphogenetic Protein 6

A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.

Also Known As:

Networked: 96 relevant articles (0 outcomes, 15 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yang, Shuang: 9 articles (12/2013 - 09/2003)
2.	Zhang, Jie: 7 articles (06/2011 - 09/2003)
3.	Zhu, Tianhui: 6 articles (12/2013 - 01/2007)
4.	Kim, Isaac Yi: 5 articles (02/2014 - 12/2003)
5.	Lee, Geun Taek: 5 articles (02/2014 - 09/2009)
6.	Du, Jun: 5 articles (04/2009 - 01/2007)
7.	Yuan, Wei: 5 articles (04/2009 - 01/2007)
8.	Kwon, Seok Joo: 4 articles (02/2014 - 09/2009)
9.	Kim, Wun-Jae: 4 articles (02/2014 - 10/2011)
10.	Zhang, Ming: 4 articles (02/2011 - 10/2005)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2014 - "Bone morphogenetic protein 6 (BMP6) is an important regulator of cell growth, differentiation and apoptosis in various types of tumor. " 02/01/2014 - "In vivo, tumor growth and neovascularization decreased significantly when BMP-6 was expressed in IL-1a knockout and conditional macrophage-null mice. " 12/01/2013 - "Increased expression of BMP-6 in oral cavity cancer may affect bone invasion." 12/01/2013 - "In addition, increased BMP-6 expression correlated with aggressive behavior in the smaller tumors. " 12/01/2013 - "Expression of BMP-6 was significantly higher in the T2 /4 cohort (tumor less than 4 cm with bony invasion) than the larger tumors without bone invasion (T4 /4 cohort, P = .05). "
2.	Neoplasm Metastasis (Metastasis) 10/01/1997 - "The results suggest a close association between BMP-6 expression in primary malignant prostatic tissue and skeletal metastases. " 01/01/2007 - "Recent studies indicate that BMP-6 is closely related to tumor differentiation and metastasis. " 03/01/2001 - "Furthermore, a study of clinical cases of benign and malignant prostate lesion by in situ hybridization showed that BMP-6 expression was high at both primary and secondary sites in cases of advanced cancer with metastasis. " 03/18/2014 - "Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction." 06/01/2011 - "Our recent research has implied that BMP-6 may suppress breast cancer metastasis. "
3.	Breast Neoplasms (Breast Cancer) 03/01/2014 - "[Expression and clinical significance of bone morphogenetic protein 6 in human breast cancer]." 12/01/2013 - "BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer." 04/01/2009 - "A reverse correlation between BMP-6 and miR-21 was also determined in breast cancer tissue samples. " 04/01/2009 - "We initiated experiments to identify the relationships between miR-21 and BMP-6 in breast cancer progression. " 04/01/2008 - "Bone morphogenetic protein 6 inhibit stress-induced breast cancer cells apoptosis via both Smad and p38 pathways."
4.	Adenocarcinoma 01/01/1995 - "BMP-6 was detected in both rat normal prostate and in Dunning rat-prostate adenocarcinoma sublines. " 12/01/1992 - "BMP-6 expression was detected in the prostate tissue of over 50% of patients with clinically defined metastatic prostate adenocarcinoma, but was not detected in non-metastatic or benign prostate samples or in ocular melanoma tissue. " 11/01/1998 - "This study examines the expression of BMP-6 mRNA in matched prostatic primary and secondary bony lesions and in isolated skeletal metastases from prostatic adenocarcinomas, as well as other common human malignancies, by in situ hybridization. " 11/01/1998 - "BMP-6 mRNA appears to be strongly expressed in prostatic adenocarcinomas, both in the primary tumour and in bone metastases. " 11/01/2001 - "Bone sialoprotein, bone morphogenetic protein 6 and thymidine phosphorylase expression in localized human prostatic adenocarcinoma as predictors of clinical outcome: a clinicopathological and immunohistochemical study of 43 cases."
5.	Osteosarcoma (Osteogenic Sarcoma) 08/21/2003 - "Mesenchymal cells of murine (osteoblastic MC3T3-E1 cells, preadipogenic ST2 cells, prechondrogenic ATDC5 cell) and human origin (osteosarcoma SaOS and HOS cells, primary bone marrow stromal cells) were cultured in the presence of recombinant BMP-6 under serum-free conditions. " 05/01/2002 - "High expression of BMP-6 was found in those parts of the osteosarcoma with a chondroid differentiation (p = 0.016, Mann-Whitney test). " 03/01/2004 - "In further studies where we compared the intracellular distribution of ERalpha associated with these responses, E2-dependent stimulation of the BMP-6 reporter in MCF-7 cells was associated with intranuclear localization of ERalpha, whereas extranuclear localization was seen in rat osteosarcoma cells (ROS) cells treated with ICI. " 03/01/1997 - "Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Iron
3.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
4.	hepcidin
5.	Cadherins (E-Cadherin)
6.	Estrogen Receptor alpha
7.	Integrin-Binding Sialoprotein
8.	Thymidine Phosphorylase
9.	Ligands
10.	Bone Morphogenetic Protein 7

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Nephrectomy
4.	Castration