Growth Differentiation Factor 10

A growth differentiation factor that is closely-related in structure to BONE MORPHOGENETIC PROTEIN 3. Growth differentiation factor 10 is found at high levels in BONE, however it plays an additional roles in regulating EMBRYONIC DEVELOPMENT.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hino, J: 2 articles (01/2017 - 05/2012)
2.	Kangawa, K: 2 articles (01/2017 - 05/2012)
3.	Miyazato, M: 2 articles (01/2017 - 05/2012)
4.	Baptista, Daniela: 1 article (02/2022)
5.	Brandt, Karim J: 1 article (02/2022)
6.	Burger, Fabienne: 1 article (02/2022)
7.	Fernandes da Silva, Rafaela: 1 article (02/2022)
8.	Mach, Francois: 1 article (02/2022)
9.	Miteva, Kapka: 1 article (02/2022)
10.	Montecucco, Fabrizio: 1 article (02/2022)

Related Diseases

1.	Intellectual Disability (Idiocy) 01/01/2018 - "In the present study, we aimed to describe the effects of BMP-3b gene depletion on neonatal hypoxic-ischemic encephalopathy, which frequently results in death or lifelong neurological disabilities, such as cerebral palsy and mental retardation. " 10/01/2019 - "In addition, factors related to axonal sprouting, including growth‑associated protein 43 (GAP43), postsynaptic density protein 95, synaptophysin, α‑thalassemia/mental retardation syndrome X‑linked homolog (ATRX), growth differentiation factor 10 (GDF10), and leucine‑rich repeat and immunoglobulin domain‑containing 1, were measured by western blot analyses. "
2.	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/01/2018 - "In the present study, we aimed to describe the effects of BMP-3b gene depletion on neonatal hypoxic-ischemic encephalopathy, which frequently results in death or lifelong neurological disabilities, such as cerebral palsy and mental retardation. "
3.	Lung Neoplasms (Lung Cancer) 06/18/2012 - "Our studies identified BMP-3B as a new Runx2 target gene and revealed a novel function of Runx2 in silencing of BMP-3B in lung cancers. " 06/18/2012 - "Here we show that Runx2 is highly expressed in lung cancer cells and downregulates BMP-3B. " 06/18/2012 - "The ectopic expression of Runx2, but not DNA binding mutant Runx2, in normal lung fibroblast cells and lung cancer cells resulted in suppression of BMP-3B levels. "
4.	Cerebral Palsy (Spastic Diplegia) 01/01/2018 - "In the present study, we aimed to describe the effects of BMP-3b gene depletion on neonatal hypoxic-ischemic encephalopathy, which frequently results in death or lifelong neurological disabilities, such as cerebral palsy and mental retardation. "
5.	Obesity 01/01/2017 - "These results provide in vivo evidence that BMP-3b regulates adipocyte function to cause an anti-obesity effect." 01/01/2017 - "We examined BMP-3b Tg mice fed a high-fat diet to elucidate the effects of BMP-3b on obesity. " 05/01/2012 - "In mesenteric adipose tissue, BMP-3b expression was increased in diet-induced obesity (DIO) mice as compared with that in control mice. " 01/01/2017 - "We previously found that BMP-3b is highly expressed in adipocytes, its level is increased during obesity, and it inhibits adipogenesis by suppressing peroxisome proliferator-activated receptor γ (PPARγ) in vitro. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Peroxisome Proliferator-Activated Receptors (PPAR)
3.	Synaptophysin
4.	Cytokines
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Immunoglobulins (Immunoglobulin)
7.	DNA (Deoxyribonucleic Acid)
8.	Disks Large Homolog 4 Protein