Ventilator-Induced Lung Injury

Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.

Also Known As:

Networked: 532 relevant articles (38 outcomes, 57 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation
2.	Lung Injury
3.	Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
4.	Hypercapnia
5.	Wounds and Injuries (Trauma)

Experts

1.	Slutsky, Arthur S: 21 articles (12/2015 - 12/2002)
2.	Birukov, Konstantin G: 17 articles (12/2015 - 05/2006)
3.	Birukova, Anna A: 17 articles (12/2015 - 05/2006)
4.	Schultz, Marcus J: 17 articles (09/2015 - 07/2008)
5.	Zhang, Haibo: 16 articles (12/2014 - 12/2002)
6.	Garcia, Joe G N: 12 articles (12/2015 - 08/2005)
7.	Fu, Panfeng: 10 articles (12/2015 - 01/2008)
8.	Gatto, Louis A: 10 articles (12/2015 - 06/2003)
9.	Juffermans, Nicole P: 10 articles (01/2013 - 07/2008)
10.	Nieman, Gary F: 9 articles (12/2015 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ventilator-Induced Lung Injury:

1.	oxidized- L- alpha- 1- palmitoyl- 2- arachidonoyl- sn- glycero- 3- phosphorylcholineIBA 08/01/2011 - "Inhibition of Rap1 function suppressed OxPAPC-mediated pulmonary EC barrier enhancement and AJ and TJ interactions in vitro, as well as inhibited protective effects of OxPAPC against ventilator-induced lung injury in vivo. " 01/01/2008 - "OxPAPC exhibits protective effects in these models of ventilator-induced lung injury." 01/01/2008 - "To test the hypothesis that OxPAPC may attenuate lung inflammation and barrier disruption caused by pathologic lung distension, we used a rodent model of ventilator-induced lung injury and an in vitro model of pulmonary endothelial cells exposed to pathologic mechanochemical stimulation. " 05/01/2012 - "Afadin knockdown also abolished protective effects of OxPAPC against ventilator-induced lung injury in vivo. " 04/01/2011 - "This study tested the hypothesis that Rho negative regulator p190RhoGAP is essential for OxPAPC-induced lung barrier protection against ventilator-induced lung injury (VILI), and investigated potential mechanism of p190RhoGAP targeting to adherens junctions (AJ) via p120-catenin. "
2.	OxygenIBA 09/01/2000 - "Whether these changes translate into improved clinical outcomes has yet to be determined, but prone ventilation has the potential of reducing oxygen toxicity and limiting ventilator-induced lung injury." 01/01/2010 - "The Calu-3 cell preparation is a sensitive and efficient preclinical model to study human respiratory processes and diseases related to oxygen- and ventilator-induced lung injury." 02/01/2009 - "We conducted this study to evaluate the effect of a high inspired oxygen concentration on ventilator-induced lung injury. " 11/01/2010 - "We hypothesized that reducing mPaw and FiO(2) too quickly after reaching target arterial oxygen saturation levels would promote ventilator induced lung injury (VILI). " 02/01/2009 - "These findings suggest that short-term administration of a high oxygen concentration is not a major determinant of ventilator-induced lung injury in this experimental model."
3.	HydrogenIBA 05/06/2011 - "We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. " 01/01/2010 - "Hydrogen inhalation ameliorates ventilator-induced lung injury." 05/06/2011 - "Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation."
4.	Heme Oxygenase-1IBA 07/01/2010 - "[A study of the role of heme oxygenase-1 expression in ventilator induced lung injury and its mechanism in rats]." 02/29/2012 - "Heme oxygenase-1 system, inflammation and ventilator-induced lung injury." 07/01/2015 - "[Research on the effect of protection against ventilator-induced lung injury via regulation of caveolin-1/heme oxygenase-1 signaling]." 12/01/2015 - "Long-term administration of simvastatin reduces ventilator-induced lung injury and upregulates heme oxygenase 1 expression in a rat model." 07/01/2010 - "To observe the changes in heme oxygenase-1 (HO-1) expression in lung tissue with ventilator induced lung injury (VILI) in rats, and to explore the mechanism of preventive effect of HO-1 inducer hemin on VILI. "
5.	DexmedetomidineFDA Link 03/01/2014 - "Dexmedetomidine regulates inflammatory molecules contributing to ventilator-induced lung injury in dogs." 06/01/2011 - "[Effects of dexmedetomidine hydrochloride on ERK1/2 activation in a rat model of ventilator-induced lung injury]." 03/01/2014 - "The aim of this study was to clarify the effect of dexmedetomidine-regulating inflammation on a noninfectious, ventilator-induced lung injury (VILI) in dogs. " 06/01/2011 - "To investigate the effect of dexmedetomidine hydrochloride on inflammatory lung injury and phosphorylation of extracellular regulated protein (ERK1/2) in a rat model of ventilator-induced lung injury (VILI). " 12/01/2008 - "We sought to elucidate the effects of dexmedetomidine, a selective alpha2-adrenergic receptor agonist, on the regulation of pulmonary inflammation in ventilator-induced lung injury (VILI) in a rat model. "
6.	delta cateninIBA 01/01/2015 - "Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury." 08/01/2011 - "Our findings demonstrate that p120-catenin plays a critical protective role in cyclic stretch-induced alveolar barrier dysfunction, and, thus, maintenance of p120-catenin expression may be a novel therapeutic strategy for the prevention and treatment of ventilator-induced lung injury." 04/01/2011 - "This study tested the hypothesis that Rho negative regulator p190RhoGAP is essential for OxPAPC-induced lung barrier protection against ventilator-induced lung injury (VILI), and investigated potential mechanism of p190RhoGAP targeting to adherens junctions (AJ) via p120-catenin. "
7.	sevoflurane (Ultane)FDA LinkGeneric 02/01/2015 - "The volatile anesthetic sevoflurane attenuates ventilator-induced lung injury through inhibition of ERK1/2 and Akt signal transduction." 01/01/2013 - "This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice. " 01/01/2013 - "Sevoflurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice."
8.	GABA Receptors (GABA Receptor)IBA 01/01/2012 - "GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance." 01/01/2012 - "The present study investigated the role of GABA receptors in ventilator-induced lung injury. "
9.	Amifostine (Ethyol)FDA LinkGeneric 12/01/2011 - "Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury." 12/01/2011 - "This study tested effects of chronic amifostine administration on parameters of oxidative stress, lung barrier function, and inflammation associated with ventilator-induced lung injury. " 12/01/2011 - "Amifostine preconditioning activates lung tissue antioxidant cell defense mechanisms and may be a promising strategy for alleviation of ventilator-induced lung injury in critically ill patients subjected to extended mechanical ventilation." 12/01/2011 - "To test the hypothesis that preconditioning animals with amifostine improves ventilator-induced lung injury via induction of antioxidant defense enzymes. " 12/01/2011 - "Mice received once-daily dosing with amifostine (10-100 mg/kg, intraperitoneal injection) 3 days consecutively before high tidal volume ventilation (30 mL/kg, 4 hrs) at day 4. Pulmonary endothelial cell cultures were exposed to pathologic cyclic stretching (18% equibiaxial stretch) and thrombin in a previously verified two-hit model of in vitro ventilator-induced lung injury. "
10.	saikosaponinIBA 01/01/2015 - "The current study aimed to investigate the protective effects of saikosaponin-d on ventilator-induced lung injury (VILI) in rats. " 01/01/2015 - "Collectively, our study demonstrated that saikosaponin-d may attenuate ventilator induced lung injury through inhibition of inflammatory responses, oxidative stress and apoptosis. " 01/01/2015 - "Saikosaponin-d attenuates ventilator-induced lung injury in rats."

Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation) 11/01/2012 - "This improved prognosis is also due to the advent of protective mechanical ventilation that has limited ventilator-induced lung injury (VILI). " 07/01/2006 - "The improvement in survival in premature infants associated with the evolution of mechanical ventilation has been accompanied by an increase in ventilator induced lung injury. " 01/01/2004 - "Prevention of ventilator-induced lung injury while accomplishing the essential life-supporting roles of mechanical ventilation is a complex undertaking that requires application of principles founded on a broad experimental and clinical database and on the results of well-executed clinical trials. " 10/01/2003 - "Future randomized trials will need to consider the potential effects of OP on pulmonary mechanics and potential influences on the known risks of ventilator-induced lung injury associated with mechanical ventilation." 09/01/1996 - "This study demonstrated that moderate alveolar hyperdistention caused significant structural lung damage accompanied by decreased ACE activity after seven hours of mechanical ventilation and that elevated lung lavage and serum LDH and AST levels in lung lavage and in serum might be early markers of ventilator-induced lung injury in this rat model."
2.	Positive-Pressure Respiration (PEEP) 06/15/2003 - "This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation." 06/01/2009 - "Previous experimental studies of ventilator-induced lung injury have shown that positive end-expiratory pressure (PEEP) is protective. " 01/01/2009 - "Despite experimental evidence that higher levels of PEEP protect against ventilator-induced lung injury, recent clinical trials have failed to demonstrate clear survival benefits. " 07/01/2003 - "Many studies have investigated the protective role of positive end-expiratory pressure (PEEP) on ventilator-induced lung injury. " 12/01/2015 - "High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. "
3.	Critical Care 01/01/2010 - "In a study reported in this issue of Critical Care, Maniatis and colleagues show that pretreatment of mice with inhaled APC is protective against ventilator-induced lung injury. " 02/01/2012 - "Ventilator-induced lung injury (VILI) is a ubiquitous iatrogenic clinical problem in critical care. " 07/01/2002 - "The pulmonary physician in critical care * 7: ventilator induced lung injury." 06/01/2008 - "Mechanical ventilation during critical care can cause structural and functional disturbances in the lung with subsequent release of proinflammatory mediators, termed ventilator-induced lung injury (VILI). " 12/01/2011 - "Pulmonary issues in acute and critical care: pulmonary embolism and ventilator-induced lung injury."
4.	Mechanical Ventilators (Ventilator) 02/01/2016 - "Recent clinical studies suggest that adjusting ventilator settings based on transpulmonary pressure measurements is feasible, may improve oxygenation, and reduce ventilator-induced lung injury. " 10/01/2011 - "No single mode has consistently demonstrated superiority in clinical trials; however, empiric management with a pressure mode may achieve the goals of patient-ventilator synchrony, effective respiratory system support, adequate gas exchange, and limited ventilator-induced lung injury." 02/01/2015 - "Ventilator-induced lung injury (VILI) sustained during mechanical ventilator support is still a cause of a high rate of morbidity and mortality in intensive care units and in operating rooms. " 02/01/2015 - "The present article summarizes the background and clinical evidence for ventilator settings that have the potential to protect against ventilator-induced lung injury. " 11/01/2012 - "This article reviews the pathophysiology of ARDS and ventilator-induced lung injury and presents current evidence-based strategies for ventilator settings in ARDS."
5.	Extracorporeal Membrane Oxygenation (ECMO) 02/01/2016 - "The only proven beneficial therapeutic options in ARDS are those that help to prevent further ventilator-induced lung injury, such as prone position, use of lung-protective ventilation strategies, and extracorporeal membrane oxygenation. " 12/01/2015 - "Therefore, the risks of causing ventilator-induced lung injury are of foremost importance; however, the issue of the optimum ventilatory strategy during VV-ECMO has not received sufficient consideration. " 01/01/2015 - "Venovenous extracorporeal membranous oxygenation (VV-ECMO) is an emerging tool to avoid ventilator-induced lung injury. " 06/01/2013 - "Once the decision is made to cannulate a patient for ECMO, meticulous multi-organ-system management is required, with a priority being placed on lung rest and minimization of ventilator-induced lung injury. " 05/01/2013 - "ECMO provides support that prevents ventilator-induced lung injury while the lungs heal. "