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AMP-Activated Protein Kinases

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Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.

Also Known As:

5'-AMP-Activated Protein Kinase; AMP-Activated Kinase; AMP-Activated Protein Kinase; AMP-Activated Protein Kinase alpha Subunit; AMP-Activated Protein Kinase alpha Subunits; AMP-Activated Protein Kinase beta Subunit; AMP-Activated Protein Kinase beta Subunits; AMP-Activated Protein Kinase gamma Subunit; AMP-Activated Protein Kinase gamma Subunits; 5' AMP Activated Protein Kinase; AMP Activated Kinase; AMP Activated Protein Kinase; AMP Activated Protein Kinase alpha Subunit; AMP Activated Protein Kinase alpha Subunits; AMP Activated Protein Kinase beta Subunit; AMP Activated Protein Kinase beta Subunits; AMP Activated Protein Kinase gamma Subunit; AMP Activated Protein Kinase gamma Subunits; AMP Activated Protein Kinases

Networked: 1076 relevant articles (30 outcomes, 100 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Viollet, Benoit: 27 articles (01/2016 - 07/2004)
2.	Hardie, D Grahame: 25 articles (01/2014 - 06/2002)
3.	Ha, Joohun: 19 articles (04/2014 - 10/2003)
4.	Kang, Insug: 13 articles (04/2014 - 10/2003)
5.	Dyck, Jason R B: 12 articles (10/2015 - 07/2004)
6.	Carling, David: 12 articles (04/2015 - 01/2002)
7.	Bertrand, Luc: 12 articles (01/2014 - 08/2002)
8.	Steinberg, Gregory R: 11 articles (07/2015 - 05/2006)
9.	Kim, Sung-Soo: 11 articles (02/2014 - 10/2003)
10.	Hwang, Jin-Taek: 11 articles (07/2011 - 10/2003)

Related Diseases

1.	Insulin Resistance 10/15/2014 - "AMP-activated protein kinase (AMPK) has been studied extensively and postulated to be a target for the treatment and/or prevention of metabolic disorders such as insulin resistance. " 07/15/2014 - "In both rodents and humans, aging-associated reductions in skeletal muscle AMP-activated protein kinase (AMPK) activity and mitochondrial function have been linked to the development of skeletal muscle insulin resistance. " 04/25/2014 - "[Progress on relationship between exercise improving insulin resistance and AMP-activated protein kinase]." 07/01/2013 - "The effect of LMWF-mediated AMP-activated protein kinase (AMPK) activation on insulin resistance via regulation of the ER stress-dependent pathway was examined in vitro and in vivo. " 06/01/2013 - "Activation of AMP-activated protein kinase (AMPK) signaling reduces hepatic steatosis and hepatic insulin resistance; however, its regulatory mechanisms are not fully understood. "
2.	Hyperglycemia 03/01/2013 - "Recent work reveals that hyperglycemia in diabetes triggers nutrient excess in neurons that, in turn, mediates a phenotypic change in mitochondrial biology through alteration of the AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) signaling axis. " 06/01/2011 - "AMP-activated protein kinase (AMPK) activation has been shown to induce MnSOD and suppress hyperglycemia-induced mitochondrial ROS production in endothelial cells. " 01/01/2002 - "Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation." 08/22/2015 - "Rhizoma Anemarrhenae extract ameliorates hyperglycemia and insulin resistance via activation of AMP-activated protein kinase in diabetic rodents." 06/12/2013 - "This study found that dietary black soybean seed coat extract (BE) ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase (AMPK) in type 2 diabetic mice. "
3.	Reperfusion Injury 01/01/2012 - "Activation of the master energy-regulator AMP-activated protein kinase (AMPK) in the heart reduces the severity of ischemia-reperfusion injury (IRI) but the role of AMPK in renal IRI is not known. " 02/01/2015 - "Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway." 02/01/2015 - "Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury." 06/01/2004 - "Ischemia-reperfusion injury in the heart results in enhanced production of H2O2 and activation of AMP-activated protein kinase (AMPK). " 02/01/2010 - "Mechanical Stretch-Induced Protection against Myocardial Ischemia-Reperfusion Injury Involves AMP-Activated Protein Kinase."
4.	Obesity 09/01/2008 - "The AMP-activated protein kinase (AMPK) system is a key player in regulating energy balance at both the cellular and whole-body levels, placing it at centre stage in studies of obesity, diabetes and the metabolic syndrome. " 05/15/2008 - "The objective of this study was to evaluate effects of maternal obesity and over-nutrition on signalling of the AMP-activated protein kinase (AMPK) pathway in fetal skeletal muscle in an obese pregnant sheep model. " 07/01/2014 - "Viola mandshurica ethanolic extract prevents high-fat-diet-induced obesity in mice by activating AMP-activated protein kinase." 01/01/2014 - "AMP activated protein kinase (AMPK) regulates the coordination of anabolic and catabolic processes and is an attractive therapeutic target for T2DM, obesity and metabolic syndrome. " 10/15/2013 - "There is a global epidemic of obesity, and obesity is known to inhibit AMP-activated protein kinase (AMPK) activity and impairs myogenesis. "
5.	Fibrosis (Cirrhosis) 02/01/2015 - "Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis." 01/01/2014 - "In a number of tissues, AMP-activated kinase (AMPK) activation has been shown to inhibit fibrosis. " 07/01/2013 - "In parallel, R increased the activation of AMP-activated protein kinase (AMPK), a known inhibitor of fibrosis, in vivo and in vitro, and the anti-fibrotic effects of R were abrogated in fibroblasts transfected with AMPKα1/α2 siRNA. " 07/01/2013 - "HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome." 10/01/2009 - "Recently, it was found that dithiolethione compounds had the activities to prevent or treat fibrosis, insulin resistance, and mitochondrial protective effects in the liver by a mechanism involving AMP-activated protein kinase (AMPK) and/or 70-kDa ribosomal protein S6 kinase 1 (S6K1). "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Adiponectin
3.	Metformin (Glucophage)
4.	Glucose (Dextrose)
5.	AICA ribonucleotide (CAIR)
6.	Adenosine Monophosphate (AMP)
7.	Messenger RNA (mRNA)
8.	Berberine
9.	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)
10.	Nitric Oxide (Nitrogen Monoxide)

Related Therapies and Procedures

1.	Oral Administration
2.	Heterologous Transplantation (Xenotransplantation)
3.	Adjuvant Chemotherapy
4.	Caloric Restriction
5.	Bariatric Surgery