Lung Injury

Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.

Also Known As:

Chronic Lung Injury; Lung Injuries; Pulmonary Injury; Chronic Lung Injuries; E Cigarette Use Associated Lung Injury; E Cigarette or Vaping Product Use Associated Lung Injury; EVALIs; Injuries, Lung; Injuries, Pulmonary; Injury, Lung; Injury, Pulmonary; Lung Injuries, Chronic; Lung Injury, Chronic; Pulmonary Injuries; Vaping Product Use Associated Lung Injury; E-Cigarette Use-Associated Lung Injury; E-Cigarette or Vaping Product Use-Associated Lung Injury; EVALI; Vaping Product Use-Associated Lung Injury

Networked: 16608 relevant articles (1413 outcomes, 2331 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation (Inflammations)
2.	Sepsis (Septicemia)
3.	Hyperoxia
4.	Ischemia
5.	Pneumonia (Pneumonitis)

Experts

1.	Matthay, Michael A: 90 articles (06/2022 - 01/2000)
2.	Schultz, Marcus J: 65 articles (01/2022 - 10/2006)
3.	Garcia, Joe G N: 58 articles (04/2022 - 11/2003)
4.	Pelosi, Paolo: 48 articles (01/2022 - 11/2003)
5.	Zhang, Wei: 43 articles (09/2022 - 07/2003)
6.	Deitch, Edwin A: 37 articles (12/2014 - 06/2002)
7.	Slutsky, Arthur S: 36 articles (01/2022 - 06/2002)
8.	Cuzzocrea, Salvatore: 36 articles (10/2020 - 01/2002)
9.	Liu, Mingyao: 35 articles (11/2022 - 12/2002)
10.	Liu, Wei: 35 articles (02/2022 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lung Injury:

1.	CytokinesIBA 01/01/2020 - "The results showed that MSI-1 exerted effective anti-cryptococcal activity in vitro, with MICs of 8-16 μg/mL and MFCs of 8-32 μg/mL, and in a C neoformans-infected mouse model, with significantly improved animal survival, decreased production of pro-inflammatory cytokines and alleviated lung injury, because the potent and rapid fungicidal activity of MSI-1 could effectively eliminate fungal counts in mouse organs. " 01/01/2020 - "In the lungs of H5N1-infected mice, ZrO2 treatment led to less pathological lung injury, significant reduction in influenza A virus replication, and overexpression of pro-inflammatory cytokines. " 06/01/2006 - "Intermittent ventilation has protective effects on the lung injury during CPB by decreasing granulocyte adhesion and the level of lung cytokines, alleviating the lung inflammatory reaction and endothelial cell injury." 12/01/2022 - "Volume-control ventilation plus transvenous diaphragm neurostimulation on every breath improved [Formula: see text]/[Formula: see text], A-a gradient, and alveolar homogeneity, as well as reduced driving pressure, mechanical power, and mechanical work, and resulted in lower lung injury scores and tissue cytokine concentrations in a preclinical ARDS model.NEW & NOTEWORTHY Combining temporary transvenous diaphragm neurostimulation with volume-control ventilation on every breath, called negative-pressure-assisted ventilation, improved gas exchange and alveolar homogeneity in a preclinical model of moderate ARDS. " 12/01/2022 - "While both term and preterm hAEC-EVs reduced the levels of inflammatory cytokines on postnatal day 7, the improvement in lung injury was associated with increased type II alveolar cells which was only observed in term hAEC-EV treatment group. "
2.	Proteins (Proteins, Gene)FDA Link 11/01/1995 - "Treatment with EL-246 significantly reduced lung injury, as indicated by improved bronchoalveolar lavage protein and neutrophil content, resulting in a significant improvement in arterial oxygenation. " 04/01/2008 - "DMDP-treated animals at both time points exhibited protection against ventilation-induced lung injury, which included superior physiological parameters, lower protein leakage, and lower inflammatory mediator release into the air space, compared with animals not receiving DMDP. " 11/01/2014 - "Here, we present a review of SAP biology with an emphasis on SAP receptor interactions and how the effect of SAP on monocytes and macrophages has been explored to develop this protein as a therapeutic for renal and lung injuries. " 11/01/2014 - "This review focuses on the contribution of Trx family proteins toward normal and aberrant lung development, in particular, the roles of the Trx system in hyperoxic responses of alveolar epithelial cells, aberrant lung development in animal models of BPD, O2-dependent signaling processes, and possible therapeutic efficacy in preventing O2-mediated lung injury. " 10/01/2020 - "The aim of this study is to find the changes of protein that can be helpful in understanding blast-induced lung injury. "
3.	Bleomycin (Blenoxane)FDA LinkGeneric 01/07/2020 - "In a paired study in mice with bleomycin induced lung injury we show that the improved reactivity and affinity of Gd-CHyd results in significantly higher lung-to-liver contrast, e.g. " 01/01/2023 - "NecroX significantly improved the pathobiologic features of the PHMG- and bleomycin-induced lung injuries through regulation of mitochondrial oxidative stress. " 10/01/2012 - "We have observed significant protective effects of Tβ4 on bleomycin-induced lung damage, the main outcomes being the halting of the inflammatory process and a substantial reduction of histological evidence of lung injury." 07/01/2011 - "In conclusion, targeting CCL3/MIP-1α by treatment with evasin-1 is beneficial in the context of bleomycin-induced lung injury, even when treatment is started after the fibrogenic insult. " 05/01/2005 - "The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in an experimental model of lung injury caused by bleomycin administration. "
4.	AntioxidantsIBA 12/01/2012 - "While dietary wholegrain Flaxseed (FS) has potent anti-inflammatory, anti-fibrotic and antioxidant properties in murine models of acute and chronic lung injury, the main bioactive ingredient that contributes to these protective effects remains unknown. " 02/21/2023 - "In addition, we will highlight the limitations of current therapeutic strategies and explore new antioxidant-based drug options that could potentially be effective in managing acute and chronic lung injuries." 11/01/2018 - "Antioxidants have been found to be effective in alleviating lung injury and protecting against damage of other organs.The" 01/01/2013 - "The data showed that EPO pretreatment could be effective in reducing renal and lung injury following renal I/R and could improve the cellular antioxidant defense system. " 10/31/2023 - "This study investigated the protective effects of three antioxidants on radiationinduced lung injury. "
5.	Surface-Active Agents (Surfactants)IBA 02/01/2001 - "Since the efficacy of NAC in the prevention of NO2-induced impairments in the surfactant system is striking mainly in the continuously exposed group, we suggest that administration of NAC to NO2-induced lung injury partially restores altered BAL components and the impaired physiology of type II pneumocytes." 03/01/1999 - "In conclusion, rSP-C surfactant was effective in improving gas exchange in this model of lung injury, although higher doses were required for optimal responses. " 01/01/2001 - "Whereas short-term inhalation of alpha(1)-PI was beneficial for the proteolytic aspects of CF lung injury, this appeared not to be the case for surfactant conversion and surface activity." 08/15/2005 - "In a surfactant-deficient model of lung injury, the prone position improved gas exchange by restoring aeration and decreasing shunt while preserving perfusion in dorsal lung regions, and by making the distribution of ventilation more uniform." 01/01/2013 - " Because the inhibition of local immune response may decrease lung injury, surfactant therapeutic efficacy may be related not only to its biophysical characteristics but, at least in part, to its anti-inflammatory features and its effects on remodeling processes. "
6.	LipopolysaccharidesIBA 04/30/2020 - "Compared to the intravenous delivery, the intratracheal administration dramatically increased the drug availability in the lung tissue in rats by more than 80-fold, leading to an improved and prolonged local anti-inflammatory efficacy in a lipopolysaccharide induced lung injury model in mice. " 01/01/2018 - "This study aims to determine the protective effects of Nrf2-transfected human amniotic mesenchymal stem cells (hAMSCs) against lipopolysaccharide (LPS)-induced lung injury in mice. " 04/01/2015 - "In this study, we evaluated the effects of Cap on preventing lipopolysaccharide (LPS)-induced lung injury and further investigated the underlying mechanisms of these protective effects. " 03/15/2022 - "This review discusses mechanisms of protective effects of exercise in lipopolysaccharide (LPS)-induced lung injury. " 10/29/2019 - "A mouse model of lipopolysaccharide (LPS)-induced ALI was used to evaluate the levels of phosphorylated (p)-PKR and NLRP3 in lung tissue, and the protective effects of a PKR inhibitor on lung injury. "
7.	Oxygen (Dioxygen)IBA 01/01/2008 - "Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. " 10/15/2016 - "The treatment group had significant improvement in the ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen and lung injury score (p = 0.01), and similar timing to removal of vital organ support (HR 0.74, 95 % CI 0.51-1.07; p = 0.107). " 05/01/1993 - "Arterial oxygen tension and pulmonary compliance deteriorated abruptly after lung injury in all cats, and improved significantly (p < .001, two-way analysis of variance) 15 mins after perfluorochemical liquid lavage. " 03/01/1998 - "Intraperitoneal administration of MR1, either before or after oxygen exposure, was remarkably effective in reducing and in many cases preventing lung injury. " 05/01/2013 - "ADORA2A is protective against lung injury after LPS and oxygen. "
8.	EndotoxinsIBA 06/01/1993 - "To determine if thermal injury impairs pulmonary intravascular clearance of bacteria and therefore leads to exaggerated cardiopulmonary dysfunction in sheep, since endotoxin infusion has been previously shown to induce more severe pulmonary injury after thermal injury. " 01/01/2015 - "Subsequent in vivo studies examined the efficacy of aerosolized rAAV2/6 overexpressing the NF-κB inhibitor IκBα in a rodent endotoxin-induced lung injury model. " 01/01/2006 - "In this study, we aimed to investigate the efficacy of CAPE in endotoxin-induced lung injury in rats. " 12/01/2019 - "This study also revealed that RSV attenuates endotoxin-induced lung injury. " 01/01/2017 - "In line with our hypothesis, initial studies of endotoxin-induced lung injury revealed a marked protection of Tbet-/- mice, including attenuated neutrophilia compared to WT counterparts. "
9.	Interleukin-6 (Interleukin 6)IBA 01/01/2023 - "These data showed that Tan IIA significantly improved I/R-induced histological changes and scores of lung injury, decreased lung W/D ratio, MPO and MDA contents, reduced infiltration of inflammatory cells, and decreased the expression of IL-1β, IL-6 and TNF-α. " 02/01/2020 - "Compared with the LIRI group, the morphological and ultrastructural changes of the lung tissue in the DEX group were significantly improved, and the lung injury score was reduced (5.00±0.89 vs. 8.83±0.75), lung W/D ratio and TNF-α, IL-1β, IL-6 levels were significantly decreased [lung W/D ratio: 6.25±0.56 vs. 8.27±0.72, TNF-α (ng/L): 93.28±16.42 vs. 205.90±25.30, IL-1β (ng/L): 130.10±10.81 vs. 209.10±19.20, IL-6 (ng/L): 195.80±21.17 vs. 310.50±20.77], p-AKT expression was significantly increased [p-AKT/AKT: (57.58±8.80)% vs. (36.62±9.25)%], and the differences were statistically significant (all P < 0.05). " 01/01/2021 - "Treatment with rTEM1D1 improved survival and attenuated circulating TNF-α and IL-6, lung injury and pulmonary accumulation of leukocytes in LPS-challenged mice. " 01/01/2021 - "In vivo, TEM1D1 deletion improved survival in LPS-challenged mice with reduction of circulating TNF-α and IL-6 and alleviation of lung injury and pulmonary leukocyte accumulation. " 01/01/2020 - "Next, we showed that α1 -antitrypsin (AAT) expression improved lung injury by modulating the production of IL-6 in AMs and decreased polarization of AMs toward the M1 phenotype. "
10.	SmokeIBA 02/25/2020 - "Our data revealed that smoke inhalation induces miR-155 expression, and miR-155 knockout (KO) significantly ameliorates smoke-inhalation-induced lung injury in mice. " 05/01/2020 - "This study aimed to explore the protective effects of Dex against smoke-induced lung injury. " 02/01/2023 - "We investigated whether BCX has protective effects against cigarette smoke (CS)-induced lung injury, dependent or independent of BCO1/BCO2 and their metabolites. " 11/17/2021 - "Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice." 08/01/2018 - "We have found that adenoviral gene transfer of SOCS-1 ameliorates smoke inhalation-induced lung injury in C57BL/6 mice. "

Therapies and Procedures

1.	Therapeutics 01/01/2017 - "Of the various cell-based therapy options, mesenchymal stem/stromal cells (MSCs) from bone marrow, adipose tissue, and umbilical cord have the most experimental data to support their potential efficacy for lung injury from both infectious and noninfectious causes. " 01/01/2004 - "Novel therapy to activate lung stem/progenitor cells, ameliorate lung injury, augment lung repair and/or induce lung regeneration could be highly beneficial in both children and adults with intractable pulmonary insufficiency." 01/01/2021 - "Inflammatory crosstalk from the kidney to the lung has been shown to contribute to lung injury after AKI, but anti-inflammatory therapies have not been proven beneficial in human studies. " 06/16/2021 - "The therapy significantly improved the patient's clinical symptoms, oxygenation status, and radiological characteristics of lung injury during hospitalization, and the patient showed good tolerance and avoided intubation. " 01/31/2020 - "Stem-cell therapy is a promising way to improve lung injury and abnormal alveolarization, and the human umbilical cord (hUC) is a good source of mesenchymal stem cells (MSCs), which have demonstrated efficacy in other diseases. "
2.	Artificial Respiration (Mechanical Ventilation) 05/01/2013 - "The prone position (PP) has proven beneficial in patients with severe lung injury subjected to mechanical ventilation (MV), especially in those with lobar involvement. " 01/01/2022 - "Lung-protective mechanical ventilation improved oxygenation while minimising lung injury. " 09/01/2019 - "The AP is protective against lung injury and promotes lung development compared with mechanical ventilation in premature lambs." 01/01/2023 - "The prognosis may be improved by avoiding lung injury in the early stages of mechanical ventilation. " 01/01/2021 - "Variable assisted mechanical ventilation has been shown to improve lung function and reduce lung injury. "
3.	Ligation 05/01/2011 - "Bronchial circulation plays a significant role in lung injury after B&S injury, and reduction of bronchial blood flow by bronchial artery ligation reduces bronchial exudates, resulting in improved gas exchange." 02/01/1995 - "Splenic vein ligation provided similar protective effects on the liver, but did not affect lung injury. " 08/01/2022 - "The intestinal lymph duct ligation could alleviate SAP-induced pulmonary injury by suppressing NF-κB activation in rats." 01/01/2022 - "Reply to Jha: Addition of 5% CO2 to Inspiratory Gas in Preventing Lung Injury Due to Pulmonary Artery Ligation." 01/01/2022 - "Addition of 5% CO2 to Inspiratory Gas in Preventing Lung Injury Due to Pulmonary Artery Ligation."
4.	Mechanical Ventilators (Ventilator) 04/01/2005 - "Protective effects of low respiratory frequency in experimental ventilator-associated lung injury." 01/01/2023 - "Prone positioning has shown to improve mortality, whereas NMBAs are used to prevent ventilator asynchrony and reduce patient self-inflicted lung injury. " 10/01/2012 - "It frequently results in equivalent or improved oxygenation and ventilation at lower peak pressures than conventional ventilation, thus minimizing secondary ventilator-associated lung injury. " 01/01/2023 - "Our study investigated the impact of a single episode of lung injury on lung mechanics and the risk factors for ventilator-induced injury, compared with non-injured lungs. " 01/01/2020 - "Our findings suggest that postoperative PaO2/FIO2 may be a potential target for future prospective trials investigating the impact of specific ventilation strategies for reducing ventilator-induced pulmonary injury."
5.	Punctures 12/01/2022 - "Over-puncture pulmonary injury risk increases with the force used. " 06/01/2008 - "Laterally placed supra-12th rib punctures made during the normal ventilatory cycle have an acceptably low pleural morbidity and no risk of lung injury." 09/01/2011 - "The present study aimed to determine the protective effects and the underlying mechanisms of AS on septic lung injury induced by cecal ligation and puncture (CLP). " 01/01/2021 - "Knockdown of circN4bp1 inhibited the lung injury and improved the long-time survival through blunting the M1 macrophage activation in cecal ligation and puncture- (CLP-) induced ARDS mice. " 04/01/2003 - "In this experimental study, we investigated the role of chronically used NAC in septic lung injury on a cecal ligation and puncture (CLP) model. "