Opsins

Photosensitive proteins in the membranes of PHOTORECEPTOR CELLS such as the rods and the cones. Opsins have varied light absorption properties and are members of the G-PROTEIN-COUPLED RECEPTORS family. Their ligands are VITAMIN A-based chromophores.

Also Known As:

Networked: 291 relevant articles (4 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Palczewski, Krzysztof: 15 articles (01/2021 - 11/2002)
2.	Travis, Gabriel H: 10 articles (01/2017 - 09/2002)
3.	Neitz, Maureen: 8 articles (01/2019 - 05/2008)
4.	Jastrzebska, Beata: 7 articles (01/2022 - 12/2004)
5.	Hauswirth, William W: 6 articles (01/2019 - 01/2004)
6.	Neitz, Jay: 6 articles (01/2019 - 05/2008)
7.	Flannery, John G: 5 articles (02/2021 - 01/2004)
8.	Batabyal, Subrata: 5 articles (01/2021 - 10/2017)
9.	Mohanty, Samarendra: 5 articles (01/2021 - 10/2017)
10.	Wright, Weldon: 5 articles (01/2021 - 10/2017)

Related Diseases

1.	Photophobia (Light Sensitivity) 05/01/2015 - "Microbial opsins with improved light sensitivity and red-shifted action spectra allow optogenetic stimulation at light levels well below the safety threshold in the human eye. " 10/27/2022 - "The goal of the present study was to test a new generation of LMOs based on opsins with higher light sensitivity which will allow for peripheral delivery of the CTZ. " 01/01/2023 - "The photocycle of visual opsins is essential to maintain the light sensitivity of the retina. " 01/01/2022 - "A detailed theoretical analysis of ChETA co-expressed with different SFOs, namely ChR2(C128A), ChR2(C128S), stabilized step-function opsin (SSFO) and step-function opsin with ultra-high light sensitivity (SOUL), expressing hippocampal neurons has been carried out by formulating their accurate theoretical models.Main" 01/01/2021 - "Newly discovered opsins with high light sensitivity and fast temporal kinetics can provide sufficient temporal resolution at safe light powers and overcome the limitations of presently used opsins. "
2.	Blue cone monochromatism 01/01/2019 - "Our results showing that the remaining M-opsin dominant cones in aged Opn1mw-/- mice can still be rescued by gene therapy is helpful for establishing the window of treatability in future blue cone monochromacy clinical trials." 01/01/2018 - "Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy." 01/01/2016 - "Blue cone monochromacy (BCM) is an X-linked condition caused by a loss-of-function of both the OPN1LW and OPN1MW opsin genes. " 01/01/2023 - "Blue cone monochromacy (BCM) is a rare X-linked retinal disease characterized by the absence of L- and M-opsin in cone photoreceptors, considered a potential gene therapy candidate. "
3.	Seizures (Absence Seizure) 02/15/2016 - "Although invasive due to the need to inject a viral vector into the brain and implant a device to deliver light to opsin-transduced neurons, this approach has the potential to be effective in suppressing spontaneous seizures while avoiding the side-effects of anti-epileptic drugs (AEDs) or the need to permanently excise regions of the brain. " 11/01/2014 - "Opsins allow selective activation of excitatory neurons and inhibitory interneurons, or subclasses of interneurons, to study their activity patterns in distinct brain-states in vivo and to dissect their role in generation of synchrony and seizures. " 06/01/2013 - "By introducing viral vectors carrying algal-derived cation or anion channels, known as opsins, neurons that initiate or propagate seizures may be silenced. "
4.	Ventricular Fibrillation 12/01/2016 - "Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study." 12/01/2016 - "This study aimed to (1) assess the feasibility of terminating sustained ventricular fibrillation (VF) via light-induced excitation of opsins expressed throughout the myocardium and (2) identify the ideal (theoretically possible) opsin properties and light source configurations that would maximise therapeutic efficacy. "
5.	Retinal Degeneration 11/17/2022 - "In conclusion, our study establishes an appropriate zebrafish model for TULP1-associated retinal degeneration and proposes that loss of TULP1 causes defects in cilia structure and opsin trafficking through the downregulation of tekt2, which further increases the death of photoreceptors via ferroptosis. " 08/04/2006 - "Thus, our study reveals a novel molecular mechanism for retinal degeneration that results from deficient export of opsin from the Golgi apparatus." 05/01/1993 - "An immunohistochemical study of opsin in photoreceptor cells following light-induced retinal degeneration in the rat." 11/11/2022 - "Here, we investigate whether bReaChES, a newly described high sensitivity Type I opsin with peak sensitivity to long-wavelength visible light, can restore vision in a murine model of severe early-onset retinal degeneration. " 11/01/2021 - "Variants in IFT122 have not been associated with retinal degeneration in mammals, but the loss of ift122 in zebrafish larvae impaired opsin transport and resulted in progressive photoreceptor degeneration. "

Related Drugs and Biologics

1.	Opsins
2.	Retinaldehyde (Retinal)
3.	Proteins (Proteins, Gene)
4.	Retinal Pigments (Pigments, Visual)
5.	melanopsin
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Antibodies
8.	Immune Sera (Antisera)
9.	Thyrotropin-Releasing Hormone (Protirelin)
10.	Oxygen (Dioxygen)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Cannula
4.	Visual Prosthesis
5.	Intraocular Injections