Adenomyoepithelioma

A mixed epithelial and myoepithelial neoplasm usually encountered within the breast. It is a multinodular lesion presenting with a bicellular pattern of proliferating epithelial and myoepithelial cells, which are regularly distributed in the glandular structures.

Also Known As:

Networked: 31 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Neoplasms (Cancer)
3.	Phyllodes Tumor (Cystosarcoma Phylloides)
4.	Papilloma (Papillomatosis)
5.	Muscle Tissue Neoplasms

Experts

1.	Reis-Filho, J S: 2 articles (01/2004 - 01/2001)
2.	Ichihara, Shu: 1 article (02/2015)
3.	Iwakoshi, Akari: 1 article (02/2015)
4.	Moritani, Suzuko: 1 article (02/2015)
5.	Yatabe, Yasushi: 1 article (02/2015)
6.	Nagai, Yuichiro: 1 article (02/2015)
7.	Asai, Masami: 1 article (02/2015)
8.	Yuba, Yoshiaki: 1 article (02/2015)
9.	Jijiwa, Mayumi: 1 article (02/2015)
10.	Ujihira, Nobuko: 1 article (02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adenomyoepithelioma:

1.	9,10-Dimethyl-1,2-benzanthracene (DMBA)IBA 03/01/1990 - "It is suggested that DMBA-induced mouse mammary gland adenomyoepitheliomas and myoepithelial carcinomas may serve as very useful animal models to study myoepithelial tumorigenesis."
2.	methylamphotericin B (AME)IBA 09/01/2014 - "Adenomyoepithelioma (AME) of breast is a low grade malignant biphasic tumour, usually seen in elderly women as a firm, well circumscribed tumour having both glandular and myoepithelial cells. " 06/01/2011 - "This review describes the classification, clinical presentation, pathological features and clinical behaviour of adenomyoepithelioma (AME) of the breast. " 05/01/2010 - "Collagenous spherulosis (CS) associated with an adenomyoepithelioma (AME) of the breast is rare. " 09/01/2011 - "Adenomyoepithelioma (AME) is a rare benign tumor composed of myoepithelial cells (MECs) which are located beneath the epithelial cells of exocrine glands, especially in breast and salivary glands. " 03/01/2009 - "Presented herein is the first case of malignant adenomyoepithelioma (malignant AME) of the breast combined with invasive lobular carcinoma (ILC) in a 53-year-old woman. "
3.	Phenobarbital (Luminal)FDA Link 05/01/2013 - "Adenomyoepithelioma of the breast is an uncommon tumor characterized by dual differentiation into luminal cells and myoepithelial cells. " 01/01/2004 - "Adenomyoepithelioma is a biphasic neoplasm of the breast, composed of both luminal epithelial and myoepithelial cells. " 01/01/1988 - "Histologically, the tumor demonstrated the characteristic bicellular differentiation of luminal epithelial and myoepithelial cells reported in previous adenomyoepitheliomas of the breast. "
4.	Pseudoangiomatous stromal hyperplasiaIBA 05/01/2008 - "In the biphasic lesions with predominance of spindle cells with benign epithelial component, fibroepithelial lesions including fibroadenomas and phyllodes tumors are the most common, followed by pseudoangiomatous stromal hyperplasia, hamartoma and adenomyoepithelioma. " 11/01/2004 - "Herein we offer advice on avoiding common diagnostic errors and on considering the relevant differential diagnosis of mucocele-like lesions, spindle-cell metaplastic carcinoma, adenomyoepithelioma, pseudoangiomatous stromal hyperplasia (PASH), collagenous spherulosis, myofibroblastoma, vascular lesions, and lymphoid infiltrates in the breast." 01/01/2015 - "Following histopathological, immunohistochemical, and clinical evaluations, the patients were diagnosed as follows: pseudoangiomatous stromal hyperplasia (PASH), bilateral desmoid-type fibromatosis (FM), adenomyoepithelioma (AME), myofibroblastoma (MFB), malignant phyllodes tumor (MF), high-grade AS, post-chemotherapy osteosarcoma (OS) + Paget's disease, and metaplastic carcinoma (MC). "
5.	Keratin-5 (Keratin 5)IBA 02/01/2015 - "To determine which immunohistochemical markers are useful for the identification of neoplastic myoepithelial cells in adenomyoepithelioma of the breast, the expression of seven myoepithelial markers (α-smooth muscle actin (α-SMA), calponin, p63, CD10, cytokeratin 5/6, cytokeratin 14, and S-100) was examined in 19 lesions from 16 patients. "
6.	Keratin-14 (Keratin 14)IBA 02/01/2015 - "To determine which immunohistochemical markers are useful for the identification of neoplastic myoepithelial cells in adenomyoepithelioma of the breast, the expression of seven myoepithelial markers (α-smooth muscle actin (α-SMA), calponin, p63, CD10, cytokeratin 5/6, cytokeratin 14, and S-100) was examined in 19 lesions from 16 patients. "
7.	Activins (Activin)IBA 08/01/1999 - "A cross-sectional study comparing the expression of inhibin/activin subunits alpha, betaA and betaB in surgical specimens from women undergoing reductive mammoplasty (classified, according to the phase of the menstrual cycle, as follicular, luteal, or postmenopausal), and patients submitted to lumpectomy for fibrocystic disease, benign (intraductal papilloma, adenomyoepithelioma, and hamartoma) or malignant breast neoplams (intraductal, intralobular, and invasive carcinoma). "
8.	Cyclin D1IBA 10/01/2008 - "All PLAG1-induced adenomyoepitheliomas revealed expression upregulation of Igf2/H19, Dlk1/Gtl2, Igfbps and Wnt signaling genes (Wnt6, Cyclin D1). "
9.	Mucin-1 (CA 15-3 Antigen)IBA 07/01/2012 - "The diagnosis of adenomyoepithelioma was confirmed by the presence of a biphasic immunoprofile, with expression of cytokeratins and epithelial membrane antigen in the glandular epithelium and with expression of vimentin and smooth muscle actin in the myoepithelial cells. "
10.	VimentinIBA 07/01/2012 - "The diagnosis of adenomyoepithelioma was confirmed by the presence of a biphasic immunoprofile, with expression of cytokeratins and epithelial membrane antigen in the glandular epithelium and with expression of vimentin and smooth muscle actin in the myoepithelial cells. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 11/01/2010 - "Breast MRI for monitoring images of an "adenomyoepithelioma with malignant features", before, during, and after chemotherapy." 01/01/2015 - "Following histopathological, immunohistochemical, and clinical evaluations, the patients were diagnosed as follows: pseudoangiomatous stromal hyperplasia (PASH), bilateral desmoid-type fibromatosis (FM), adenomyoepithelioma (AME), myofibroblastoma (MFB), malignant phyllodes tumor (MF), high-grade AS, post-chemotherapy osteosarcoma (OS) + Paget's disease, and metaplastic carcinoma (MC). "
2.	Mammaplasty (Breast Reconstruction) 08/01/1999 - "A cross-sectional study comparing the expression of inhibin/activin subunits alpha, betaA and betaB in surgical specimens from women undergoing reductive mammoplasty (classified, according to the phase of the menstrual cycle, as follicular, luteal, or postmenopausal), and patients submitted to lumpectomy for fibrocystic disease, benign (intraductal papilloma, adenomyoepithelioma, and hamartoma) or malignant breast neoplams (intraductal, intralobular, and invasive carcinoma). "
3.	Simple Mastectomy 03/01/2002 - "Subsequent simple mastectomy and wide local excision were performed on cases 1 and 2, respectively, revealing focal carcinomatous transformation in the adenomyoepitheliomas. "
4.	Segmental Mastectomy (Lumpectomy) 08/01/1999 - "A cross-sectional study comparing the expression of inhibin/activin subunits alpha, betaA and betaB in surgical specimens from women undergoing reductive mammoplasty (classified, according to the phase of the menstrual cycle, as follicular, luteal, or postmenopausal), and patients submitted to lumpectomy for fibrocystic disease, benign (intraductal papilloma, adenomyoepithelioma, and hamartoma) or malignant breast neoplams (intraductal, intralobular, and invasive carcinoma). "