Cystatin A

A cytastin subtype found at high levels in the SKIN and in BLOOD CELLS. Cystatin A incorporates into the cornified cell envelope of stratified squamous epithelial cells and may play a role in bacteriostatic properties of skin.

Also Known As:

Networked: 81 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kos, Janko: 6 articles (10/2011 - 01/2002)
2.	Lah, Tamara T: 3 articles (05/2010 - 01/2002)
3.	Kos, J: 3 articles (03/2001 - 01/2000)
4.	Lu, Aiying: 2 articles (01/2015 - 11/2014)
5.	Zheng, Yuming: 2 articles (01/2015 - 11/2014)
6.	Tang, Minzhong: 2 articles (01/2015 - 11/2014)
7.	Gao, Jianquan: 2 articles (01/2015 - 11/2014)
8.	Nitoiu, Daniela: 2 articles (01/2015 - 10/2011)
9.	Zhong, Weiming: 2 articles (01/2015 - 11/2014)
10.	Kelsell, David P: 2 articles (01/2015 - 10/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1980 - "[Demonstration of an epidermal SH-protease inhibitor in normal epithelium and in some human neoplasms--an immunological study (author's transl)]." 01/01/2015 - "Both MIP-3α and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. " 01/01/2015 - "Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin a deregulation and a potential role in cell-cell adhesion." 10/01/2011 - "Using the stefin A concentration difference in matched pairs of tissue samples as a stratifying variable, 53 cases were found to be upregulated (higher concentrations in tumor samples than in nontumorous mucosa) and 39 cases downregulated. " 08/01/2007 - "Stefin A was upregulated in 53 patients (higher concentrations were measured in tumor samples than in nontumorous mucosa) and was downregulated in 39 patients. "
2.	Carcinoma (Carcinomatosis) 08/01/2007 - "Stefin A was recognized as a promising candidate marker for prognosis in patients with operable carcinoma of the head and neck." 03/01/2003 - "Cystatin A was expressed in the basal cells in all cases of BPH, low-grade PIN, and high-grade PIN whereas carcinomas showed no staining of cystatin A. " 03/01/2003 - "Previously it has been shown that cystatin A is expressed in the basal cells of normal prostate and the expression disappears in prostatic carcinoma. " 02/01/1998 - "We wanted to assess the biological and clinical significance of cystatin A in infiltrative breast carcinoma by immunohistochemical staining. " 03/01/2003 - "The results show that cystatin expression can be used as an aid in the diagnosis of prostatic adenocarcinoma and especially cystatin A in the distinction between high grade PIN and grade I carcinoma."
3.	Prostatic Neoplasms (Prostate Cancer) 09/15/2001 - "This is the first report to define heterogeneity within any Gleason score for prostate cancers by the ratios of CB to stefin A." 09/15/2001 - "Statistical analyses showed prostate cancer cases with ratios of CB > stefin A (P < 0.05) and CB < stefin A (P < 0.05) significantly different from normal prostate and BPH which had ratios of CB = stefin A. " 09/15/2001 - "We found considerable variability in individual localization of CB and stefin A within and between Gleason histologic scores for prostate cancers. " 09/15/2001 - "Our objective was to identify patterns of distribution of CB and its endogenous cellular inhibitor stefin A in cryostat sections of frozen BPH and prostate cancer tissue samples and to define these patterns in relation to Gleason histologic scores, clinical stages, and serum total PSA levels. " 07/01/1999 - "Our data showed that there were prostate cancer cases within Gleason histologic scores which expressed high, similar, and low levels of CB when compared to stefin A. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/1992 - "In squamous cell carcinoma, cystatin A was often abundant in highly differentiated areas and almost absent in poorly differentiated ones. " 12/15/2005 - "The aim of this study is to investigate the role of stefin A in human esophageal squamous cell carcinoma cells and to evaluate the possibility of stefin A for cancer therapy. " 01/01/1992 - "Cystatin A was also found in neoplastic lesions (dysplasia, carcinoma in situ and squamous cell carcinoma), but less abundant than in normal squamous epithelium. " 12/15/2005 - "We stably transfected stefin A cDNA into human EC9706 or KYSE150 esophageal squamous cell carcinoma cells. " 12/15/2005 - "Our data strongly indicate that stefin A plays an important role in the growth, angiogenesis, invasion, and metastasis of human esophageal squamous cell carcinoma cells and suggest that stefin A may be useful in cancer therapy."
5.	Melanoma (Melanoma, Malignant) 06/01/2006 - "In the present study, we investigated the expression and localization of the lysosomal cysteine proteinase cathepsin B and its natural inhibitors cystatin A, B and C in high- (MV3), intermediate- (SKmel28) and low-invasive (SKmel23, WM164) human melanoma cell lines grown on plastic or in contact with monomeric or fibrillar collagen type I. Neither the transcript levels of cathepsin B nor those of the natural inhibitors, cystatin B and C, were altered by the interaction of melanoma cells with collagen type I. However, protein expression and cellular localization of cathepsin B and its inhibitors were markedly affected. "

Related Drugs and Biologics

1.	Cystatin B
2.	Cystatins
3.	Cathepsin B
4.	Cysteine Proteases (Cysteine Protease)
5.	Cystatin C
6.	Cathepsin L
7.	Cathepsins
8.	Proteins (Proteins, Gene)
9.	Messenger RNA (mRNA)
10.	Collagen Type I (Type I Collagen)

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Aftercare (After-Treatment)