Mucin 5AC

A gel-forming mucin that is primarily found on the surface of gastric epithelium and in the RESPIRATORY TRACT. Mucin 5AC was originally identified as two distinct proteins, however a single gene encodes the protein which gives rise to the mucin 5A and mucin 5C variants.

Also Known As:

Networked: 108 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Batra, Surinder K: 3 articles (01/2022 - 01/2021)
2.	Cox, Jesse L: 3 articles (01/2022 - 01/2021)
3.	Ganguly, Koelina: 3 articles (01/2022 - 01/2021)
4.	Kumar, Sushil: 3 articles (01/2022 - 01/2021)
5.	Zhang, Ping: 2 articles (09/2022 - 09/2021)
6.	Atri, Pranita: 2 articles (01/2022 - 01/2021)
7.	Bernreuther, Christian: 2 articles (01/2022 - 08/2021)
8.	Boucher, Richard C: 2 articles (01/2022 - 01/2019)
9.	Burandt, Eike: 2 articles (01/2022 - 08/2021)
10.	Clauditz, Till: 2 articles (01/2022 - 08/2021)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 05/20/2023 - "Mucin 5AC is overexpressed in pancreatic cancer but absent in normal pancreas tissue. " 01/01/2022 - "Secreted mucin 5AC (MUC5AC) promotes pancreatic cancer (PC) progression and chemoresistance, suggesting its clinical association with poor prognosis. " 01/01/2022 - "Mucin 5AC expression is unrelated to pancreatic cancer aggressiveness." 01/01/2021 - "Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness." 05/23/2010 - "RNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells."
2.	Cholangiocarcinoma 08/14/2023 - "Plasma Bile Acid Profiling and Modulation of Secreted Mucin 5AC in Cholangiocarcinoma." 03/01/2019 - "Expression and Serum Levels of Mucin 5AC (MUC5AC) as a Biomarker for Cholangiocarcinoma: a Meta-analysis." 08/01/2011 - "A novel serum carbohydrate marker on mucin 5AC: values for diagnostic and prognostic indicators for cholangiocarcinoma." 03/25/2021 - "Potential biomarkers which include S100 calcium binding protein A9 (S100A9), mucin 5AC (MUC5AC), transforming growth factor β1 (TGF-β1), and angiopoietin-2 have previously been shown to be effective for cholangiocarcinoma (CCA) diagnosis. " 03/01/2005 - "We studied the expression of cytokeratin 7 (CK7), cytokeratin 17 (CK17), cytokeratin 20 (CK20), CDX2, mucin 1 (MUC1), mucin 2 (MUC2), and mucin 5AC (MUC5AC) in 46 cases of pancreatic ductal carcinoma, 18 ampulla of Vater adenocarcinomas, and 24 intrahepatic cholangiocarcinomas. "
3.	Neoplasm Metastasis (Metastasis) 05/20/2023 - "The present proof-of-concept study demonstrates the efficacy of an anti-mucin 5AC antibody conjugated to an IR800 dye (MUC5AC-IR800) to preferentially label a liver metastasis of pancreatic cancer (Panc Met) in a unique patient-derived orthotopic xenograft (PDOX) model. " 01/01/2015 - "The epithelial origin of distant metastasis was established by IF using villin (VIL1) and mucin 5AC (MUC5AC) antibodies. " 01/01/2022 - "Mucin 5AC expression was unrelated to tumor phenotype (tumor stage, tumor grade, lymph node, and distant metastasis), and microsatellite instability in ductal adenocarcinomas and carcinomas of the ampulla Vateri. "
4.	Fibrosis (Cirrhosis) 01/01/2021 - "However, mice treated with iEVs showed clinico-pathological improvement, decreased intestinal fibrosis and angiogenesis and a striking increase in intestinal expression of Mucin 5ac, suggesting improved epithelial function. "
5.	Inflammation (Inflammations) 01/01/2019 - "This atypical fungus associates to increased mucin 5AC (MUC5AC), a central effector of Th2-type allergic inflammation, in infant lungs. " 09/01/2023 - "PM2.5 can cause airway inflammation and promote the excessive secretion of mucin 5ac (Muc5ac), which can further induce many respiratory diseases. " 07/01/2023 - "This study aimed to evaluate the impact of miR-214 on lipopolysaccharide (LPS)-mediated inflammation, and mucin 5AC (MUC5AC) expression in human nasal epithelial cells. " 01/01/2021 - "The purpose of this study was to evaluate the effect of pepsin on mucin 5AC (MUC5AC) expression in upper and lower airway epithelial cells as an important potential factor of non-acidic GR-related airway inflammation. " 01/01/2023 - "Mucin 5AC (MUC5AC), a major gel-forming secretory mucin, is overexpressed in airway inflammation. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Angiopoietin-2
3.	Transforming Growth Factors (Transforming Growth Factor)
4.	Coloring Agents (Dyes)
5.	Calcium-Binding Proteins
6.	Cytokines
7.	Mucin-2
8.	ErbB Receptors (EGF Receptor)
9.	Antigens
10.	Keratin-20 (Cytokeratin 20)

Related Therapies and Procedures

1.	Eyeglasses (Spectacles)