Bronchomalacia

A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the BRONCHI. This results in a floppy bronchial wall making patency difficult to maintain. It is characterized by wheezing and difficult breathing.

Also Known As:

Networked: 80 relevant articles (8 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pathologic Constriction (Stenosis)
2.	Tracheomalacia
3.	Asthma (Bronchial Asthma)
4.	Infection
5.	Tuberculosis (Tuberculoses)

Experts

1.	Mehta, Atul C: 2 articles (01/2009 - 09/2005)
2.	Macchiarini, Paolo: 2 articles (12/2008 - 09/2002)
3.	Kapoor, Baljendra S: 2 articles (05/2007 - 05/2004)
4.	Chhajed, P N: 2 articles (11/2004 - 12/2001)
5.	Tamm, M: 2 articles (11/2004 - 12/2001)
6.	Keenan, R J: 2 articles (07/2000 - 01/2000)
7.	de Miguel Poch, Eduardo: 1 article (09/2015)
8.	López-Padilla, Daniel: 1 article (09/2015)
9.	García-Luján, Ricardo: 1 article (09/2015)
10.	de Pablo, Alicia: 1 article (09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bronchomalacia:

1.	Polypropylenes (Polypropylene)IBA 11/01/1992 - "A case of Saber-sheath type tracheo-bronchomalacia complicating bronchial asthma was treated by external fixation of Marlex mesh, and good results were obtained. " 10/01/1982 - "A silastic reinforced marlex mesh splint was inserted surgically to support a collapsing airway in 3 children with tracheomalacia and 1 with bronchomalacia. "
2.	Tracheal agenesisIBA 05/01/1994 - "Temporary or permanent tracheal splinting in pediatric patients may be indicated in tracheomalacia or bronchomalacia, repair of congenital tracheal stenosis, and after tracheal resection. " 07/01/1995 - "Three children had severe tracheal stenosis after tracheoplasty for congenital tracheal stenosis repair, and four had tracheomalacia or bronchomalacia with or without vascular compression. " 06/01/1992 - "The lesions included subglottic stenosis (24), congenital tracheal stenosis (9), tracheomalacia (15), bronchomalacia (6), and others (4). "
3.	SiliconesIBA 12/01/2006 - "A literature review yielded no prior reports of bronchomalacia in a cystic fibrosis patient being treated with a silicone stent. " 12/01/2006 - "Treatment of bronchomalacia in cystic fibrosis by silicone stent." 11/01/2004 - "Balloon dilatation and insertion of silicone or metallic airway stents can be undertaken to treat benign and malignant strictures or bronchomalacia. "
4.	Congenital lobar emphysemaIBA 05/01/2004 - "Congenital lobar emphysema (CLE) is characterized by unilobar alveolar distension secondary to bronchomalacia or absent cartilage. " 12/01/1994 - "The patients were a four month old with bronchial cartilage hypoplasia presenting as congenital lobar emphysema; a one month old with segmental bronchomalacia; a one month old with tracheal bronchus; a two day old and a seven month old with aneurysmal distension of the pulmonary arteries secondary to tetralogy of Fallot, with absent pulmonary valve and atrioventricular canal with pulmonary poststenotic dilatation, respectively; a three year old with double aortic arch forming a vascular ring; and a three month old with tracheomalacia from tracheoesophageal fistula. "
5.	Phenobarbital (Luminal)FDA Link 10/01/2009 - "In four patients, the percentages of luminal narrowing were 63.4% and 51.2%, respectively for tracheomalacia and 59.2% and 62.0%, respectively, for bronchomalacia. "
6.	AntigensIBA 12/13/2008 - "We removed cells and MHC antigens from a human donor trachea, which was then readily colonised by epithelial cells and mesenchymal stem-cell-derived chondrocytes that had been cultured from cells taken from the recipient (a 30-year old woman with end-stage bronchomalacia). "
7.	Lung agenesisIBA 01/01/1966 - "[Right pulmonary agenesis and left bronchomalacia. "
8.	Idiopathic pulmonary hemosiderosisIBA 06/01/2008 - "The most common cause was respiratory infection (n=39),followed by bronchial foreign bodies (n=19), upper airway cough syndrome (n=17), bronchial asthma or cough variant asthma (n=17), bronchomalacia (n=7), bronchial congenital malformation (n=5), primary ciliary dyskinesia (n=3), gastro-esophageal reflux (n=3), bronchial tumor (n=2), bronchial tuberculosis (n=1), pulmonary fibrosis (n=1) and idiopathic pulmonary hemosiderosis (n=1). "
9.	Familial duodenal atresiaIBA 03/01/1993 - "She also had a unilateral cleft lip, camptodactyly, duodenal atresia, tracheomalacia, bronchomalacia, and Tetralogy of Fallot."
10.	Coarctation of the aortaIBA 09/01/2003 - "A male infant presenting with severe heart failure and respiratory distress was diagnosed with a hypoplastic right lung, scimitar syndrome with pulmonary sequestration and multiple anomalous systemic arteries, left bronchomalacia, a large atrial septal defect and coarctation of the aorta. "

Therapies and Procedures

1.	Stents 12/01/2001 - "Mean improvement in FEV(1) for patients treated with stent insertion for bronchomalacia was 673 +/- 30 mL or 81 +/- 24%. " 04/01/2014 - "Bronchial stent placement in a dog with bronchomalacia and left atrial enlargement." 02/01/2009 - "In 2 children metal stents were inserted into the bronchus for the treatment of bronchomalacia, one was successful and the other needed re-insertion of stent again, these two patients underwent balloon-dilatation in distal part of stent afterwards. " 09/15/2005 - "Two of these patients required repeat stent insertion after removal, due to bronchomalacia. " 06/01/2005 - "This stent may be the stent of choice in the treatment of tracheo- and bronchomalacia."
2.	Lung Transplantation 09/01/2015 - "Oki stenting for anastomotic bronchomalacia in lung transplantation." 01/01/1992 - "[Diffuse bronchomalacia after double lung transplantation. " 09/01/2015 - "For both stenosis and bronchomalacia in lung transplantation, we propose Oki stenting as the first choice of treatment. " 02/01/1998 - "A hypothesis may be made that a combination of proximal cartilage deficiency and posttransplant airway ischemia led to the development of bronchomalacia after lung transplantation. " 11/01/1998 - "Use of balloon-expandable metallic stents in the management of bronchial stenosis and bronchomalacia after lung transplantation."
3.	Continuous Positive Airway Pressure 05/01/1978 - "Two children with severe bronchial collapse secondary to bronchomalacia improved dramatically after institution of continuous positive airway pressure (CPAP). " 05/01/2014 - "An asthmatic patient with bronchomalacia and good response with continuous positive airway pressure." 02/01/1986 - "Continuous positive airway pressure (CPAP) was used to treat severe respiratory distress in four infants with bronchomalacia. " 02/01/1986 - "Effectiveness of continuous positive airway pressure in the treatment of bronchomalacia in infants: a bronchoscopic documentation."
4.	Tracheotomy 06/01/2003 - "A second child required a tracheotomy for bronchomalacia at 6 months and died at 9 months with tracheotomy tube occlusion. " 10/01/2012 - "Bronchoscopy revealed tracheomalacia in 1 patient that was relieved by aortopexy; the other patient had bronchomalacia requiring tracheotomy. " 01/01/2008 - "He required tracheotomy after early respiratory failure, and some mild bronchomalacia was noted. "
5.	Artificial Respiration (Mechanical Ventilation) 02/01/2007 - "We found that noninvasive mechanical ventilation support is a low risk and highly effective treatment of infants and children with respiratory distress caused by bronchomalacia." 02/01/2007 - "To describe an effective treatment of a boy with bronchomalacia by noninvasive mechanical ventilation support. " 01/01/1990 - "Of the 6 patients alive after bronchial anastomosis, 3 recovered uneventfully and 3 who had required prolonged postoperative mechanical ventilation developed bronchomalacia. " 03/01/2008 - "Isolated bronchomalacia in the absence of tracheal involvement occurs more commonly in children and in adults with emphysema, chronic bronchitis, extrinsic compression by tumors, compression by abnormal blood vessels or vascular rings, relapsing polychondritis, endotracheal intubation and mechanical ventilation, enlarged left atrium, trauma, and lung transplantation. "