Tracheomalacia

A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the TRACHEA. This results in a floppy tracheal wall making patency difficult to maintain. It is characterized by wheezing and difficult breathing.

Also Known As:

Networked: 266 relevant articles (13 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bronchomalacia
2.	Tracheal Stenosis
3.	Pathologic Constriction (Stenosis)
4.	Cartilage Fractures
5.	Hypoparathyroidism

Experts

1.	Nishijima, Eiji: 4 articles (06/2012 - 12/2003)
2.	Muraji, Toshihiro: 3 articles (03/2011 - 12/2003)
3.	Tsugawa, Chikara: 3 articles (10/2008 - 12/2003)
4.	Yoshimura, Naoki: 3 articles (10/2008 - 12/2003)
5.	Yamaguchi, Masahiro: 3 articles (10/2008 - 12/2003)
6.	Oshima, Yoshihiro: 2 articles (06/2012 - 10/2008)
7.	Mishra, Anjali: 2 articles (05/2012 - 04/2012)
8.	Agarwal, Amit: 2 articles (04/2012 - 04/2007)
9.	Zurakowski, David: 2 articles (01/2011 - 05/2010)
10.	Boiselle, Phillip M: 2 articles (05/2010 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tracheomalacia:

1.	Tracheal agenesisIBA 06/01/2012 - "The aim of this study was to evaluate efficacy of aortopexy for preventing postoperative tracheomalacia after reconstruction of congenital tracheal stenosis. " 06/01/2012 - "Aortopexy with tracheal reconstruction for postoperative tracheomalacia in congenital tracheal stenosis." 01/01/2007 - "Polyflex stenting of tracheomalacia after surgery for congenital tracheal stenosis." 02/01/1995 - "We report a case of congenital tracheal stenosis with tracheomalacia, which shows unique histological findings. " 02/01/1995 - "[A case of congenital tracheal stenosis with tracheomalacia due to esophageal remnants]."
2.	Stanozolol (Winstrol)FDA Link 01/01/2011 - "The objective of this study is to determine the efficacy of stanozolol in the treatment of tracheal collapse (TC) in dogs, which is the analogous disease to tracheomalacia (TM) in humans. "
3.	Pyridostigmine Bromide (Pyridostigmine)FDA LinkGeneric 10/01/1991 - "A 14-day course of pyridostigmine did not elicit any clinical improvement in the elder sibling, in whom tracheomalacia was diagnosed by chest fluoroscopy and bronchoscopy. "
4.	tranilast (N 5')IBA 09/01/2011 - "If tracheomalacia was diagnosed intraoperatively, the patients were left intubated and taken to the intensive care unit (ICU) (n = 5). " 01/01/1999 - "Tracheomalacia was the most common indication (n = 5). " 03/01/1990 - "The diagnoses included aortic arch anomalies (n = 7), innominate artery compression (n = 13), pulmonary artery compression (n = 5), and tracheomalacia (n = 2). " 07/01/2003 - "Late complications consisted of gastroesophageal reflux ( n = 5) and tracheomalacia ( n = 1); these conditions required endoscopic correction in, respectively, two and one cases. " 04/01/2005 - "Ten infants (median age 9.5 months, range 3-18) with laryngomalacia (n=5), tracheomalacia (n=3), tracheal hypoplasia (n=1), and Pierre Robin syndrome (n=1). "
5.	Phenobarbital (Luminal)FDA Link 05/01/2010 - "The study group consisted of 15 consecutively registered pediatric patients (younger than 18 years) who had tracheomalacia, defined as 50% or greater reduction in tracheal cross-sectional luminal area between end inspiration and end expiration, diagnosed with MDCT and confirmed with bronchoscopy. " 01/01/2009 - "Overall, 10.5% of men and 17.1% of women showed evidence of tracheomalacia on the basis of the criterion of a reduction of 50% or greater in cross-sectional tracheal luminal area at end-expiration. " 10/12/1998 - "The marked luminal narrowing, tracheomalacia, and temporal proximity of extubation to demise support tracheal collapse as a major contributor to the death in AO1. " 10/01/2009 - "In four patients, the percentages of luminal narrowing were 63.4% and 51.2%, respectively for tracheomalacia and 59.2% and 62.0%, respectively, for bronchomalacia. "
6.	SiliconesIBA 10/01/2012 - "External tracheal stabilization technique for acquired tracheomalacia using a tailored silicone tube." 09/01/1996 - "We present 5 patients with tracheostenosis or tracheomalacia managed with nine procedures of long silicone Montgomery T-tube prothesis between 1984 and 1994 in VGH-Taipei. " 09/01/1996 - "Use of the silicone tracheal T-tube for tracheostenosis or tracheomalacia." 06/01/2014 - "Therefore, we report a case of diffused PTA with tracheomalacia causing severe cartilage destruction, which is being successfully managed with bronchoscopic interventions and silicone stent placements. " 04/01/1995 - "[The use of a silicone T tube for the treatment of a case of American mucocutaneous leishmaniasis with tracheomalacia]."
7.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 01/01/2012 - "The most frequent association was with oesophageal atresia (44%), vascular ring or large vessel anomalies (18%) and innominate artery compression (16%); in 9% tracheomalacia was idiopathic. " 12/01/2002 - "Tracheomalacia with anterior great vessel compression is a common disorder in infants and children, which can lead to life-threatening airway occlusion. " 06/01/1986 - "The secondary group consisted of patients with tracheal compression due to great vessel abnormalities, or tracheostomy-tracheomalacia. " 07/01/1978 - "These functionnal troubles may be produced by different other anomalies: oesophageal stenosis and or dyskinesia often observed, gastro-oesophageal reflux, associated anomalies of the larynx or trachea; laryngeal paralysis, tracheomalacia, tracheal epithelium metaplasia, tracheal compression by abnormal vessel, neurological dysmaturity, loss of swallowing reflex after a long postoperative course. "
8.	Polypropylenes (Polypropylene)IBA 10/01/1990 - "We first made models of tracheomalacia by making fractures or resections in intrathoracic tracheal cartilages and then made an external fixation of Marlex mesh on the malacic segments of the trachea. " 11/01/1996 - "The authors describe the case of a 12-year-old boy who had a Marlex mesh splint placed because of life-threatening primary tracheomalacia at 6 months of age. " 11/01/1996 - "Intratracheal granuloma formation: a late complication of Marlex mesh splinting for tracheomalacia." 10/01/1982 - "A silastic reinforced marlex mesh splint was inserted surgically to support a collapsing airway in 3 children with tracheomalacia and 1 with bronchomalacia. "
9.	DexmedetomidineFDA Link 02/01/2010 - "The successful use of Dexmedetomidine as the main anesthetic agent for three pediatric patients with tracheomalacia presenting for different kinds of urgent operations is described. " 02/01/2010 - "Use of dexmedetomidine as the main anesthetic agent in patients with laryngo-tracheomalacia--a case report." 01/01/2011 - "Sudden Tracheal Collapse during EGD and Subsequent Anesthetic Management with Dexmedetomidine-Ketamine in a Patient with Achalasia and Tracheomalacia."
10.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 02/01/2004 - "Tracheomalacia was observed in the control and gelatin sponge groups but not in the bone morphogenetic protein group. " 01/01/2003 - "We investigated whether saber sheath-type tracheomalacia could be treated by the slow release of bone morphogenetic protein (BMP)-2 from a gelatin sponge. "

Therapies and Procedures

1.	Stents 04/01/1996 - "A wire stent was used successfully to treat life-threatening tracheomalacia in a 5-year-old girl. " 01/01/2013 - "Aortopexy and Stents are effective in relieving tracheomalacia in the latter patients. " 02/01/2015 - "Posterior tracheomalacia was successfully treated in selected cases, avoiding stent placement." 01/01/2015 - "Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle - a perspective on a new tool to avoid stent migration of Dumon stents." 01/01/2013 - "The Use of T-tube Cholangiocatheter Stents in the Treatment of Pediatric Tracheomalacia."
2.	Tracheostomy 01/01/1996 - "In the ITS group three patients died, two required Montgomery tracheostomy tubes for tracheomalacia, seven are receiving regular ELT and six are disease free at the time of writing. " 03/01/2015 - "During the follow-up (median duration of 17 months; range, 2-77 months), 13 (72%) patients were symptom-free and 2 (11%) underwent tracheostomy for tracheomalacia. " 09/01/2014 - "Following balloon tracheoplasty, two patients were extubated, one was extubated after resection and end-to-end anastomosis following initial balloon dilatation, and one remained hospitalized with tracheostomy for tracheomalacia. " 06/01/2012 - "Eleven patients required tracheostomy because of postoperative tracheomalacia confirmed by postoperative bronchoscopy in group A vs none in group B (P = .029). " 10/01/2009 - "One patient required a tracheostomy because of tracheomalacia. "
3.	Transplants (Transplant) 10/01/2007 - "The purpose of this study was to examine the efficiency of surgical treatment in patients with segmentary tracheomalacia using external ceramic ring grafts. " 06/01/1987 - "This study shows that experimentally induced tracheomalacia can be treated successfully by the application of an autologous periosteal tibial graft, which becomes incorporated into the weakened tracheal wall." 03/01/2011 - "The surgical strategy for acquired tracheomalacia due to innominate artery compression of the trachea involved superior mediastinal exposure, external reinforcement with autologous cartilage graft, anterior sling of the innominate artery with a muscle sling, and tracheopexy. " 10/01/2000 - "One child required CPAP for 4 months for residual tracheomalacia and a further child, who had 3 operations to insert 11 costal cartilage ring grafts, underwent ventilation intermittently for 6 months. " 10/01/2000 - "Between 1978 and 1999 at Sheffield Children's Hospital and The Royal Manchester Children's Hospital, of 16 children with clinically significant symptoms of tracheomalacia 8 underwent combined aortopexy and tracheopexy, 1 had aortopexy alone, 4 only had a tracheopexy, and 3 had tracheal reinforcement with free costal cartilage ring grafts. "
4.	Thyroidectomy 09/01/2011 - "In the present study we describe the use of NPPV in the management of respiratory distress in patients with post-thyroidectomy tracheomalacia. " 04/01/2012 - "Similarly, they are of concern to the anesthesiologists because of anticipated intubation-related difficulties and post-thyroidectomy tracheomalacia. " 10/01/2011 - "Tracheomalacia after thyroidectomy is a life-threatening situation. " 09/01/2011 - "A total of nine patients (1.5 %) were diagnosed with post-thyroidectomy tracheomalacia, five intraoperatively and four postoperatively. " 09/01/2011 - "Post-thyroidectomy tracheomalacia is a rare but complicated problem. "
5.	Tracheotomy 05/01/2015 - "Complications associated with long-term tracheotomy are obstruction of the distal end of the tube by granulation tissue and tracheomalacia. " 02/01/2014 - "[Acute respiratory failures caused by post-tracheotomy tracheomalacia]." 05/01/2013 - "Tracheotomy was performed on the other 2 cases complicated with tracheomalacia. " 01/01/2012 - "In the Goldenhar's syndrome case (2 years old) a Montgomery device was necessary for 6 months due to the presence of tracheotomy-inducted tracheomalacia. " 04/01/2007 - "Symptoms were due to stasis of secretions with associated pulmonary soiling in three children, severe tracheomalacia in six children, and respiratory obstruction related to the tip of a tracheotomy tube or endotracheal tube being displaced intermittently into the pouch in six children. "