Tracheobronchomalacia

A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the TRACHEA and the BRONCHI. This results in a floppy non-rigid airway making patency difficult to maintain.

Also Known As:

Networked: 85 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Airway Obstruction (Choking)
2.	Vocal Cord Paralysis
3.	Intrinsic Positive-Pressure Respiration
4.	Pulmonary Atelectasis
5.	Pathologic Constriction (Stenosis)

Experts

1.	Majid, Adnan: 6 articles (01/2016 - 08/2007)
2.	Folch, Erik: 4 articles (01/2016 - 06/2014)
3.	Feller-Kopman, David: 4 articles (11/2012 - 08/2007)
4.	Gangadharan, Sidhu P: 3 articles (01/2016 - 06/2014)
5.	Ernst, Armin: 3 articles (07/2014 - 08/2007)
6.	Kent, Michael S: 2 articles (01/2016 - 06/2014)
7.	Cheng, George Z: 2 articles (07/2015 - 06/2014)
8.	Yarmus, Lonny: 2 articles (11/2012 - 07/2012)
9.	Mehta, Atul C: 2 articles (03/2010 - 11/2006)
10.	Gangadharan, Sidhu: 2 articles (10/2008 - 08/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tracheobronchomalacia:

1.	Phenobarbital (Luminal)FDA Link 07/01/2014 - "Dynamic flexible bronchoscopy is the "gold standard" for assessing changes in airway luminal size associated with tracheobronchomalacia, but the procedure has not been adequately validated. " 12/01/2013 - "He received ICU care for 30 days, and now, he was on supportive care on a ward, considering Y stent insertion to prevent luminal collapse from tracheobronchomalacia. " 08/01/2014 - "General anesthesia was successfully performed in an 86-year-old woman with severe tracheobronchomalacia Tracheobronchomalacia in adult is a very rare disease, characterized by weakness of the trachea and bronchi, causing luminal narrowing during expiration. "
2.	sevoflurane (Ultane)FDA LinkGeneric 02/01/2005 - "Sedation using sevoflurane may be helpful in maintaining airway patency in the pediatric patient with tracheobronchomalacia." 02/01/2005 - "[Severe airway obstruction relieved by sedation using sevoflurane in a pediatric patient with tracheobronchomalacia]."
3.	SiliconesIBA 08/01/2007 - "Airway stabilization with silicone stents for treating adult tracheobronchomalacia: a prospective observational study." 10/01/2008 - "Central airway stabilization with silicone stents can improve respiratory symptoms in patients with severe symptomatic tracheobronchomalacia (TBM) but is associated with a relatively high rate of complications. "
4.	Tracheal agenesisIBA 04/01/2001 - "Diagnoses were: syndrome-associated tracheobronchomalacia (n = 4), malignancy infiltrating the carina (n = 1), congenital tracheal stenosis (n = 1), and tracheobronchial compression by a malpositioned aorta (n = 1). " 03/01/2015 - "Etiology of the airway obstruction included congenital tracheal stenosis (n = 4), giant cervical and superior mediastinal lymphatic malformation with tracheobronchomalacia (n = 1). " 10/01/2009 - "Slide tracheoplasty does not affect the carina during long-segment congenital tracheal stenosis management, and thus lesions of the carina, such as stenosis and tracheobronchomalacia can become important causes of extubation failure after surgery. "
5.	1- ethyl- 3- (3- dimethylaminoethyl)carbodiimide (EDAC)IBA 01/01/2013 - "Tracheobronchomalacia (TBM) is a pathologic condition in which softening of tracheal and bronchial cartilage causes the dynamic narrowing of transverse or sagittal diameters of tracheobronchial lumen; an excessive dynamic airway collapse (EDAC) may also be associated, with a substantial invagination of the posterior membrane of trachebronchial tree.The" 07/01/2011 - "The prevalence of tracheobronchomalacia and EDAC depends upon the patient population, associated comorbidities and underlying aetiologies, diagnostic tools used and criteria used to define the airway collapse. " 01/01/2006 - "Tracheobronchomalacia (TBM) and excessive dynamic airway collapse (EDAC) are both dynamic forms of central airway obstruction characterized by a decrease of >/=50% in the cross-sectional area of the tracheobronchial lumen. "
6.	Matrix MetalloproteinasesIBA 03/01/1994 - "[Localization of matrix metalloproteinases in tracheobronchomalacia: preliminary report]."
7.	Nonsense Codon (Nonsense Mutation)IBA 01/01/2011 - "Here, we report on a male patient aged 6 years presenting with a mosaic nonsense mutation c.994delG within the FLNA gene, PH and severe congenital lung disease comprising bilateral atelectasis, lung cysts, tracheobronchomalacia, pulmonary arterial hypertension and long-term oxygen dependence; histology of resected lung showed panpulmonary emphysema with marked reduction of bronchial cartilage. "
8.	Urea (Carbamide)FDA LinkGeneric 11/01/2006 - "Urea nitrogen value, nitric oxide treatment, delayed sternal closure, and tracheobronchomalacia, measured at the same point of time, were independent predictors of LMV. " 11/01/2006 - "Of all the studied clinical predictors, MMV was associated with pulmonary hypertensive events, delayed sternal closure, peritoneal dialysis, nonvascular pulmonary problems, low output syndrome and fluid intake, while urea nitrogen (24 h), postsurgical neurological events, nitric oxide, tracheobronchomalacia, pulmonary hypertensive events and cardiac reoperations were identified as determinants of LMV. "
9.	TitaniumIBA 11/01/1994 - "To develop a new prosthesis for treating tracheal stenosis and tracheobronchomalacia, we examined the usefulness of an intratracheal stent made of shape memory alloy (SMA), a titanium-nickel alloy composed of 50% of each metal. "
10.	Polytetrafluoroethylene (Teflon)FDA Link 11/01/2013 - "Since 2003, we have performed external stabilization for severe tracheobronchomalacia using separated ring-reinforced expanded polytetrafluoroethylene (ePTFE) grafts. "

Therapies and Procedures

1.	Continuous Positive Airway Pressure 11/01/1994 - "Continuous positive airway pressure (CPAP) has been used in the treatment of infants with tracheobronchomalacia (TBM). " 06/01/1994 - "Management of severe congenital tracheobronchomalacia by continuous positive airway pressure and tidal breathing flow-volume loop analysis." 02/01/1993 - "The effect of nasal continuous positive airway pressure (CPAP) was assessed in three patients with tracheobronchomalacia (TBM) who failed conventional medical management. " 02/01/1993 - "Nasal continuous positive airway pressure in the treatment of tracheobronchomalacia." 08/01/1990 - "Treatment of an infant with tracheobronchomalacia at home with a lightweight, high-humidity, continuous positive airway pressure system."
2.	Positive-Pressure Respiration (PEEP) 04/01/1986 - "Tracheobronchomalacia may be more frequent than usually appreciated; the treatment of choice appears to be long-term PEEP." 03/01/2015 - "Tracheobronchomalacia in a patient on invasive mechanical ventilation: the role of electrical impedance tomography in its detection and positive end-expiratory pressure titration." 03/01/1999 - "It may provide an attractive alternative therapy to prolonged mechanical ventilation with positive end expiratory pressure in patients with severe tracheobronchomalacia. " 11/01/1997 - "With this type of stent we treated a patient with acquired saber-sheath type tracheobronchomalacia (TBM), Rayl's type II, Johnson's grade III, whose condition was aggravated even under positive end expiratory pressure (PEEP) therapy. " 10/01/2001 - "Mobile CT scanners may be useful in radiographically determining the optimal level of PEEP in infants with tracheobronchomalacia and bronchopulmonary dysplasia."
3.	Transplants (Transplant) 11/01/2013 - "External stabilization for severe tracheobronchomalacia using separated ring-reinforced ePTFE grafts is effective and safe on a long-term basis." 11/01/2013 - "External stabilization with separated ring-reinforced ePTFE grafts for severe tracheobronchomalacia is effective, less invasive than alternatives and preserves the growth potential of the affected airway segment." 11/01/2001 - "Pectus excavatum repair using a costal cartilage graft for patients with tracheobronchomalacia." 07/01/2006 - "Causes of airway stenosis included transplant stricture (n = 13), tracheal tube injury (n = 10), inflammation (n = 6), tracheobronchomalacia (n = 4), infection (n = 3), and extrinsic compression (n = 4). " 11/01/2013 - "Since 2003, we have performed external stabilization for severe tracheobronchomalacia using separated ring-reinforced expanded polytetrafluoroethylene (ePTFE) grafts. "
4.	Stents 07/01/2015 - "Use of Self-expanding Metallic Airway Stents in Tracheobronchomalacia." 01/01/2014 - "Insertion of a tracheobronchial stent was necessary due to severe tracheobronchomalacia. " 07/01/2012 - "Endobronchial stents have been used occasionally to treat benign conditions such as tracheobronchomalacia (TBM). " 07/01/2012 - "Dynamic Y stent fractures in crescentic tracheobronchomalacia." 03/01/2009 - "One child needed plication of paralyzed right hemi-diaphragm and another distal tracheal Palmaz stent insertion due severe tracheobronchomalacia. "
5.	General Anesthesia 08/01/2014 - "We gave general anesthesia satisfactorily in a patient with tracheobronchomalacia." 08/01/2014 - "In this case, no special care such as postoperative CPAP was necessary, but normally, general anesthesia for a patient with tracheobronchomalacia requires attention. " 10/01/2006 - "Tracheobronchomalacia-like lung collapse during three separate trials of general anesthesia." 08/01/2014 - "General anesthesia was successfully performed in an 86-year-old woman with severe tracheobronchomalacia Tracheobronchomalacia in adult is a very rare disease, characterized by weakness of the trachea and bronchi, causing luminal narrowing during expiration. "