Osteochondrosis (Osgood Schlatter Disease)

Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).

Also Known As:

Networked: 342 relevant articles (14 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neurologic Manifestations (Neurological Manifestations)
2.	Tendinopathy (Tendonitis)
3.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
4.	Pain (Aches)
5.	Intra-Articular Fractures

Experts

1.	van Weeren, P R: 4 articles (12/2011 - 02/2000)
2.	Serteyn, D: 3 articles (11/2011 - 02/2007)
3.	Distl, O: 3 articles (11/2009 - 01/2006)
4.	Grace, N D: 3 articles (12/2005 - 08/2001)
5.	Nixon, Alan J: 3 articles (09/2005 - 11/2002)
6.	Semevolos, Stacy A: 3 articles (09/2005 - 11/2002)
7.	Serteyn, Didier: 2 articles (01/2015 - 10/2011)
8.	Khizhniak, M V: 2 articles (03/2013 - 01/2001)
9.	Lepage, O: 2 articles (12/2011 - 05/2008)
10.	Donabédian, M: 2 articles (12/2011 - 05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteochondrosis:

1.	CalciumIBA 01/01/1991 - "Osteochondrosis in fetuses of ewes overfed calcium." 12/02/2000 - "The dogs fed the high calcium and phosphorus diet became slightly hypophosphataemic, their growth was retarded, and they had disturbances in skeletal development resembling osteochondrosis, which had only partly resolved after 10 weeks on the normal calcium and phosphorus diet." 09/01/1983 - "[Effect of calcium and phosphorus supply on osteochondrosis in fattening swine]." 07/14/1990 - "Growth cartilages with dyschondroplastic foci (osteochondrosis) or areas of chondrolysis were selected from the ribs and bones of the appendicular skeleton of 132 commercial pigs euthanased between one and 169 days old or at a liveweight of 100 kg. Histochemical staining techniques that identified proteoglycans, collagen and deposits of calcium enhanced the visualisation of the lesions, were valuable for recognising the distribution of lesions, and helped to elucidate the development of the lesions. " 11/01/1995 - "Considerable changes of collagen, glycosaminoglycans and calcium were observed both in vertebral tissues, bone, and in the heart, vessels, liver during development of "experimental osteochondrosis". "
2.	Insulin-Like Growth Factor I (IGF-1)IBA 07/01/2001 - "Cartilage obtained from osteochondrosis lesions had significantly greater expression of IGF-I, compared with normal cartilage. " 10/01/2009 - "This result may still reflect an earlier imbalance in IGF-I levels from horses with developmental osteochondral lesions considering the aetiopathological link which has been made between IGF-I and the occurrence of osteochondrosis. " 11/01/1999 - "Osteochondrosis-positive foals showed a significantly lower IGF-I activity than osteochondrosis-negative foals. " 10/01/1992 - "Increased concentrations of IGF-I, T3 and T4 could be causally related to osteochondrosis, which frequently occurs in intensively fed dogs." 05/01/1995 - "Porcine osteochondrosis: deficiencies in transforming growth factor-beta and insulin-like growth factor-I."
3.	hydroxide ionIBA 11/29/2002 - "Large-breed pups fed on a standard diet supplemented with Ca and P had decreased plasma concentrations of both 25(OH)D(3) and 1,25(OH)(2)D(3), which may indicate an increased clearance of these metabolites; the low plasma concentrations of the di-hydroxylated vitamin D metabolites were considered responsible for the disturbance in cartilage maturation (i.e., osteochondrosis) in these dogs. " 06/01/2003 - "It is suggested that in GD, increased calcitonin levels and/or a relative deficiency in 24,25(OH)2D3 at the growth-plate level may both be responsible for the retarded maturation of chondrocytes, resulting in retained cartilage cones and osteochondrosis, and this may be a pathophysiological factor for the increased susceptibility of large breed dogs to developing skeletal disorders." 01/01/1989 - "The incidence of osteochondrosis at 2 weeks was, respectively, 0/8, 0/8, 0/8, 0/8, 0/8, and 1/8, and at 4 weeks was, respectively, 0/8, 0/8, 0/8, 2/8, 2/8 and 2/8. The NRC (1988) estimate of the requirement for vitamin D may be somewhat low since the concentration of plasma 25(OH)D was lower with 200 or 1,000 IU vitamin D/kg diet than at the start." 11/01/1999 - "PTH, 1,25(OH)2D, cortisol, copper, zinc and calcium also showed significant differences between osteochondrosis-positive and osteochondrosis-negative foals." 11/01/1999 - "The present study focused on a possible relationship between insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D (1,25(OH)2D), cortisol, copper, zinc, calcium, ionised calcium, magnesium and phosphorus and 5 different postmortem and radiographical osteochondrosis scores of hock and stifle joints in foals age 0-11 months. "
4.	Propranolol (Inderal)FDA LinkGeneric 03/01/1989 - "The study performed by the authors into the effect of low-frequency magnetic field on coronary heart disease, cervical and thoracic osteochondrosis arising in senile and presenile patients showed the treatment to promote improvement of the heart autonomic regulation and attenuation of ischemic and vertebrogenic pain, to augment response to antiarrhythmic treatment in coronary patients with extrasystoles, to compensate for negatively inotropic effect of propranolol hydrochloride, to increase exercise tolerance." 10/01/1991 - "The efficacy of drug (inderal, corinfar) treatment in combination with manual therapy (the course was 4-7 sessions) was examined in hypertensives with cervical osteochondrosis. "
5.	CollagenIBA 12/01/2014 - "Treatment of focal cartilage defects (traumatic or osteochondrosis dissecans) of the talus using a collagen matrix. " 01/01/1994 - "Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis." 01/01/1986 - "We conclude that a disturbance of collagen or ground substance biosynthesis is of importance in the pathogenesis of juvenile osteochondrosis." 01/01/1986 - "In osteochondrosis juvenilis Scheuermann, foci of various sizes in the cartilaginous end plates of the vertebral bodies display a loosening or complete interruption of the collagen fibers. " 01/01/1974 - "[The lymphocyte blast-transformation reaction under the influence of collagen in osteochondrosis patients with a radicular syndrome]."
6.	PapainIBA 09/01/1980 - "The use of Soviet papain makes possible effective treatment of patients suffering from lumbar osteochondrosis." 11/01/1985 - "Twenty-nine patients with cervical osteochondrosis and reflex syndromes were treated by the method of disc puncture using the proteolytic enzyme papain in complex with dereception. " 11/01/1985 - "[Use of the proteolytic enzyme papain in the treatment of cervical osteochondrosis]." 08/01/1984 - "[Clinico-electromyographic parallels in the evaluation of the results of treating lumbar osteochondrosis by the papain nucleolysis technic]." 10/01/1980 - "[Biochemical mechanisms of the action of papain on the connective tissue of the intervertebral disks in osteochondrosis]."
7.	Vitamin DFDA LinkGeneric 11/29/2002 - "Large-breed pups fed on a standard diet supplemented with Ca and P had decreased plasma concentrations of both 25(OH)D(3) and 1,25(OH)(2)D(3), which may indicate an increased clearance of these metabolites; the low plasma concentrations of the di-hydroxylated vitamin D metabolites were considered responsible for the disturbance in cartilage maturation (i.e., osteochondrosis) in these dogs. " 01/01/1989 - "The incidence of osteochondrosis at 2 weeks was, respectively, 0/8, 0/8, 0/8, 0/8, 0/8, and 1/8, and at 4 weeks was, respectively, 0/8, 0/8, 0/8, 2/8, 2/8 and 2/8. The NRC (1988) estimate of the requirement for vitamin D may be somewhat low since the concentration of plasma 25(OH)D was lower with 200 or 1,000 IU vitamin D/kg diet than at the start." 01/01/1978 - "Effects of vitamin D and A, calcium, phosphorus, and protein on frequency and severity of osteochondrosis in pigs."
8.	Proteoglycans (Proteoglycan)IBA 11/01/2005 - "Comparison of proteoglycan and collagen in articular cartilage of horses with naturally developing osteochondrosis and healing osteochondral fragments of experimentally induced fractures." 07/14/1990 - "Growth cartilages with dyschondroplastic foci (osteochondrosis) or areas of chondrolysis were selected from the ribs and bones of the appendicular skeleton of 132 commercial pigs euthanased between one and 169 days old or at a liveweight of 100 kg. Histochemical staining techniques that identified proteoglycans, collagen and deposits of calcium enhanced the visualisation of the lesions, were valuable for recognising the distribution of lesions, and helped to elucidate the development of the lesions. " 05/01/2000 - "We used immunoassays that measure a keratan sulfate epitope and the epitope 846 on the cartilage proteoglycan aggrecan and the C-propeptide of cartilage type-II procollagen, which is released following the synthesis of this molecule, to analyse synovial fluids from equine tarsocrural joints with and without osteochondrosis. "
9.	Carbon MonoxideIBA 03/01/1995 - "The authors' experience in the use of interference currents (IC) in postapoplectic (PA) and cervical osteochondrosis (CO) patients led them to the following conclusions: a course of IC treatment (dynamic field) brings the response in 62-70% of PA patients, but a complete response is not reached because of the disease severity; in CO patients the response is achieved in 86% of patients; a single IC procedure entails a significant reduction in heart rate; IC course in CO patients increases blood filling of brachial vessels and decreases vascular tone on the affected side; IC course in PA patients significantly increases blood filling and reduces vascular tone in the vessels on both affected and unaffected sides; single and course IC improves hemodynamics in the external carotid arteries and normalizes venous outflow in the region of vertebral and external carotid arteries in 1/3 of PA patients; in CA patients cerebral circulation improves in 90%. " 12/01/2008 - "Co-morbidities included three patients with concurrent Osgood-Schlatter disease and one with osteogenesis imperfecta. "
10.	Nifedipine (Adalat)FDA LinkGeneric 10/01/1991 - "The efficacy of drug (inderal, corinfar) treatment in combination with manual therapy (the course was 4-7 sessions) was examined in hypertensives with cervical osteochondrosis. "

Therapies and Procedures

1.	Osteotomy 01/01/2006 - "We report a case of genu recurvatum secondary to Osgood-Schlatter disease treated successfully with proximal tibial osteotomy and distraction with a Taylor spatial frame." 07/01/1996 - "[Postoperative evaluation of osteochondrosis dissecans of the talus with special reference to medial malleolar osteotomy]." 12/01/1969 - "[Osteotomy for directional and biological purposes in osteochondrosis in childhood]." 09/01/1969 - "[Centering osteotomy in the treatment of post-reduction osteochondrosis of the hip]." 07/01/1967 - "[Centration osteotomy in osteochondrosis of the hip]."
2.	Lasers (Laser) 01/01/2002 - "[Mechanisms of therapeutic efficacy of magnetic laser irradiation of patients with neurological symptoms of lumbar osteochondrosis]." 10/01/2004 - "[Laser puncture in the treatment of reflectory manifestations of lumbosacral osteochondrosis in elderly patients in geriatric hospital]." 07/01/2000 - "The use of osteoperiosteal electropuncture and laser puncture combined in a complex treatment of 162 patients with lumbosacral osteochondrosis resulted in dissipation or apparent decrement in clinical manifestations of the trouble. " 01/01/2009 - "The results of surgical treatment of 185 patients with osteochondrosis of the vertebral column were studied during 12 months who, after complex clinico-radial examination, were treated by puncture laser nucleoplasty of intervertebral disks using a diode laser. " 01/01/2001 - "[Percutaneous laser diskectomy in cervical osteochondrosis]."
3.	Injections 01/01/2015 - "The results of this review found limited evidence that prolotherapy injections are a safe and effective treatment for Achilles tendinopathy, plantar fasciopathy and Osgood-Schlatter disease, however more robust research using large, methodologically-sound randomised controlled trials is required to substantiate these findings." 01/01/2015 - "These were then grouped according to tendinopathy or fasciopathy being treated with prolotherapy injections: Achilles tendinopathy, plantar fasciopathy and Osgood-Schlatter disease. " 06/01/1988 - "[Treatment of reflex neurodystrophic syndromes of lumbar osteochondrosis using hydroxycobalamin injections]." 01/01/2015 - "The analysis also suggests prolotherapy injections provide equal or superior short-, intermediate- and long-term results to alternative treatment modalities, including eccentric loading exercises forAchilles tendinopathy, platelet-rich plasma for plantar fasciopathy and usual care or lignocaine injections for Osgood-Schlatter disease. "
4.	Musculoskeletal Manipulations (Manipulative Therapy) 01/01/2002 - "[The influence of vegetative status of patients with neurological signs of cervical osteochondrosis on manual therapy efficacy]." 09/01/1995 - "Experience is reported of treatment of patients presenting with reflex lumbar osteochondrosis syndromes (n = 136) by manual therapy and acupuncture. " 07/01/1994 - "The authors studied the time course of spontaneous nystagmus and parameters of vestibuloocular interaction in patients with reflex syndromes of cervical osteochondrosis accompanied by vestibular dysfunction, under the influence of manual therapy. " 10/01/1992 - "[The complications of manual therapy in osteochondrosis of the cervical spine]." 10/01/1991 - "[Effect of manual therapy on blood pressure in hypertensives with cervical osteochondrosis]."
5.	Surgical Casts (Plaster Cast) 07/01/1983 - "The disease is a physeal osteochondrosis and conservative treatment with serial corrective plaster casts is as effective as corrective osteotomies."