Idiopathic Interstitial Pneumonias

A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.

Also Known As:

Networked: 202 relevant articles (11 outcomes, 20 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sarcoidosis (Schaumann Disease)
2.	Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis)
3.	Connective Tissue Diseases (Connective Tissue Disease)
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
5.	Interstitial Lung Diseases (Interstitial Lung Disease)

Experts

1.	Chida, Kingo: 6 articles (11/2011 - 11/2004)
2.	Colby, Thomas V: 5 articles (12/2015 - 01/2003)
3.	Date, Hiroshi: 5 articles (12/2011 - 08/2003)
4.	Suda, Takafumi: 5 articles (11/2011 - 01/2006)
5.	Inui, Naoki: 4 articles (11/2011 - 01/2008)
6.	Enomoto, Noriyuki: 4 articles (08/2009 - 11/2004)
7.	Antoniou, Katerina M: 3 articles (01/2016 - 04/2010)
8.	Inoue, Yoshikazu: 3 articles (12/2015 - 04/2007)
9.	Karagiannis, Konstantinos: 3 articles (09/2014 - 04/2010)
10.	Azuma, Arata: 3 articles (01/2014 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Idiopathic Interstitial Pneumonias:

1.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 02/01/2013 - "The addition of co-trimoxazole therapy to standard treatment for fibrotic idiopathic interstitial pneumonia had no effect on lung function but resulted in improved quality of life and a reduction in mortality in those adhering to treatment. " 01/01/2014 - "We report an economic evaluation alongside a multi-centre, randomised, placebo-controlled, double-blind trial of 12 months therapy with 960 mg co-trimoxazole daily in 181 patients with fibrotic idiopathic interstitial pneumonia (IIP). " 02/01/2013 - "In a double-blind multicentre study, 181 patients with fibrotic idiopathic interstitial pneumonia (89% diagnosed as definite/probable IPF) were randomised to receive co-trimoxazole 960 mg twice daily or placebo for 12 months in addition to usual care. "
2.	Polymyxin B (Aerosporin)FDA LinkGeneric 05/01/2015 - "[CLINICAL EFFICACY OF SUSTAINED HIGH-EFFICACY DAILY DIAFILTRATION USING A MEDIATOR-ADSORBING MEMBRANE AND DIRECT HEMOPERFUSION WITH A POLYMYXIN B-IMMOBILIZED FIBER COLUMN IN TREATING ACUTE EXACERBATION OF IDIOPATHIC INTERSTITIAL PNEUMONIAS]." 05/01/2015 - "The aim of this study is to investigate the clinical outcomes of patients with steroid-resistant acute exacerbation of idiopathic interstitial pneumonias treated with blood purification therapy comprising direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP) and sustained high-efficacy daily diafiltration using a mediator-adsorbing membrane (SHEDD-fA). "
3.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/01/2001 - "[A case of idiopathic interstitial pneumonia that responded well to intermittent intravenous administration of high doses of cyclophosphamide and a steroid]." 10/01/2001 - "A 75-year-old man who had received a diagnosis of idiopathic interstitial pneumonia had been followed in our hospital since 1995, and had been treated with cyclophosphamide since September 1999. " 10/01/1994 - "[Idiopathic interstitial pneumonia that responded to intermittent intravenous administration of high-dose cyclophosphamide]." 01/01/1986 - "Development of early cytomegalovirus (CMV) or idiopathic interstitial pneumonia was infrequent in patients with aplastic anemia prepared only with cyclophosphamide. " 11/01/2004 - "[A case of subacute idiopathic interstitial pneumonia resistant to steroids, successfully treated with cyclophosphamide]."
4.	Carboplatin (JM8)FDA LinkGeneric 01/01/2011 - "The safety and efficacy of weekly paclitaxel in combination with carboplatin for advanced non-small cell lung cancer with idiopathic interstitial pneumonias." 04/01/2011 - "The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias."
5.	SodiumIBA 10/01/2007 - "We consider that sodium siverlestat is effective for fulminant idiopathic interstitial pneumonia." 10/01/2007 - "A patient with fulminant idiopathic interstitial pneumonia was treated by sodium siverlestat and steroid pulse therapy following extracorporeal lung assist (ECLA). " 10/01/2007 - "[Case of fulminant idiopathic interstitial pneumonia treated by sodium siverlestat (Elaspol) and steroid pulse therapy following extracorporeal lung assist (ECLA)]." 01/01/2006 - "Therefore, sivelestat sodium hydrate may be one of the treatment options for acute respiratory failure due to idiopathic interstitial pneumonia." 01/01/2006 - "[Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy]."
6.	Chymases (Chymase)IBA 04/01/2007 - "We studied the roles of mast cell chymase in the fibritic processes of human idiopathic interstitial pneumonias. " 04/01/2007 - "Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia." 04/01/2007 - "Because smooth muscle cell and myofibroblast proliferation is a principal pathological change in idiopathic interstitial pneumonias, these observations suggest that mast cell chymase, possibly induced by interleukin-4-dependent phenotypic modulation, may be an important mediator in the inflammatory and fibrotic processes of idiopathic interstitial pneumonia in humans." 04/01/2007 - "The numbers of both tryptase-positive mast cells and chymase-positive mast cells were significantly greater in lung tissues with idiopathic interstitial pneumonia than in normal lung tissues. "
7.	Tryptases (Tryptase)IBA 04/01/2007 - "The numbers of both tryptase-positive mast cells and chymase-positive mast cells were significantly greater in lung tissues with idiopathic interstitial pneumonia than in normal lung tissues. "
8.	Secretory Proteinase Inhibitory ProteinsIBA 09/01/1999 - "Neutrophil elastase inhibitors become very useful therapeutic agents against acute exacerbation of idiopathic interstitial pneumonia (IIP), because this pathological conditions is a type of ALI. "
9.	Paclitaxel (Taxol)FDA LinkGeneric 01/01/2011 - "The safety and efficacy of weekly paclitaxel in combination with carboplatin for advanced non-small cell lung cancer with idiopathic interstitial pneumonias."
10.	Cyclosporine (Ciclosporin)FDA LinkGeneric 04/01/2001 - "[Successful therapy of cyclosporin A in a case with idiopathic interstitial pneumonia]." 04/01/2001 - "It suggests that cyclosporin A may be useful for the treatment of idiopathic interstitial pneumonia."

Therapies and Procedures

1.	Lung Transplantation 12/01/1999 - "The physical status of the patient with idiopathic interstitial pneumonia was markedly improved after pulmonary rehabilitation, and she did not need to undergo lung transplantation. " 12/01/2011 - "A 6-year-old girl with idiopathic interstitial pneumonia successfully underwent living-donor right single-lobe lung transplantation from her mother. " 09/01/2005 - "Among patients awaiting cadaveric lung transplantation, patients with idiopathic interstitial pneumonia (IIP) have been demonstrated to have the highest mortality rate. " 09/01/2005 - "A new treatment strategy for advanced idiopathic interstitial pneumonia: living-donor lobar lung transplantation." 09/01/2002 - "Predicting survival of lung transplantation candidates with idiopathic interstitial pneumonia: does PaO(2) predict survival?"
2.	Hemoperfusion 05/01/2015 - "[CLINICAL EFFICACY OF SUSTAINED HIGH-EFFICACY DAILY DIAFILTRATION USING A MEDIATOR-ADSORBING MEMBRANE AND DIRECT HEMOPERFUSION WITH A POLYMYXIN B-IMMOBILIZED FIBER COLUMN IN TREATING ACUTE EXACERBATION OF IDIOPATHIC INTERSTITIAL PNEUMONIAS]." 05/01/2015 - "The aim of this study is to investigate the clinical outcomes of patients with steroid-resistant acute exacerbation of idiopathic interstitial pneumonias treated with blood purification therapy comprising direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP) and sustained high-efficacy daily diafiltration using a mediator-adsorbing membrane (SHEDD-fA). "
3.	Aftercare (After-Treatment) 01/01/1997 - "We suggest that corticosteroid pulse treatment is effective in acute exacerbatins of idiopathic interstitial pneumonia and that effectiveness should be evaluated three months after treatment." 10/01/2005 - "[Acquired hemophilia developing after treatment of idiopathic interstitial pneumonia]."
4.	Transplants (Transplant) 09/01/2002 - "A retrospective review was performed of all lung transplant referrals for idiopathic interstitial pneumonia that were listed with United Network for Organ Sharing at the University of California San Diego from January 1990 to February 1999. " 01/01/1995 - "1 patient with multiple myeloma, who had received total body irradiation in combination with chemotherapy for the 2nd transplant, succumbed from idiopathic interstitial pneumonia. " 05/01/2009 - "The term late-onset non-infectious pulmonary complications (LONIPCs) has been used to refer to events occurring later than 3 months after allogeneic hematopoietic stem transplant (HSCT), such as bronchiolitis obliterans, bronchiolitis obliterans with organizing pneumonia, and lymphocytic or idiopathic interstitial pneumonia. " 04/01/2007 - "The pneumonias that are specifically related to allogenic transplant are idiopathic interstitial pneumonia, bronchiolitis obliterans, and bronchiolitis obliterans organizing pneumonia, which are all considered to be pulmonary manifestations of graft-versus-host disease, and treated as such. " 04/01/2009 - "Lower serum albumin is strongly and independently associated with higher mortality in patients with idiopathic interstitial pneumonia on transplant waiting lists."
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/01/1981 - "Idiopathic interstitial pneumonia following bone marrow transplantation: the relationship with total body irradiation." 07/01/1997 - "[Diffuse alveolar hemorrhage associated with idiopathic interstitial pneumonia syndrome after allogeneic bone marrow transplantation]." 06/01/1989 - "[Validity of immunohistology and in situ hybridization in the differential diagnosis of cytomegalovirus pneumonia and idiopathic interstitial pneumonia after allogenic bone marrow transplantation]." 02/01/1990 - "After bone marrow grafting, bacterial pneumonia, fungal pneumonia, bronchitis, mixed bacterial and fungal pneumonia, interstitial viral pneumonia, unclear pulmonary infiltrates, idiopathic interstitial pneumonia, pneumonia due to rare pathogens, obstructive bronchitis, and ARDS can occur. "