Postural Orthostatic Tachycardia Syndrome

A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.

Also Known As:

Networked: 131 relevant articles (16 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Vasovagal Syncope
2.	Tachycardia (Tachyarrhythmias)
3.	Orthostatic Hypotension (Postural Hypotension)
4.	Orthostatic Intolerance
5.	Syncope (Fainting)

Experts

1.	Du, Junbao: 20 articles (06/2015 - 01/2011)
2.	Biaggioni, Italo: 15 articles (12/2015 - 04/2005)
3.	Raj, Satish R: 15 articles (12/2015 - 04/2005)
4.	Jin, Hongfang: 15 articles (06/2015 - 01/2011)
5.	Robertson, David: 15 articles (06/2015 - 04/2005)
6.	Black, Bonnie K: 14 articles (12/2015 - 04/2005)
7.	Tang, Chaoshu: 13 articles (06/2015 - 01/2011)
8.	Stewart, Julian M: 13 articles (08/2014 - 12/2002)
9.	Medow, Marvin S: 12 articles (08/2014 - 10/2005)
10.	Paranjape, Sachin Y: 10 articles (06/2015 - 04/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Postural Orthostatic Tachycardia Syndrome:

1.	Midodrine (Midon)FDA LinkGeneric 01/01/2011 - "Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome." 09/01/2008 - "Selective alpha1 receptor agonist midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome." 04/01/2014 - "Difference between supine and upright blood pressure associates to the efficacy of midodrine on postural orthostatic tachycardia syndrome (POTS) in children." 09/15/2013 - "This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). " 09/01/2008 - "The study was designed to examine the effect of selective alpha1 receptor agonist midodrine hydrochloride in the treatment of children with postural orthostatic tachycardia syndrome. "
2.	ivabradineIBA 02/01/2014 - "Ivabradine, an I(f) current blocker, has shown promising results in treatment of postural orthostatic tachycardia syndrome (POTS). " 12/01/2007 - "Symptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradine." 01/01/2015 - "The Effect of Ivabradine on the Heart Rate and Sympathovagal Balance in Postural Tachycardia Syndrome Patients." 03/01/2011 - "Postural orthostatic tachycardia syndrome patients prescribed ivabradine were identified from the pharmacy database. " 03/01/2011 - "Single centre experience of ivabradine in postural orthostatic tachycardia syndrome."
3.	Pyridostigmine Bromide (Pyridostigmine)FDA LinkGeneric 11/01/2006 - "Pyridostigmine has been a safe and effective treatment modality for this child with postural orthostatic tachycardia syndrome. " 09/01/2014 - "Postural orthostatic tachycardia syndrome was diagnosed, and pyridostigmine treatment was started. " 09/01/2014 - "[Pyridostigmine in the treatment of postural orthostatic tachycardia syndrome]." 02/01/2007 - "When evaluated for postural tachycardia syndrome, pyridostigmine bromide significantly reduced standing heart rate (10%). " 11/01/2006 - "The patient with postural orthostatic tachycardia syndrome showed a dose-dependent favorable response to oral pyridostigmine. "
4.	Metoprolol (Lopressor)FDA LinkGeneric 08/15/2014 - "Metoprolol is clinically used to treat postural tachycardia syndrome (POTS) in children, but its effectiveness is unsatisfactory. " 08/15/2014 - "Usefulness of plasma copeptin as a biomarker to predict the therapeutic effectiveness of metoprolol for postural tachycardia syndrome in children." 01/01/2015 - "This study was designed to investigate predictive value of plasma C-type natriuretic peptide (CNP) in the therapeutic efficacy of metoprolol on postural tachycardia syndrome (POTS) in children. " 01/01/2011 - "The study was carried out to examine the effect of selective α1 adrenoceptor agonist midodrine hydrochloride vs. β-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS). " 01/01/2015 - "Plasma C-type natriuretic peptide as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome."
5.	AdrenomedullinIBA 07/24/2012 - "This study was designed to explore the predictive value of the midregional fragment of pro-adrenomedullin (MR-proADM) in assessing the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS). " 06/01/2015 - "To explore the predictive value of baseline plasma midregional fragment of pro-adrenomedullin level (MR-proADM) on long-term survival of postural tachycardia syndrome (POTS) children treated with midodrine hydrochloride. " 06/01/2015 - "[Predictive value of baseline plasma midregional fragment of pro-adrenomedullin level on long-term outcome of postural tachycardia syndrome children treated with midodrine hydrochloride]." 07/24/2012 - "Midregional pro-adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome."
6.	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 06/01/2015 - "Total peripheral vascular resistance, cardiac output, and plasma C-type natriuretic Peptide level in children with postural tachycardia syndrome." 01/01/2015 - "This study was designed to investigate predictive value of plasma C-type natriuretic peptide (CNP) in the therapeutic efficacy of metoprolol on postural tachycardia syndrome (POTS) in children. " 06/01/2015 - "To investigate the total peripheral vascular resistance (TPVR), cardiac output (CO), and plasma C-type natriuretic peptide (CNP) levels in children with postural tachycardia syndrome (POTS) during supine, upright, and return to supine. " 01/01/2015 - "Plasma C-type natriuretic peptide as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome."
7.	SaltsIBA 01/01/2015 - "[Evaluation of the changes in heart rate during head-up test predicting the efficacy of oral rehydration salts on postural tachycardia syndrome in children]." 01/01/2015 - "To predict the therapeutic efficacy of oral rehydration salts (ORS) by quantifying changes in heart rate during the head-up test (HUT) in children with postural tachycardia syndrome (POTS). " 06/01/2011 - "This study was designed to compare the short-term and long-term effects of oral rehydration salts, oral rehydration salts plus metoprolol or oral rehydration salts plus midodrine hydrochloride on the treatment of postural tachycardia syndrome (POTS) in children. "
8.	FludrocortisoneIBA 01/01/2009 - "The RGI group was younger, had a shorter duration of symptoms, more postural tachycardia syndrome (POTS) and benefited more from fludrocortisone (73% in RGI vs. 25% in NRGI). " 08/01/2001 - "Postural tachycardia syndrome in syringomyelia: response to fludrocortisone and beta-blockers." 01/01/2001 - "These also suggest that patients with the postural orthostatic tachycardia syndrome, and with the dysautonomic response, are better treated with fludrocortisone and midodrine." 12/01/2012 - "A literature search of PubMed for articles published from January 1, 1990, to June 15, 2012, was performed using the following terms (or combination of terms): POTS; postural tachycardia syndrome, orthostatic; orthostatic; syncope; sympathetic; baroreceptors; vestibulosympathetic; hypovolemia; visceral pain; chronic fatigue; deconditioning; headache; Chiari malformation; Ehlers-Danlos; emotion; amygdala; insula; anterior cingulate; periaqueductal gray; fludrocortisone; midodrine; propranolol; β-adrenergic; and pyridostigmine. "
9.	Biological Markers (Surrogate Marker)IBA 06/01/2015 - "[Diastolic and therapeutic value of biomarkers in children with postural tachycardia syndrome]." 10/01/2014 - "With the help of biomarkers, the therapeutic efficacy was greatly increased for children with postural tachycardia syndrome and vasovagal syncope." 10/01/2014 - "Assessment of therapeutic biomarkers in the treatment of children with postural tachycardia syndrome and vasovagal syncope."
10.	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 02/01/2012 - "To explore the predictive value of plasma hydrogen sulfide (H(2)S) in differentiating between vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children. " 02/01/2012 - "Plasma hydrogen sulfide in differential diagnosis between vasovagal syncope and postural orthostatic tachycardia syndrome in children." 10/01/2013 - "To evaluate the use of erythrocytic hydrogen sulfide (H2S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS). " 10/01/2013 - "Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride."

Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy) 01/01/2015 - "[Evaluation of the changes in heart rate during head-up test predicting the efficacy of oral rehydration salts on postural tachycardia syndrome in children]." 01/01/2015 - "To predict the therapeutic efficacy of oral rehydration salts (ORS) by quantifying changes in heart rate during the head-up test (HUT) in children with postural tachycardia syndrome (POTS). " 06/01/2011 - "This study was designed to compare the short-term and long-term effects of oral rehydration salts, oral rehydration salts plus metoprolol or oral rehydration salts plus midodrine hydrochloride on the treatment of postural tachycardia syndrome (POTS) in children. "
2.	Sympathectomy (Sympathectomies) 10/05/2000 - "The neuropathic postural tachycardia syndrome results from partial sympathetic denervation, especially in the legs." 08/01/2001 - "Partial sympathetic denervation of the legs in syringomyelia might explain the occasional occurrence of postural tachycardia syndrome. "
3.	Denervation 12/01/2014 - "Small-fiber neuropathy with cardiac denervation in postural tachycardia syndrome." 02/01/2008 - "Cardiac denervation in postural tachycardia syndrome."
4.	Examination Tables 03/01/2003 - "In contrast to other forms of orthostatic dysregulation - orthostatic hypotension (OH) and postural orthostatic tachycardia syndrome (POTS) - OI, hitherto, could be diagnosed only by a tilt table examination, with high expenditure. "
5.	Osteopathic Manipulation 11/01/2014 - "Osteopathic manipulative treatment for postural orthostatic tachycardia syndrome."