Type I Fatty Acid Synthase

Animal form of fatty acid synthase which is encoded by a single gene and consists of seven catalytic domains and is functional as a homodimer. It is overexpressed in some NEOPLASMS and is a target in humans of some ANTINEOPLASTIC AGENTS and some ANTI-OBESITY AGENTS.

Also Known As:

Fatty Acid Synthase, Type I; Fatty Acid Synthase, Animal Form; Fatty Acid Synthase, Mammalian

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586

Experts

1.	Ciccarelli, Luciano: 1 article (07/2013)
2.	Connell, Sean R: 1 article (07/2013)
3.	Enderle, Mathias: 1 article (07/2013)
4.	Grininger, Martin: 1 article (07/2013)
5.	Mills, Deryck J: 1 article (07/2013)
6.	Vonck, Janet: 1 article (07/2013)
7.	Anderson, Vernon E: 1 article (03/2002)
8.	Fillgrove, Kerry L: 1 article (03/2002)
9.	Liu, Binqiu: 1 article (03/2002)
10.	Wang, Yingqiang: 1 article (03/2002)

Related Diseases

1.	Tuberculosis (Tuberculoses) 07/02/2013 - "Antibiotic therapy in response to Mycobacterium tuberculosis infections targets de novo fatty acid biosynthesis, which is orchestrated by a 1.9 MDa type I fatty acid synthase (FAS). "
2.	Breast Neoplasms (Breast Cancer) 03/01/2002 - "Human type I fatty acid synthase has been proposed as a chemotherapeutic target for the treatment of breast cancer based on the inactivation of human beta-ketoacyl synthase activity by cerulenin. " 03/01/2002 - "Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells."

Related Drugs and Biologics

1.	Triclosan (pHisoHex)
2.	Oxidoreductases (Dehydrogenase)
3.	Fatty Acids (Saturated Fatty Acids)
4.	Cerulenin
5.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics