Oxylipins

Eighteen-carbon cyclopentyl polyunsaturated fatty acids derived from ALPHA-LINOLENIC ACID via an oxidative pathway analogous to the EICOSANOIDS in animals. Biosynthesis is inhibited by SALICYLATES. A key member, jasmonic acid of PLANTS, plays a similar role to ARACHIDONIC ACID in animals.

Also Known As:

Networked: 433 relevant articles (11 outcomes, 71 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Newman, John W: 23 articles (02/2022 - 12/2008)
2.	Hammock, Bruce D: 20 articles (05/2022 - 09/2006)
3.	Aukema, Harold M: 19 articles (01/2022 - 07/2014)
4.	Schebb, Nils Helge: 15 articles (10/2022 - 07/2013)
5.	Yang, Jun: 13 articles (05/2022 - 01/2012)
6.	Edin, Matthew L: 10 articles (11/2022 - 01/2016)
7.	Gouveia-Figueira, Sandra: 10 articles (01/2022 - 01/2015)
8.	Pedersen, Theresa L: 10 articles (01/2021 - 01/2012)
9.	Taha, Ameer Y: 9 articles (07/2022 - 01/2017)
10.	Chistyakov, Dmitry V: 9 articles (04/2022 - 08/2019)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2023 - "In the present study, we characterized the profile of the eCBome and related oxylipins in the small and large intestines of genetically obese (ob/ob) and diabetic (db/db) mice to decipher possible correlations between these mediators and intestinal inflammation and gut microbiota composition. " 12/01/2022 - "The aim of this study was to investigate if there are differences in symptom ratings and plasma concentrations of oxylipins as a measure of acute inflammation between individuals with building-related symptoms (BRS) and referents during exposure to rooms where people experienced BRS and rooms where they did not experience BRS. " 10/20/2022 - "Studies investigating oxylipin signaling have the potential to help explain mechanisms that mediate the impacts of inflammation on milk production. " 12/01/2020 - "The identified metabolite patterns suggest enzymatic mechanisms of oxylipin generation in AH and TF and might be used as a reference in ocular inflammation studies." 12/01/2020 - "This study aimed to establish the baseline patterns of PUFAs and oxylipins in AH and TF by their comprehensive lipidomic identification and profiling in humans in the absence of ocular inflammation and comparatively analyze these compounds in the eye liquids of rabbits, the species often employed in investigative ophthalmology. "
2.	Disease Progression 06/01/2019 - "COX2 inhibition ameliorates disease progression, improves renal function and improves the altered oxylipins in Pkd2 mice. " 01/01/2021 - "These distinct oxylipin networks could potentially elucidate pathways with clinical relevance for disease progression, clinical heterogeneity, and treatment response." 03/01/2015 - "Dietary flax oil may therefore reduce disease progression via mitigation of oxylipin abnormalities. " 09/01/2022 - "In vascular cognitive impairment (VCI), there is emerging evidence that oxylipins may have both protective and detrimental effects on brain structure, cognitive performance, and disease progression. " 03/01/2015 - "Since dietary flax oil ameliorates disease progression, its effect on renal fatty acids and oxylipins was examined. "
3.	Neoplasms (Cancer) 05/31/2022 - "These results demonstrate for the first time that high intake of ω-6 PUFAs in the diet enhances the malignancy of tumor cells by histological changes on tumor dedifferentiation and increases cell proliferation, angiogenesis, pro-inflammatory oxylipins and molecular aggressiveness targets such as NF-κB p65, YY1, COX-2 and TGF-β." 05/31/2020 - "These acetylenic oxylipins are widely distributed in plants belonging to the families Apiaceae, Araliaceae, and Asteraceae, and have shown to induce cell cycle arrest and/or apoptosis of cancer cells in vitro and to exert a chemopreventive effect on cancer development in vivo. " 01/01/2018 - "shiloi, and a high production of other oxylipins (cytotoxic compounds on their grazers and on cancer cell lines) for both diatoms, including some additional peaks not correlated to the canonic oxylipins commonly observed in planktonic diatoms. " 11/21/2022 - "Compared with the tumor-bearing animals, ten oxylipins were altered (three/ten n-6 oxylipins were elevated while seven/ten n-3 oxylipins were reduced) following chemotherapy. " 01/01/2016 - "Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics."
4.	Sepsis (Septicemia) 05/05/2023 - "Echocardiography, histopathology and oxylipin metabolomics were assessed at 16-20 h after inducing fatal sepsis. " 02/01/2016 - "Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis." 01/01/2022 - "These results support further investigation into the role of the P450 epoxygenase-derived oxylipins in sepsis and suggest that this pathway may offer a novel therapeutic strategy in septic shock." 02/01/2016 - "Both murine models of sepsis are characterized by changes of oxylipins formed in all branches of the arachidonic acid (AA) cascade. " 05/01/2016 - "This study provides new insights into the role of oxylipins in sepsis pathogenesis and highlights the potential of simvastatin and dLGG in sepsis therapy and prevention."
5.	Wounds and Injuries (Trauma) 06/01/2020 - "In this study, we assessed the relative contribution of JAs and GLVs to wound-induced systemic signaling and the associated regulation of oxylipins in local and systemic tissues of maize (Zea mays). " 01/30/2023 - "sativum, and their mixture at doses of 2000 and 5000 mg/kg. On the other side, moderate injuries were observed in animals treated with pure oxylipin and it was considered as toxic due to almost all the animals died. " 01/01/2022 - "A non-targeted metabolomics analysis identifies wound-induced oxylipins in Physcomitrium patens." 06/01/2020 - "This suggests that GLVs or other LOX10-derived products heavily contribute to overall basal and wound-induced oxylipin responses. " 06/01/2020 - "Our results show that GLV-deficiency and reduced JA in lox10 mutants had a greater impact on wound-induced local and systemic tissue oxylipin responses compared to the solely JA-deficient opr7opr8 double mutants. "

Related Drugs and Biologics

1.	Lipids
2.	Acids
3.	Hydroxyeicosatetraenoic Acids (HETE)
4.	Biomarkers (Surrogate Marker)
5.	Fatty Acids (Saturated Fatty Acids)
6.	Cytokines
7.	Endocannabinoids
8.	Lipopolysaccharides
9.	Sphingolipids
10.	Inflammation Mediators

Related Therapies and Procedures

1.	Therapeutics
2.	Punctures
3.	Bariatric Surgery
4.	Gastric Bypass (Roux-en-Y Gastric Bypass)
5.	Ligation