Small Molecule Libraries

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions. It includes virtual libraries.

Also Known As:

Networked: 105 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bohren, Kurt M: 2 articles (01/2021 - 01/2020)
2.	Faver, John C: 2 articles (01/2021 - 01/2020)
3.	Matzuk, Martin M: 2 articles (01/2021 - 01/2020)
4.	Nyshadham, Pranavanand: 2 articles (01/2021 - 01/2020)
5.	Ucisik, Melek Nihan: 2 articles (01/2021 - 01/2020)
6.	Yu, Zhifeng: 2 articles (01/2021 - 01/2020)
7.	Diamandis, Eleftherios P: 2 articles (10/2019 - 09/2008)
8.	Prassas, Ioannis: 2 articles (10/2019 - 09/2008)
9.	Hong, Andrew L: 2 articles (01/2019 - 09/2017)
10.	Hwang, Jong Yeon: 2 articles (11/2017 - 05/2016)

Related Diseases

1.	Inflammation (Inflammations) 05/01/2013 - "Furthermore, our study suggested that RAW cells maybe a simple and cost-effective model cell system to screen small molecule libraries to identify compounds that are effective in reducing RSV-induced inflammation." 01/01/2009 - "In addition, application of cell based assays simultaneously permits entry level evaluation of compound toxicity and endows with a powerful approach to perform high-throughput screenings of, e.g., small molecule libraries in a quest for novel compounds capable of influencing the inflammation process." 10/30/2009 - "The utility of these versatile assay components and their application for screening strategies was validated for all ten human Caspases, a family of intracellular proteases involved in cell death and inflammation, including implementation of assays for high throughput screening (HTS) of chemical libraries and functional screening of cDNA libraries. " 10/28/2013 - "We have explored the potential to complement NMR-based biophysical screening of chemical libraries with molecular docking in FBLD against the A(2A) adenosine receptor (A(2A)AR), a drug target for inflammation and Parkinson's disease. "
2.	Neoplasms (Cancer) 01/01/2019 - "In this study, we screened several MRT cell lines with large-scale RNAi, CRISPR-Cas9, and small-molecule libraries to identify potential drug targets specific for these cancers. " 01/01/2023 - "Therefore, there is an urgent need for new ex vivo, surrogate invasion assays that can faithfully recapitulate the cancer cell invasion process in vitro and are amenable to large-scale screening of small-molecule libraries in a high-throughput fashion. " 10/01/2021 - "Subsequently, large-scale screenings with RNAi, CRISPR/Cas9-sgRNAs, and chemical libraries have been applied to identify synthetic lethal partners of tumor suppressors. " 01/01/2021 - "Methods: To identify novel natural small molecular inhibitors of MTH1 to be used as cancer therapeutic agents, molecular screening for MTH1 active site binders was performed from natural small molecular libraries. " 01/01/2019 - "Long-term treatment and the challenge to monitor changes in tumor phenotype make testing of large chemical libraries in juvenile and adult animals cost prohibitive. "
3.	Malaria 07/09/2023 - "Prior studies showed that multiple compounds from the Medicines for Malaria Venture (MMV) chemical libraries were efficient PfATP4 inhibitors. " 10/01/2020 - "This study paves the way for building large chemical libraries to be investigated in the field of malaria." 11/21/2023 - "Efficacy data from diverse chemical libraries, screened against the various stages of the malaria parasite Plasmodium falciparum, including asexual blood stage (ABS) parasites and transmissible gametocytes, serve as a valuable reservoir of information on the chemical space of compounds that are either active (or not) against the parasite. " 02/01/2018 - "This paper describes an analysis of the diversity and chemical toxicity assessment of three chemical libraries of compounds from African flora (the p-ANAPL, AfroMalariaDb, and Afro-HIV), respectively containing compounds exhibiting activities against diverse diseases, malaria and HIV. " 01/01/2018 - "Phenotypic screening of chemical libraries against the malaria parasite is certainly a crucial step toward overcoming these crises. "
4.	Infections 12/01/2015 - "In this study, we performed a quantitative high throughput screening of the Molecular Libraries Small Molecule Repository (MLSMR) of ∼350,000 chemicals for novel HCV inhibitors using our previously developed cell-based HCV infection assay. " 03/01/2020 - "We present the current portfolio of next-generation anti-Wolbachia candidates discovered through phenotypic screening of chemical libraries and validated in a range of in vitro and in vivo filarial infection models. " 08/01/2014 - "To address this situation, we used high-throughput screening (HTS) of synthetic small molecule libraries to identify compounds that restrict Ad infection. " 05/01/2011 - "It is difficult to predict where the next generation of antimalarial drugs will come from; however, there are six major approaches: (i) re-optimizing the use of existing antimalarials by either replacement/rotation or combination approach; (ii) repurposing drugs that are currently used to treat other infections or diseases; (iii) chemically modifying existing antimalarial compounds; (iv) exploring natural sources; (v) large-scale screening of diverse chemical libraries; and (vi) through parasite genome-based ("targeted") discoveries. " 01/01/2017 - "In addition to measuring kinetic parameters of the debranching enzyme, these probes can be used for high throughput screening (HTS) of chemical libraries with the aim of identifying Dbr1 inhibitors, compounds that may be useful in treating neurodegenerative diseases and retroviral infections."
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2021 - "hiPSCs from individuals with neuropsychiatric or neurodegenerative diseases have facilitated biological and multi-omics studies as well as large-scale screening of chemical libraries. " 03/01/2019 - "castaneum is, therefore, a valuable model for the screening of neuroprotective substances in chemical libraries and plant extracts and could be developed as a model for the preclinical testing of therapeutic candidates for the treatment of neurodegenerative diseases, such as PD." 01/01/2017 - "In addition to measuring kinetic parameters of the debranching enzyme, these probes can be used for high throughput screening (HTS) of chemical libraries with the aim of identifying Dbr1 inhibitors, compounds that may be useful in treating neurodegenerative diseases and retroviral infections." 06/01/2012 - "Advances in the techniques used to monitor protein aggregation in vitro and in living cells have greatly facilitated the understanding of the molecular mechanism of amyloidogenic protein aggregation associated with neurodegenerative diseases, optimizing culture conditions to reduce aggregation of biopharmaceuticals expressed in living cells, and screening of small molecule libraries in the search for protein aggregation inhibitors."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Caspases
3.	Viral RNA
4.	Messenger RNA (mRNA)
5.	DNA-Directed RNA Polymerases (RNA Polymerase)
6.	DNA (Deoxyribonucleic Acid)
7.	Ligands
8.	Peptide Hydrolases (Proteases)
9.	Antiviral Agents (Antivirals)
10.	Inflammasomes

Related Therapies and Procedures

1.	Chemoprevention
2.	Therapeutics
3.	Precision Medicine
4.	Drug Therapy (Chemotherapy)
5.	Contraception (Birth Control)