Lipocalins

A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.

Also Known As:

Networked: 1176 relevant articles (19 outcomes, 153 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Devarajan, Prasad: 36 articles (01/2015 - 12/2004)
2.	Urade, Yoshihiro: 29 articles (09/2014 - 01/2002)
3.	Buemi, Michele: 18 articles (01/2015 - 01/2007)
4.	Barasch, Jonathan: 16 articles (02/2015 - 12/2004)
5.	Venge, Per: 14 articles (09/2015 - 01/2003)
6.	Ronco, Claudio: 14 articles (07/2015 - 01/2008)
7.	Ma, Qing: 14 articles (03/2015 - 12/2004)
8.	Bellomo, Rinaldo: 13 articles (12/2015 - 12/2007)
9.	Xu, Li-Yan: 13 articles (10/2015 - 02/2003)
10.	Li, En-Min: 13 articles (10/2015 - 02/2003)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 10/01/2015 - "Neutrophil gelatinase–associated lipocalin and contrast-induced acute kidney injury. " 01/01/2012 - "We sought to determine if an acute kidney injury biomarker, neutrophil gelatinaseassociated lipocalin (NGAL), would be up-regulated by high-intensity proteinuria-inducing exercise. " 01/01/2016 - "In our adjusted models, enrollment neutrophil gelatinase-associated lipocalin level was independently associated with survival even after controlling for the development of acute kidney injury, and its addition to clinical models improved overall predictive accuracy. " 09/01/2015 - "Neutrophil gelatinase associated lipocalin, also known as lipocalin-2, is a 25 kDa protein now considered the biochemical gold standard for the early diagnosis of acute kidney injury. " 02/01/2014 - "Acute kidney injury prediction improved when urine neutrophil gelatinase-associated lipocalin was added to a clinical model (area under the curve increased at 1 hr from 0.85 to 0.91 and at 3 hr to 0.92). "
2.	Neoplasms (Cancer) 06/20/2015 - "Lipocalin 2 (LCN2), a tumor-associated protein, is overexpressed in a variety of cancer types. " 06/15/2015 - "Lipocalin 2 (LCN2), a member of the lipocalin family, is aberrantly expressed in some human cancers and has been implicated in the progression of some tumors. " 03/01/2014 - "Many lipocalins play crucial roles in the generation of epithelial cancer, influencing pathways which regulate cell motility, cell differentiation and neovascularisation. " 08/01/2013 - "Lipocalin 2 (LCN2) is related to cancer development and is believed to be associated with the outcome of cytogenetically normal (CN)-AML. " 04/01/2013 - "CCL2 secondarily induces Lipocalin 2 (LCN2) in the Snail(+) tumor cells in an autocrine manner. "
3.	Sepsis (Septicemia) 06/01/2010 - "This study aims to determine whether urinary neutrophil gelatinase-associated lipocalin (uNGAL) rises in culture-positive sepsis and, if so, is elevated at the time sepsis is suspected. " 01/15/2016 - "Value of plasma neutrophil gelatinase-associated lipocalin in predicting the mortality of patients with sepsis at the emergency department." 07/01/2015 - "To assess the ability of urinary neutrophil gelatinase-associated lipocalin (UNGAL) to discriminate between culture-positive vs. culture-negative late-onset sepsis evaluations. " 07/01/2015 - "Urinary neutrophil gelatinase-associated lipocalin: potential biomarker for late-onset sepsis." 01/01/2015 - "Neutrophil gelatinase-associated lipocalin (NGAL), which is an important prognostic marker for sepsis and inflammatory diseases, is mostly released from neutrophils. "
4.	Inflammation 10/01/2014 - "Lipocalin-2 (LCN2) belongs to the superfamily of lipocalins and plays critical roles in the control of cellular homeostasis during inflammation and in responses to cellular stress or injury. " 05/01/2013 - "One of the more recently discovered mediators in the context of airway inflammation are the lipocalins (Lcns). " 01/01/2012 - "Herein, we report that, for assessment of intestinal inflammation, fecal lipocalin 2 (Lcn-2), measured by ELISA, serves this purpose. " 01/01/2012 - "Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation." 01/01/2011 - "Lipocalin 2 (Lcn2) is a bacteriostatic factor that may also modulate cellular function, however, little is known concerning the expression or role of Lcn2 in CNS inflammation. "
5.	Urinary Tract Infections (Urinary Tract Infection) 12/15/2014 - "Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection." 06/26/2015 - "During Escherichia coli urinary tract infections, cells in the human urinary tract release the antimicrobial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-associated lipocalin/NGAL, or 24p3). " 09/01/2014 - "Evaluation of the optimal neutrophil gelatinase-associated lipocalin value as a screening biomarker for urinary tract infections in children." 12/01/2013 - "Elevation of neutrophil gelatinase-associated lipocalin (NGAL) in non-azotemic dogs with urinary tract infection." 06/01/2011 - "Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia."

Related Drugs and Biologics

1.	Gelatinases
2.	Creatinine
3.	Biological Markers (Surrogate Marker)
4.	Cystatin C
5.	Interleukin-18 (Interleukin 18)
6.	Carrier Proteins (Binding Protein)
7.	Proteins (Proteins, Gene)
8.	Messenger RNA (mRNA)
9.	Transforming Growth Factors (Transforming Growth Factor)
10.	Urea (Carbamide)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Drug Therapy (Chemotherapy)
3.	Nephrectomy
4.	Cardiopulmonary Bypass (Heart-Lung Bypass)
5.	Liver Transplantation