Acridones

Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.

Networked: 26 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mayur, Y C: 6 articles (10/2017 - 01/2006)
2.	Peters, G J: 4 articles (09/2022 - 05/2009)
3.	Dodean, Rozalia A: 3 articles (01/2021 - 11/2007)
4.	Kelly, Jane X: 3 articles (01/2021 - 11/2007)
5.	Peters, Godefridus J: 3 articles (06/2018 - 11/2009)
6.	Rajendra Prasad, V V S: 3 articles (06/2018 - 07/2011)
7.	Murahari, Manikanta: 2 articles (09/2022 - 10/2017)
8.	Kancharla, Papireddy: 2 articles (01/2021 - 11/2019)
9.	Cooper, Roland A: 2 articles (11/2019 - 11/2007)
10.	Smilkstein, Martin J: 2 articles (11/2019 - 11/2007)

Related Diseases

1.	Neoplasms (Cancer) 09/05/2022 - "This review also provides some important insights on the design, receptor targeting and future directions for the development of acridones as possible clinically effective anti-cancer agents." 06/01/2018 - "Elucidation of chemosensitization effect of acridones in cancer cell lines: Combined pharmacophore modeling, 3D QSAR, and molecular dynamics studies." 12/01/2009 - "A total of seven new oxyranylmethyloxy or thiiranylmethyloxy group substituted 5-azaxanthones and -acridones analogues were synthesized and tested for their biological activities for cancer cell lines and topoisomerases. " 03/01/2013 - "In addition an efficient pharmacophore model was developed from a set of 38 chemosensitizing acridones effective against doxorubicin resistant (HL-60/DX) cancer cell lines. " 09/15/2015 - "In the present study, we investigated the cytotoxicity of five alkaloids including a furoquinoline montrofoline (1) and four acridones namely 1-hydroxy-4-methoxy-10-methylacridone (2), norevoxanthine (3), evoxanthine (4), 1,3-dimethoxy-10-methylacridone (5) against 9 drug-sensitive and multidrug-resistant (MDR) cancer cell lines. "
2.	Breast Neoplasms (Breast Cancer) 06/01/2018 - "Pharmacophore modeling was performed for the dataset of chemosensitizing acridones earlier proved for cytotoxic activity against MCF7 breast cancer cell line. " 01/01/2019 - "Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N'-dialkyl-9,9'-biacridylidenes."
3.	Falciparum Malaria (Plasmodium falciparum Malaria) 11/01/2007 - "A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. "
4.	Virus Diseases (Viral Diseases) 12/01/2004 - "The purpose of this mini-review is to highlight the renewed interest in acridones for antiviral drug research, with the emphasis placed on several derivatives in early stage development for treating herpes virus infection. "
5.	Toxoplasmosis 01/01/2021 - "We identify acridones that have efficacy in a murine model of systemic toxoplasmosis. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	DNA (Deoxyribonucleic Acid)
3.	Alkaloids
4.	Calmodulin (Calcium-Dependent Activator Protein)
5.	acridone
6.	Member 1 Subfamily B ATP Binding Cassette Transporter
7.	Vinblastine (Vinblastine Sulfate)
8.	Proteins (Proteins, Gene)
9.	Antiviral Agents (Antivirals)
10.	Amines

Related Therapies and Procedures

1.	Oral Administration