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Cyclic Nucleotide-Gated Cation Channels

A subgroup of cyclic nucleotide-regulated ION CHANNELS within the superfamily of pore-loop cation channels. They are expressed in OLFACTORY NERVE cilia and in PHOTORECEPTOR CELLS and some PLANTS.
Also Known As:
CNG Channel (Rod); Cationic Channel Protein (Rod); Cng Cation Channel; Cyclic Nucleotide-Gated Cation Channel; Cyclic-Nucleotide Gated Channel; Cation Channel, Cng; Channel, Cng Cation; Channel, Cyclic-Nucleotide Gated; Cyclic Nucleotide Gated Cation Channel; Cyclic Nucleotide Gated Cation Channels; Cyclic Nucleotide Gated Channel; Cyclic Nucleotide Gated Ion Channels; Gated Channel, Cyclic-Nucleotide; Cyclic-Nucleotide Gated Ion Channels
Networked: 95 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Onat, Filiz: 2 articles (01/2022 - 01/2018)
2. Çarçak, Nihan: 2 articles (01/2022 - 01/2018)
3. Lee, Michael C: 2 articles (11/2021 - 11/2019)
4. McNaughton, Peter A: 2 articles (11/2021 - 09/2014)
5. Scholtes, Ingrid: 2 articles (11/2021 - 11/2019)
6. Biel, Martin: 2 articles (10/2021 - 01/2005)
7. Michalakis, Stylianos: 2 articles (10/2021 - 01/2005)
8. Crunelli, Vincenzo: 2 articles (01/2021 - 01/2018)
9. David, François: 2 articles (01/2021 - 01/2018)
10. Lőrincz, Magor L: 2 articles (01/2021 - 01/2018)

Related Diseases

1. Cognitive Dysfunction
2. Hyperglycemia
3. Fibrosis (Cirrhosis)
4. Color Vision Defects (Color Blindness)
5. Retinitis Pigmentosa (Pigmentary Retinopathy)
10/01/2021 - "Retinitis pigmentosa type 45 (RP45) is an autosomal-recessively inherited blinding disease caused by mutations in the cyclic nucleotide-gated channel subunit beta 1 (CNGB1) gene. "
01/01/2023 - "In this study, we investigate a gene augmentation therapy candidate for the treatment of retinitis pigmentosa (RP) due to cyclic nucleotide-gated channel beta 1 (CNGB1) mutations. "
04/11/2002 - "A mutation in a cyclic nucleotide-gated channel (CNGA1) is associated with retinitis pigmentosa (RP), a common, inherited eye disease. "
08/01/2011 - "shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa."
01/01/2017 - "These studies provided the essential proof-of-concept needed to advance monogenic gene therapies into clinic development; these therapies include treatments for: Leber's congenital amaurosis type 2, caused by mutations to RPE65, retinoid isomerohydrolase; choroideremia, caused by mutations to REP1, Rab escort protein 1; autosomal recessive Stargardt disease, caused by mutations to ABCA4, the photoreceptor-specific ATP-binding transporter; Usher 1B disease caused by mutations to MYO7A, myosin heavy chain 7; X-linked juvenile retinoschisis caused by mutations to RS1, retinoschisin; autosomal recessive retinitis pigmentosa caused by mutations to MERTK, the proto-oncogene tyrosine-protein kinase MER; Leber's hereditary optic neuropathy caused by mutations to ND4, mitochondrial nicotinamide adenine dinucleotide ubiquinone oxidoreductase (complex I) subunit 4 and achromatopsia, caused by mutations to CNGA3, cyclic nucleotide-gated channel alpha 3 and CNGB3, cyclic nucleotide-gated channel beta 3. This review includes a tabulated summary of treatments for these monogenic retinal dystrophies that have entered into clinical development, as well as a brief summary of the preclinical data that supported their advancement into clinical development."

Related Drugs and Biologics

1. Ivabradine
2. Streptozocin (Streptozotocin)
3. Fluoxetine (Prozac)
4. Proteins (Proteins, Gene)
5. Protein Isoforms (Isoforms)
6. Ion Channels (Ion Channel)
7. Type 2 Cyclic Nucleotide Phosphodiesterases
8. Apoptosis Inducing Factor
9. GTP-Binding Proteins (G-Protein)
10. Myosin Heavy Chains (Myosin Heavy Chain)

Related Therapies and Procedures

1. Therapeutics
2. Electroacupuncture