Polyhydroxyalkanoates

Biodegradable microbial polyesters which contain hydroxyacyl monomers. Polyhydroxyalkanoates are carbon and energy reserve materials produced and sequestered in cytoplasmic granules called polyhydroxyalkanoate or PHA granules by various archaea and bacteria and may additionally provide protective mechanism to the microbes. They are biosynthesized by microbial polyhydroxyalkanoate synthase enzymes using fatty acids or citramalate synthase enzymes using glucose.

Also Known As:

Networked: 56 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roy, Ipsita: 4 articles (08/2021 - 08/2006)
2.	Nikodinovic-Runic, Jasmina: 3 articles (03/2022 - 04/2013)
3.	Basnett, Pooja: 3 articles (08/2021 - 08/2019)
4.	Masood, Farha: 3 articles (03/2016 - 04/2013)
5.	O'Connor, Kevin E: 3 articles (06/2015 - 02/2007)
6.	Chen, Guo-Qiang: 3 articles (09/2014 - 03/2011)
7.	Higuchi-Takeuchi, Mieko: 2 articles (01/2019 - 01/2016)
8.	Huang, Yue: 2 articles (01/2019 - 01/2019)
9.	Jendrossek, Dieter: 2 articles (01/2019 - 01/2017)
10.	Liu, Qinghua: 2 articles (01/2019 - 01/2019)

Related Diseases

1.	Infections 01/01/2014 - "These findings support a contact active surface mode of antibacterial action for PHACOS and establish this functionalized polyhydroxyalkanoate as an infection-resistant biomaterial." 12/01/2004 - "There is a need for improved antibiotic delivery systems in the treatment of orthopaedic infections and here we have evaluated polyhydroxyalkanoate formulations for their suitability as a constant delivery system for gentamicin. "
2.	Candidiasis (Moniliasis) 03/24/2022 - "Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model."
3.	Polyps 03/01/2000 - "This organism accumulates polyhydroxyalkanoates anaerobically and polyP under aerobic conditions. " 10/01/2012 - "Under aerobic conditions, they accumulate intracellular polyphosphate (polyP), while they typically synthesize polyhydroxyalkanoates (PHAs) under anaerobic conditions. " 03/01/2006 - "Polyhydroxyalkanoates (PHA) but not polyphosphate (polyP) granules were detected in all GB bacterial cells. " 01/01/2013 - "The seven analyzed models are: (1) ASM1; (2) ASM2d; (3) ASM3; (4) ASM3 + BioP; (5) ASM2d + TUD; (6) Barker & Dold model; and (7) UCTPHO+. Nine standard processes are distinguished and discussed in the present work: hydrolysis; fermentation; ordinary heterotrophic organisms (OHO) growth; autotrophic nitrifying organisms (ANO) growth; OHO & ANO decay; poly-hydroxyalkanoates (PHA) storage; polyphosphate (polyP) storage; phosphorus accumulating organisms PAO) growth; and PAO decay. " 02/01/2007 - "Pseudomonas putida CA-3 accumulates polyphosphate (polyP) and medium-chain-length polyhydroxyalkanoate (mclPHA) concurrently under nitrogen limitation. "
4.	Neoplasms (Cancer) 03/01/2011 - "In this study, we developed a sustained release system of PI3K inhibitor (TGX221) based on polyhydroxyalkanoate nanoparticles (NP) and used it to block proliferation of cancer cell lines. " 04/01/2015 - "Role of polyhydroxyalkanoates in cancer and other drug delivery systems." 01/01/2010 - "Polyhydroxyalkanoates: important in cancer and other drug discovery systems." 06/01/2020 - "Microbiologically extracted poly(hydroxyalkanoates) and its amalgams as therapeutic nano-carriers in anti-tumor therapies." 04/01/2013 - "The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate."
5.	Wounds and Injuries (Trauma) 08/01/2006 - "Over the years, efforts have been made to extend the group of polyhydroxyalkanoates and to investigate their use in numerous biomedical applications, such as sutures, cardiovascular patches, wound dressings, guided tissue repair/regeneration devices, and tissue engineering scaffolds. " 01/01/2020 - "In this study, we demonstrate a novel, biocompatible wound dressing material, based on Polyhydroxyalkanoates, doped with graphene platelets, which can be used as an electrochemical sensing substrate for the detection of a common wound pathogen, Pseudomonas aeruginosa. " 08/28/2021 - "Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications." 01/01/2020 - "Bacteria-triggered release of a potent biocide from core-shell polyhydroxyalkanoate (PHA)-based nanofibers for wound dressing applications." 09/01/2014 - "We studied the effects of anti-inflammatory substances incorporated in polymeric microparticles made of degradable natural polyhydroxyalkanoate polyesters on experimental skin wounds caused by chemical burns in laboratory animals. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Biopolymers (Biopolymer)
3.	Therapeutic Uses
4.	Polyenes
5.	Gentamicins (Gentamicin)
6.	Polyphosphates
7.	Glycogen
8.	Acids
9.	Triglycerides (Triacylglycerol)
10.	Esters

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Therapeutics
3.	Sutures (Suture)
4.	Photobioreactors