HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Phospholipase C beta

Subscribe to New Research on Phospholipase C beta

A phosphoinositide phospholipase C subtype that is primarily regulated by its association with HETEROTRIMERIC G-PROTEINS. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues.

Also Known As:

PLC beta; PLC beta1; PLC beta2; PLC beta3; PLC beta4; Phospholipase C beta1; Phospholipase C beta2; Phospholipase C beta3; Phospholipase C beta4; Phospholipase C-beta; Phospholipase C-beta1; Phospholipase C-beta2; Phospholipase C-beta3; Phospholipase C-beta4

Networked: 86 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cocco, Lucio: 5 articles (01/2007 - 05/2002)
2.	Martelli, Alberto M: 4 articles (01/2007 - 05/2002)
3.	Wu, Dianqing: 3 articles (08/2009 - 09/2003)
4.	Faenza, Irene: 3 articles (01/2007 - 05/2002)
5.	Manzoli, Lucia: 3 articles (01/2007 - 05/2002)
6.	Cocco, L: 2 articles (05/2012 - 06/2004)
7.	Manzoli, L: 2 articles (05/2012 - 06/2004)
8.	Benati, Donatella: 2 articles (06/2009 - 03/2008)
9.	Merigo, Flavia: 2 articles (06/2009 - 03/2008)
10.	Osculati, Francesco: 2 articles (06/2009 - 03/2008)

Related Diseases

1.	Heart Failure 03/01/2000 - "We conclude that altered protein expression and stoichiometry of the major cardiomyocyte Ca2+ cycling proteins rather than reduced phospholipase C beta 1 activation may contribute to improved mechanical function produced by left ventricular assist device support in human heart failure." 03/10/1998 - "Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction."
2.	Multiple Endocrine Neoplasia Type 1 (MEN I) 01/01/1997 - "In this study, the structure and expression of the PLC beta 3 gene in MEN 1 patients were investigated in more detail, to determine its potential role in MEN 1 tumorigenesis. " 12/01/1995 - "For clarification of the role of PLC beta 3 in MEN 1 parathyroid tumorigenesis further study of this protein is required." 01/01/1997 - "In conclusion, these results exclude the PLC beta 3 gene as a candidate gene for MEN 1." 01/01/1997 - "To detect possible point mutations, or other small structural aberrations, direct sequencing of PLC beta 3 cDNAs from two affected persons from two different MEN 1 families was performed, but no MEN 1-specific abnormalities were revealed. " 01/01/1997 - "Our previous attempts to identify the MEN1 gene have resulted in the isolation of the phospholipase C beta 3 gene from the actual region. "
3.	Neoplasms (Cancer) 01/01/1996 - "Finally, the assignment of the PLC beta 1 gene to the band q35-36 of rat chromosome 3 paves the way for further genetic studies given the fact that the region where PLC beta 1 gene maps is a hot spot for genetic alterations in a number of experimentally induced rat tumors. " 08/04/2009 - "Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5." 12/01/1995 - "Parathyroid PLC beta 3 invariably was homogeneously expressed, and this included even MEN 1 patients with reduced PLC beta 3 expression in endocrine pancreatic tumors. " 12/01/1998 - "These results provide the first evidence that elevated levels of endogenous PI-PLC beta 1 suppress tumor cell growth, but enhance the ability to form cell aggregates and to release carcinoembryonic antigen, an intercellular adhesion molecule." 11/01/1996 - "These findings have prompted us to better characterise the nuclear PLC beta 1. The isoform beta 1 has been studied as a possible target for anti-cancer drugs and as an inducer, via diacylglycerol generation, of the translocation of specific protein kinase C (PKC) isozyme to the nucleus. "
4.	Schizophrenia (Dementia Praecox) 02/01/2011 - "Our data confirm that phospholipase C beta 1 transcript levels are decreased in the dorsolateral prefrontal cortex from subjects with schizophrenia. " 02/01/2011 - "There was no significant difference in the protein levels of either phospholipase C beta 1 variant in schizophrenia, irrespective of duration of illness (variant a; P = 0.84, variant b; P = 0.73). " 02/01/2011 - "Compared to age/sex matched controls, levels of phospholipase C beta 1 variant a and b mRNAs were decreased (-33% and -50%, respectively) in short duration schizophrenia. " 02/01/2011 - "Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness." 12/15/1999 - "Changes in PLC beta 1 immunoreactivities in the prefrontal and superior temporal cortex of patients with schizophrenia may reflect abnormalities in neurotransmissions via receptors that are coupled with the Gq alpha-PLC beta 1 cascade."
5.	Pain (Aches) 11/01/2007 - "These studies support the suggestion that PLC-beta 3 is an important upstream signaling molecule for PKC epsilon-mediated acute and chronic inflammatory pain." 09/03/2003 - "Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain." 09/03/2003 - "Phospholipase C (PLC) beta4, one of the four isoforms of PLCbetas, is the sole isoform expressed in the mouse ventral posterolateral thalamic nucleus (VPL), a key station in pain processing. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phospholipase C beta
3.	Messenger RNA (mRNA)
4.	Phosphatidylinositols (Phosphatidylinositol)
5.	Protein Kinase C-epsilon
6.	Glucose (Dextrose)
7.	Calcium
8.	antineoplaston A10 (A 10)
9.	Type C Phospholipases
10.	Phospholipase C gamma

Related Therapies and Procedures

1.	Heart Transplantation (Grafting, Heart)
2.	Lasers (Laser)
3.	Aftercare (After-Treatment)