G-Protein-Coupled Receptor Kinase 2

A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS. It may play an essential role in regulating myocardial contractile response.

Also Known As:

Networked: 151 relevant articles (5 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Koch, Walter J: 18 articles (01/2017 - 09/2003)
2.	Mayor, Federico: 13 articles (08/2020 - 07/2008)
3.	Wei, Wei: 8 articles (12/2021 - 05/2016)
4.	Iaccarino, Guido: 8 articles (11/2020 - 10/2009)
5.	Kavelaars, Annemieke: 8 articles (01/2018 - 04/2004)
6.	Gao, Erhe: 8 articles (01/2017 - 08/2008)
7.	Trimarco, Bruno: 7 articles (11/2020 - 12/2009)
8.	Murga, Cristina: 7 articles (01/2019 - 07/2008)
9.	Heijnen, Cobi J: 7 articles (01/2018 - 04/2004)
10.	Penela, Petronila: 6 articles (08/2020 - 07/2008)

Related Diseases

1.	Heart Failure 05/01/2012 - "G-protein-coupled receptor kinase 2 ablation impedes heart failure development, but elucidation of the cellular mechanisms has not been achieved, and such elucidation is the aim of this study. " 10/01/2019 - "The expression of G protein-coupled receptor kinase 2 (GRK2), a key signaling hub, is up-regulated in the long-term in patients and in experimental models of heart failure. " 01/01/2018 - "Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. " 01/01/2017 - "Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure." 10/28/2016 - "G protein-coupled receptor kinase 2 (GRK2) is an important molecule upregulated after myocardial injury and during heart failure. "
2.	Myocardial Infarction 09/01/2013 - "To investigate the G protein-coupled receptor kinase 2 (GRK 2) level in peripheral blood lymphocytes with cardiac function in elderly patients with acute myocardial infarction. " 05/01/2012 - "Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction." 04/15/2011 - "G protein-coupled receptor kinase 2 in patients with acute myocardial infarction." 01/01/2013 - "Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction. " 08/15/2008 - "G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure."
3.	Inflammation (Inflammations) 06/01/2023 - "The CXCL9, 10, 11/CXCR3 axis and G protein-coupled receptor kinase 2 (GRK2) involved in many inflammation and immunity processes. " 07/19/2022 - "The G-protein-coupled receptor kinase 2 (GRK2) is an important regulator of inflammation and pathological macrophage phenotype in a variety of diseases. " 02/01/2021 - "G-protein-coupled receptor kinase 2 (GRK2) contributes to the modulation of basic cellular functions-such as cell proliferation, survival or motility-and is involved in metabolic homeostasis, inflammation or angiogenic processes. " 11/01/2013 - "G-protein-coupled receptor kinase 2 (GRK2) levels are elevated in inflammation but its role is not clear yet. " 05/01/2013 - "Inflammation-induced G protein-coupled receptor kinase 2 (GRK2) downregulation and genetic deletion of GRK2 mimicked the sensitizing effect of inflammation on excitotoxic neurodegeneration. "
4.	Hypoxia (Hypoxemia) 01/01/2006 - "Over-expression of a catalytically inactive G protein-coupled receptor kinase 2 (GRK2 K220R) blocked the increased phosphorylation and sequestration of the M2, but not M1, mAChRs following transient hypoxia. " 03/26/2008 - "Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage." 04/01/2004 - "Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain." 09/13/2011 - "Hypoxia resulted in overactivation of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activation of downstream pathways including G(αi) and Ras-related C3 botulinum toxin substrate 1. These data identify stereotyped and selective hypoxia-induced cerebral cortical disruption requiring LPA(1) signaling, inhibition of which can reduce or prevent disease-associated sequelae, and may take us closer to therapeutic treatment of fetal hypoxia-induced CNS disorders and possibly other forms of hypoxic injury."
5.	Ventricular Remodeling 10/01/2021 - "To investigate the efficacy of paroxetine-mediated G-protein-coupled receptor kinase 2 inhibition to mitigate adverse left ventricular remodeling in patients presenting with acute myocardial infarction. "

Related Drugs and Biologics

1.	Paroxetine (Paxil)
2.	beta Adrenergic Receptors
3.	Protein Kinases (Protein Kinase)
4.	Mitogen-Activated Protein Kinase 3
5.	rac1 GTP-Binding Protein
6.	Protein Isoforms (Isoforms)
7.	Calcium-Calmodulin-Dependent Protein Kinases
8.	Protein Kinase C
9.	protein kinase D
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Ligation
2.	Therapeutics
3.	Punctures