Imidazoline Receptors

Receptors of CLONIDINE and other IMIDAZOLINES. Activity of the ligands was earlier attributed to ADRENERGIC ALPHA-2 RECEPTORS. Endogenous ligands include AGMATINE, imidazoleacetic acid ribotide, and harman.

Also Known As:

Networked: 55 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zheng, Rong-Yuan: 3 articles (11/2012 - 05/2006)
2.	Tripathi, Sunil J: 2 articles (06/2013 - 09/2009)
3.	Chopde, Chandrabhan T: 2 articles (06/2013 - 09/2009)
4.	Kotagale, Nandkishor R: 2 articles (06/2013 - 09/2009)
5.	Taksande, Brijesh G: 2 articles (06/2013 - 09/2009)
6.	Hou, Sheng-Tao: 2 articles (11/2012 - 03/2011)
7.	Mukaddam-Daher, Suhayla: 2 articles (09/2012 - 03/2011)
8.	Head, G A: 2 articles (09/2000 - 06/2000)
9.	Burke, S L: 2 articles (09/2000 - 06/2000)
10.	Nemutlu, Dilara: 1 article (09/2015)

Related Diseases

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 03/04/2011 - "Our previous studies showed that ligands to type 2 imidazoline receptors (I(2)R) were effective in protecting spinal cord injury caused by experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. In this study, we further examined the protective property of a very selective ligand of I(2)R, 2-(2-benzofuranyl) 2-imidazoline (2-BFI) against EAE. " 11/05/2012 - "Our previous studies showed that ligands to type 2 imidazoline receptors (I₂R), including 2-(2-Benzofuranyl)-2-imidazoline (2-BFI) and Idazoxan, were effective in reducing spinal cord inflammation caused by experimental autoimmune encephalomyelitis (EAE). "
2.	Hypertension (High Blood Pressure) 04/01/2000 - "Potential benefits of imidazoline receptors agonist drugs in treatment of systemic hypertension." 12/01/1997 - "An upregulation of imidazoline receptors in hypertension may contribute to the effects observed." 01/01/1995 - "Imidazoline Receptors in a Comprehensive Approach to Hypertension. " 05/01/1994 - "Whether this decrease in activity of the natriuretic non-adrenoceptor, imidazoline receptors contributes to the increase in blood pressure in the 1K-1C acquired model of hypertension remains to be determined." 03/01/1992 - "In SHR rats, the density of imidazoline receptors (hypothalamus greater than medulla oblongata greater than cerebral cortex) and proportion of high- and low-affinity sites for the receptor were not different from those in WKY and SD rats, suggesting that the receptor itself is not altered in hypertension. "
3.	Pain (Aches) 09/01/2015 - "In this respect, the involvement of the imidazoline receptors in pain modulation has drawn attention in recent years. " 09/01/2015 - "This educational forum exhibits the role of imidazoline receptors and ligands in pain process by utilizing experimental studies. " 09/01/2015 - "Thus, the use of the ligands which bind to the imidazoline receptors is an effective strategy for relieving pain. " 09/01/2015 - "In this review, it is aimed to focus on the imidazoline receptors and their ligands which contribute to the pain modulation. " 09/01/2015 - "The imidazoline receptors and ligands in pain modulation."
4.	Spinal Cord Injuries (Spinal Cord Injury) 03/04/2011 - "Our previous studies showed that ligands to type 2 imidazoline receptors (I(2)R) were effective in protecting spinal cord injury caused by experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. In this study, we further examined the protective property of a very selective ligand of I(2)R, 2-(2-benzofuranyl) 2-imidazoline (2-BFI) against EAE. "
5.	Myelitis 11/05/2012 - "Our previous studies showed that ligands to type 2 imidazoline receptors (I₂R), including 2-(2-Benzofuranyl)-2-imidazoline (2-BFI) and Idazoxan, were effective in reducing spinal cord inflammation caused by experimental autoimmune encephalomyelitis (EAE). "

Related Drugs and Biologics

1.	Ligands
2.	Idazoxan
3.	2-(2-benzofuranyl)-2-imidazoline
4.	2-imidazoline
5.	moxonidine (Moxon)
6.	rilmenidine (Hyperium)
7.	Clonidine (ST 155)
8.	Adrenergic Receptors (Adrenergic Receptor)
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Agmatine