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Follicular Dendritic Cell Sarcoma

Subscribe to New Research on Follicular Dendritic Cell Sarcoma

Sarcoma of FOLLICULAR DENDRITIC CELLS most often found in the lymph nodes. This rare neoplasm occurs predominately in adults.

Also Known As:

Dendritic Cell Sarcoma, Follicular

Networked: 29 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Malignant Histiocytic Disorders
    - Follicular Dendritic Cell Sarcoma: 29
Hemic and Lymphatic Diseases
- Lymphatic Diseases: 2658
  - Histiocytosis: 321
    - Malignant Histiocytic Disorders
      - Follicular Dendritic Cell Sarcoma: 29

Related Diseases

1.	Neoplasms (Cancer)
2.	Giant Lymph Node Hyperplasia (Castleman's Disease)
3.	Pemphigus (Pemphigus Vulgaris)
4.	Solitary Fibrous Tumors
5.	Sinus Histiocytosis (Rosai-Dorfman Disease)

Experts

1.	Hornick, Jason L: 3 articles (01/2016 - 02/2002)
2.	Fletcher, Christopher D M: 2 articles (01/2016 - 02/2002)
3.	Hashimoto, Takashi: 2 articles (01/2013 - 12/2004)
4.	Sholl, Lynette M: 1 article (01/2016)
5.	Lindeman, Neal I: 1 article (01/2016)
6.	Griffin, Gabriel K: 1 article (01/2016)
7.	Tocco, Alessandra: 1 article (11/2015)
8.	Spatola, Corrado: 1 article (11/2015)
9.	Militello, Carmelo: 1 article (11/2015)
10.	Bevilacqua, Roberta: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Follicular Dendritic Cell Sarcoma:

1.	Epidermal Growth Factor Receptor (EGF Receptor)IBA 09/15/2013 - "The aim of this study was to investigate the biological and clinical significance of epidermal growth factor receptor (EGFR) signaling pathway in follicular dendritic cell sarcoma (FDC-S). " 09/01/2003 - "Epidermal growth factor receptor expression in follicular dendritic cells: a shared feature of follicular dendritic cell sarcoma and Castleman's disease."
2.	Immunoglobulin G (IgG)IBA 12/01/2004 - "A direct immunofluorescence study of autopsy samples showed IgG deposition in the epidermis of the skin and oral mucosal membrane, but not in the lungs and kidneys and follicular dendritic cell sarcoma of the para-aortic area. "
3.	AntigensIBA 10/01/2013 - "We describe a patient with PNP associated with follicular dendritic cell sarcoma (FDCS), a rare neoplasm originating from follicular dendritic cells, which are non-lymphoid, non-phagocytic accessory cells of the lymphoid system and play an integral role in regulation of the germinal center reaction and present antigens to B-cells. " 09/01/2005 - "Western blot showed that the medium from both the thymoma and the follicular dendritic cell sarcoma cells recognized 190-kDa periplakin and 210-kDa envoplakin bands of human epithelial proteins as well as recombinant linker regions of periplakin, envoplakin, desmoplakin and bullous pemphigoid antigen 1. ELISA was positive for antidesmoglein 3 antibody. " 08/01/2007 - "PNP patient sera recognize multiple antigens, which have been identified as the plakin protein family that includes desmoplakin, bullous pemphigoid antigen I (BPAG1), envoplakin and periplakin, and desmogleins 1 and 3. Castleman's tumor, non-Hodgkin's lymphoma, thymoma, follicular dendritic cell sarcoma and chronic lymphocytic leukemia are the commonly associated neoplasmas in PNP. "
4.	DesmogleinsIBA 12/01/2004 - "Antibody titers to desmogleins 1 and 3 in a patient with paraneoplastic pemphigus associated with follicular dendritic cell sarcoma." 08/01/2007 - "PNP patient sera recognize multiple antigens, which have been identified as the plakin protein family that includes desmoplakin, bullous pemphigoid antigen I (BPAG1), envoplakin and periplakin, and desmogleins 1 and 3. Castleman's tumor, non-Hodgkin's lymphoma, thymoma, follicular dendritic cell sarcoma and chronic lymphocytic leukemia are the commonly associated neoplasmas in PNP. "
5.	Desmoplakins (Desmoplakin)IBA 09/01/2005 - "Western blot showed that the medium from both the thymoma and the follicular dendritic cell sarcoma cells recognized 190-kDa periplakin and 210-kDa envoplakin bands of human epithelial proteins as well as recombinant linker regions of periplakin, envoplakin, desmoplakin and bullous pemphigoid antigen 1. ELISA was positive for antidesmoglein 3 antibody. " 08/01/2007 - "PNP patient sera recognize multiple antigens, which have been identified as the plakin protein family that includes desmoplakin, bullous pemphigoid antigen I (BPAG1), envoplakin and periplakin, and desmogleins 1 and 3. Castleman's tumor, non-Hodgkin's lymphoma, thymoma, follicular dendritic cell sarcoma and chronic lymphocytic leukemia are the commonly associated neoplasmas in PNP. "
6.	Doxorubicin (Adriamycin)FDA LinkGeneric 01/01/2008 - "Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin." 12/10/2011 - "Primary follicular dendritic cell sarcoma of liver treated with cyclophosphamide, doxorubicin, vincristine, and prednisone regimen and surgery."
7.	envoplakinIBA 09/01/2005 - "Western blot showed that the medium from both the thymoma and the follicular dendritic cell sarcoma cells recognized 190-kDa periplakin and 210-kDa envoplakin bands of human epithelial proteins as well as recombinant linker regions of periplakin, envoplakin, desmoplakin and bullous pemphigoid antigen 1. ELISA was positive for antidesmoglein 3 antibody. " 08/01/2007 - "PNP patient sera recognize multiple antigens, which have been identified as the plakin protein family that includes desmoplakin, bullous pemphigoid antigen I (BPAG1), envoplakin and periplakin, and desmogleins 1 and 3. Castleman's tumor, non-Hodgkin's lymphoma, thymoma, follicular dendritic cell sarcoma and chronic lymphocytic leukemia are the commonly associated neoplasmas in PNP. "
8.	rituximab (Mabthera)FDA Link 06/01/2008 - "Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma without Castleman's disease; treatment with rituximab." 11/01/2014 - "Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy."
9.	SynucleinsIBA 12/01/2011 - "γ-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors."
10.	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/01/2014 - "Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2015 - "Intraperitoneal follicular dendritic cell sarcoma: role of chemotherapy and bone marrow allotransplantation in locally advanced disease?" 01/01/2014 - "This study indicated that postoperative adjuvant radiotherapy and chemotherapy could extend the survival of a patient with retroperitoneal follicular dendritic cell sarcoma." 01/01/2010 - "We present here a case of a 69-year-old male diagnosed to have follicular dendritic cell sarcoma of the neck which had a rapid and fatal course inspite of chemotherapy and radiotherapy. " 07/01/2013 - "Current treatment of head and neck follicular dendritic cell sarcoma consists of wide radical resection, with associated radiotherapy or chemotherapy only for cases with aggressive disease such as extracapsular invasion, tumor size ≥6 cm or after failure of the first-line surgical treatment."
2.	Adjuvant Radiotherapy 01/01/2014 - "This study indicated that postoperative adjuvant radiotherapy and chemotherapy could extend the survival of a patient with retroperitoneal follicular dendritic cell sarcoma."
3.	Radiotherapy 11/01/2015 - "Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach." 01/01/2010 - "We present here a case of a 69-year-old male diagnosed to have follicular dendritic cell sarcoma of the neck which had a rapid and fatal course inspite of chemotherapy and radiotherapy. " 07/01/2013 - "Current treatment of head and neck follicular dendritic cell sarcoma consists of wide radical resection, with associated radiotherapy or chemotherapy only for cases with aggressive disease such as extracapsular invasion, tumor size ≥6 cm or after failure of the first-line surgical treatment."
4.	Tonsillectomy 12/01/2006 - "The patient underwent diagnostic tonsillectomy for a left tonsillar mass, and follicular dendritic cell sarcoma was diagnosed based on histopathological and immunoperoxidase findings. "
5.	Pneumonectomy (Lung Volume Reduction) 04/01/2014 - "We report a case of a follicular dendritic cell sarcoma arising in Castleman's disease in a 63-year-old man who presented with a large posterior mediastinal mass, which required a radical pneumonectomy for complete resection. " 04/01/2014 - "Right pneumonectomy for resection of a posterior mediastinal follicular dendritic cell sarcoma arising from Castleman's disease."