Calcium-Calmodulin-Dependent Protein Kinase Type 4

A monomeric calcium-calmodulin-dependent protein kinase subtype that is primarily expressed in neuronal tissues; T-LYMPHOCYTES and TESTIS. The activity of this enzyme is regulated by its phosphorylation by CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE.

Also Known As:

CaM Kinase IV; Calcium-Calmodulin-Dependent Protein Kinase IV; Camk-4; Neuronal CaM Kinase Gr; Calcium Calmodulin Dependent Protein Kinase IV; Calcium Calmodulin Dependent Protein Kinase Type 4; Calmodulin Dependent Protein Kinase IV; Calmodulin-Dependent Protein Kinase IV

Networked: 52 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Delivoria-Papadopoulos, Maria: 11 articles (01/2018 - 04/2002)
2.	Ashraf, Qazi M: 8 articles (08/2011 - 04/2002)
3.	Mishra, Om P: 7 articles (08/2008 - 04/2002)
4.	Tsokos, George C: 5 articles (07/2022 - 10/2012)
5.	Koga, Tomohiro: 4 articles (07/2022 - 10/2012)
6.	Ahmad, Faizan: 4 articles (05/2019 - 01/2017)
7.	Hassan, Md Imtaiyaz: 4 articles (05/2019 - 01/2017)
8.	Islam, Asimul: 4 articles (05/2019 - 01/2017)
9.	Zubrow, Alan B: 4 articles (12/2006 - 12/2002)
10.	Fritz, Karen I: 4 articles (01/2006 - 12/2002)

Related Diseases

1.	Hypothermia 01/01/2014 - "In conclusion, our preliminary data show that concurrent administration of Src kinase inhibitor in combination with induction of whole body hypothermia results in augmented neuroprotection as indicated by further attenuation of hypoxic-ischemic induced CaM kinase IV activation and improvement in neuronal membrane integrity compared to hypothermia alone. " 01/01/2018 - "The combination of short-duration hypothermia with Src kinase inhibition following hypoxia further attenuates the increased activation of CaM kinase IV compared to hypothermia alone in the newborn swine brain." 01/01/2018 - "The CaM kinase IV activity in cerebral tissue (pmol Pi/mg protein/min; mean ± SD) was 2,002 ± 729 in normoxia-normothermia, 1,704 ± 18 in normoxia-hypothermia, 6,017 ± 2,510 in hypoxia-normothermia, 4,104 ± 542 in hypoxia-hypothermia (p < 0.05 vs. normoxia-hypothermia), and 2,165 ± 415 in hypoxia-hypothermia with PP2 (p < 0.05 vs. hypoxia-hypothermia). " 01/01/2018 - "Inhibition of Src kinase concurrently with hypothermia further attenuates the hypoxia-induced increased activation of CaM kinase IV compared with hypothermia alone. " 01/01/2014 - "To this aim we assessed the levels of CaM Kinase IV activity as well as the levels of Na+-K+-ATPase in the Cerebral Cortex of Newborn Piglets exposed experimental hypoxia that were treated with hypothermia with or without concomitant PP2 administration. "
2.	Hypoxia (Hypoxemia) 03/17/2011 - "Brain tissue energy dependence of CaM kinase IV cascade activation during hypoxia in the cerebral cortex of newborn piglets." 08/08/2008 - "Mechanism of Ca2+-influx and Ca2+/calmodulin-dependent protein kinase IV activity during in utero hypoxia in cerebral cortical neuronal nuclei of the guinea pig fetus at term." 12/01/2006 - "However, hypoxia-induced increase in CaM Kinase IV activity decreased during the post-Hx reox. " 09/30/2005 - "Previously we have demonstrated that in utero hypoxia results in increased nuclear Ca(2+)-influx and increased CaM kinase IV activity in neuronal nuclei of the guinea pig fetus. " 12/19/2002 - "The results demonstrate that the cerebral tissue hypoxia results in an increase in neuronal nuclear CaM kinase IV activity, and the hypoxia-induced increase in CaM kinase IV activity is NO-mediated."
3.	Inflammation (Inflammations) 02/01/2018 - "The objective of this study is to investigate the role of Calmodulin-dependent protein kinase IV (CaMKIV) in Cardiotoxin (CTX)-induced mice muscle inflammation. " 01/01/2022 - "Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice." 11/01/2019 - "The Ca2+ /calmodulin-dependent protein kinase II (CaMII), Ca2+ /calmodulin-dependent protein kinase IV (CaMKIV), and nuclear factor of activated T cells (NFAT) pathways are likely to be simultaneously activated in muscle cells and in infiltrating lymphocytes and to regulate the immune behaviours of myofibres in an inflammatory environment, and these pathways ultimately affect the outcome of muscle inflammation. " 06/01/2023 - "Ca2+/calmodulin-dependent protein kinase IV attenuates inflammation and mitochondrial dysfunction under insulin resistance in C2C12 cells." 01/01/2019 - "MiR-125a-5p Alleviates Dysfunction and Inflammation of Pentylenetetrazol- induced Epilepsy Through Targeting Calmodulin-dependent Protein Kinase IV (CAMK4)."
4.	Memory Disorders (Memory Loss) 10/01/2008 - "Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging." 10/01/2008 - "Previous studies have suggested that calcium/calmodulin-dependent protein kinase IV (CaMKIV) functions as a positive regulator for memory formation and that age-related memory deficits are the result of dysfunctional signaling pathways mediated by cAMP response element-binding protein (CREB), the downstream transcription factor of CaMKIV. "
5.	Hepatocellular Carcinoma (Hepatoma) 11/01/2000 - "In the current study, the authors demonstrated the expression of CaM-kinase IV in hepatocytes from hepatocellular carcinoma (HCC) in both humans and rats. "

Related Drugs and Biologics

1.	src-Family Kinases
2.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
3.	Calmodulin (Calcium-Dependent Activator Protein)
4.	Tyrosine (L-Tyrosine)
5.	Magnesium Sulfate (Sulfate, Magnesium)
6.	Phosphotransferases (Kinase)
7.	Transcription Factors (Transcription Factor)
8.	Calcium-Calmodulin-Dependent Protein Kinases
9.	Phosphocreatine (Neoton)
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Analgesia