Cardiotoxins

Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.

Also Known As:

Networked: 230 relevant articles (12 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lin, Shinne-Ren: 11 articles (01/2013 - 04/2005)
2.	Chang, Long-Sen: 9 articles (12/2021 - 06/2007)
3.	Chien, Ching-Ming: 7 articles (01/2012 - 04/2005)
4.	Yang, Sheng-Huei: 4 articles (06/2007 - 04/2005)
5.	Chen, Cao-Xin: 3 articles (01/2015 - 01/2014)
6.	Kou, Jian-Qun: 3 articles (01/2015 - 01/2014)
7.	Qin, Zheng-Hong: 3 articles (01/2015 - 01/2014)
8.	Wang, Shu-Zhi: 3 articles (01/2015 - 01/2014)
9.	Xu, Yin-Li: 3 articles (01/2015 - 01/2014)
10.	Chiu, Chien-Chih: 3 articles (01/2013 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "The focus on CV risk among individuals being treated with cardiotoxic agents is important because once the cancer is cured, CV disease becomes the number 1 cause of death among cancer survivors. " 10/01/2017 - "Providing information about long-term side effects and prevention of secondary cancer was significantly correlated only with more concern and more follow-up visits (P ≤ 0.001, respectively), without correlation with more specific awareness of exposure to cardiotoxic agents or radiation. " 05/01/2009 - "Patients undergoing treatment for cancer are not routinely screened using echocardiography, unless their chemotherapeutic regimen includes cardiotoxic agents. " 01/01/2019 - "In this review, we present a paradigm for a precision medicine approach to the care of cardiotoxin-exposed cancer patients. " 03/01/2011 - "There was no increase in the risk of AF frequency in cancer patients who were treated with intravenous ZA, although most of the patients had additional risk factors including previous treatment with cardiotoxic agents or with chest radiotherapy. "
2.	Ischemia 06/10/2022 - "Not all cardiovascular stress is pathologic (e.g., ischemia, pressure overload, cardiotoxins), despite a wealth of studies to this effect. " 01/01/2020 - "In this study, we demonstrate that myeloid cell-derived TGF-β1 signaling is increased in a profibrotic ischemia reperfusion and cardiotoxin muscle injury model. " 06/01/2017 - "We then used cardiotoxin (Ctx) or ischemia-reperfusion (I/R) to induce muscle injury and regeneration and observed increases in Atgs between days 2 and 7 in adult skeletal muscle followed by increased autophagy flux after day 7 Since Ulk1 has been shown to be essential for mitophagy, we asked if Ulk1 is critical for functional regeneration in skeletal muscle. " 01/01/2017 - "Genetically ischemia protected (C57BL/6) and susceptible (BALB/c) mice underwent either unilateral subacute hind limb ischemia (SLI) or myotoxic injury (cardiotoxin) for 28 days. " 01/01/2011 - "ischemia, pressure overload, genetic mutation, cardiotoxin). "
3.	Cardiotoxicity 08/01/2009 - "This justifies further studies in patients where cumulative cardiotoxicity is a concern, as does study of its use with other potentially cardiotoxic agents." 01/01/2021 - "To prevent cardiotoxicity while digging the unique value of AC in cardiac pharmacology, there exists a huge urge to better know the characteristic of AC being a cardiotoxic agent or a potential heart drug. " 01/01/2011 - "Onco-cardiology is an evolving discipline that requires the consideration of cardiotoxicity in preclinical, clinical,and therapeutic aspects of protocol development,treatment, and surveillance of patients who have undergone interventions using cardiotoxic agents. " 02/01/2010 - "the unwanted target causing heart damage) and the development of guidelines to monitor patients undergoing treatment with cardiotoxic agents appear to constitute the basis for the management of drug-induced cardiotoxicity." 01/01/1982 - "This data is interpreted in the light of the homologous group of cardiotoxins possessing two different properties (1) cardiotoxicity and (2) lytic activity; some molecules in the group possess both properties and other possess only one or the other. "
4.	Breast Neoplasms (Breast Cancer) 01/02/2012 - "Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells." 08/01/2021 - "While anthracyclines (ACs) are a class of chemotherapeutic agents that have improved the prognosis of many women with breast cancer, it is one of the most cardiotoxic agents used to treat cancer. " 05/01/2007 - "Importantly, recent advances have also seen the increasing use of another cardiotoxic agent, the monoclonal antibody trastuzumab, both in the metastatic as well as in the adjuvant breast cancer setting. " 08/01/2012 - "This study identified all women at a Midwestern health system with initial diagnosis of American Joint Commission on Cancer Stage III/IV breast cancer (1995-2003) and random sample of 50 women initially diagnosed with Stage I/II who progressed to Stage III/IV. The rate of new cardiovascular outcomes (heart failure, dysrhythmia, and ischemia events) for cardiotoxic (anthracycline or trastuzumab) and non-cardiotoxic agents was calculated. "
5.	Fibrosis (Cirrhosis) 10/28/2020 - "We found a persistent deficiency in skeletal muscle regeneration in Parkin-/- mice after cardiotoxin (CTX) injury with increased area of fibrosis and decreased cross-sectional area (CSA) of myofibres post-injury. " 01/01/2018 - "Here, we injected cardiotoxin into gastrocnemius muscle of Hmox1+/+ and Hmox1-/- animals and analyzed cellular response after muscle injury, focusing on muscle satellite cells (SCs), inflammatory reaction, fibrosis, and formation of new blood vessels. " 01/01/2018 - "N1-scKO and N2-scKO mice both exhibited a defect in muscle regeneration induced by cardiotoxin injection, while muscle regeneration was severely compromised with marked fibrosis in scDKO mice. " 01/01/2016 - "However, these mice exhibited impaired muscle regeneration and increased fibrosis in response to cardiotoxin-induced muscle injury, suggesting that Trbp is required for muscle repair. " 02/11/2022 - "We find that muscle that has recovered from a DUX4 burst acquires a propensity for severe fibrosis, which can be revealed by subsequent cardiotoxin injuries. "

Related Drugs and Biologics

1.	Anthracyclines
2.	Peptides (Polypeptides)
3.	Proteins (Proteins, Gene)
4.	Glycerol (Glycerine)
5.	Venoms
6.	Indicators and Reagents (Reagents)
7.	Elapid Venoms (Cobra Venom)
8.	Amino Acids
9.	Acids
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1.	Injections
2.	Denervation
3.	Transplantation
4.	Drug Therapy (Chemotherapy)
5.	Therapeutics